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Molecular response to interferon beta treatment in multiple sclerosis

Title
Molecular response to interferon beta treatment in multiple sclerosis
Funding
ARC | Linkage Projects
Contract (GA) number
LP0668335
Start Date
2006/01/01
End Date
2008/12/31
Open Access mandate
no
Organizations
-
More information
http://purl.org/au-research/grants/arc/LP0668335

 

  • Novel Approaches to Detect Serum Biomarkers for Clinical Response to Interferon-β Treatment in Multiple Sclerosis

    Gandhi, Kaushal S.; McKay, Fiona C.; Diefenbach, Eve; Crossett, Ben; Schibeci, Stephen D.; Heard, Robert N.; Stewart, Graeme J.; Booth, David R.; Arthur, Jonathan W. (2010)
    Projects: ARC | Molecular response to interferon beta treatment in multiple sclerosis (LP0668335)
    Interferon beta (IFNbeta) is the most common immunomodulatory treatment for relapsing-remitting multiple sclerosis (RRMS). However, some patients fail to respond to treatment. In this study, we identified putative clinical response markers in the serum and plasma of people with multiple sclerosis (MS) treated with IFNbeta. In a discovery-driven approach, we use 2D-difference gel electrophoresis (DIGE) to identify putative clinical response markers and apply power calculations to identify the ...
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