In vitro, Purkinje cell behaviour is sometimes studied in a dissociated soma preparation in which the dendritic projection has been cleaved. A fraction of these dissociated somas spontaneously burst. The mechanism of this bursting is incompletely understood. We have constructed a biophysical Purkinje soma model, guided and constrained by experimental reports in the literature, that can replicate the somatically driven bursting pattern and which hypothesises Persistent Na(+) current (INaP) to be its burst initiator and SK K(+) current (ISK) to be its burst terminator.
Europe PubMed Central (http://europepmc.org/articles/PMC3742666)
PLoS ONE (https://doaj.org/toc/1932-6203)
Warwick Research Archives Portal Repository (http://wrap.warwick.ac.uk/56147/1/WRAP_Forrest_journal.pone.0068765.pdf)