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Discovery Projects - Grant ID: DP140100176
- Title
- Discovery Projects - Grant ID: DP140100176
- Funding
- ARC | Discovery Projects
- Contract (GA) number
- DP140100176
- Start Date
- 2014/01/01
- End Date
- 2016/12/31
- Open Access mandate
- no
- Organizations
- -
- More information
- http://purl.org/au-research/grants/arc/DP140100176
-
Nickel biopathways in tropical nickel hyperaccumulating trees from Sabah (Malaysia)
van der Ent , Antony; Callahan , Damien L.; Noller , Barry N.; Mesjasz-Przybylowicz , Jolanta; Przybylowicz , Wojciech J.; Barnabas , Alban; Harris , Hugh H. (2017)
Projects: ARC | Discovery Projects - Grant ID: DP140100176 (DP140100176), ARC | Discovery Early Career Researcher Award - Grant ID: DE160100429 (DE160100429)The extraordinary level of accumulation of nickel (Ni) in hyperaccumulator plants is a consequence of specific metal sequestering and transport mechanisms, and knowledge of these processes is critical for advancing an understanding of transition element metabolic regulation in these plants. The Ni biopathways were elucidated in three plant species,[br/] Phyllanthus balgooyi, Phyllanthus securinegioides (Phyllanthaceae) and Rinorea bengalensis (Violaceae), that occur in Sabah (Malaysia) on ...A Molecular Probe for the Detection of Polar Lipids in Live Cells
Bader, Christie A.; Shandala, Tetyana; Carter, Elizabeth A.; Ivask, Angela; Guinan, Taryn; Hickey, Shane M.; Werrett, Melissa V.; Wright, Phillip J.; Simpson, Peter V.; Stagni, Stefano; Voelcker, Nicolas H.; Lay, Peter A.; Massi, Massimiliano; Plush, Sally E.; Brooks, Douglas A. (2016)
Projects: NHMRC | Development of effective biomarkers for the diagnosis and prognosis of Prostate Cancer (1092904), ARC | Discovery Projects - Grant ID: DP140100176 (DP140100176), ARC | Discovery Projects - Grant ID: DP130103566 (DP130103566), ARC | Vibrational Spectroscopy Microprobe/FESEM/AFM Imaging of Cells, Tissues and Materials (LE0560680)Lipids have an important role in many aspects of cell biology, including membrane architecture/compartment formation, intracellular traffic, signalling, hormone regulation, inflammation, energy storage and metabolism. Lipid biology is therefore integrally involved in major human diseases, including metabolic disorders, neurodegenerative diseases, obesity, heart disease, immune disorders and cancers, which commonly display altered lipid transport and metabolism. However, the investigation of t...Uncovering system-specific stress signatures in primate teeth with multimodal imaging
Austin, Christine; Smith, Tanya M.; Farahani, Ramin M. Z.; Hinde, Katie; Carter, Elizabeth A.; Lee, Joonsup; Lay, Peter A.; Kennedy, Brendan J.; Sarrafpour, Babak; Wright, Rosalind J.; Wright, Robert O.; Arora, Manish (2016)
Projects: NSF | Longitudinal Investigation of Maternal Influences on Infant Outcomes Mediated by Physiological Investment and Behavioral Care during Lactation in Rhesus Macaques (Macaca mulatta) (0921978), NIH | Early Life Environmental Toxicant Exposure and Oral Health (4R00ES019597-03), ARC | Discovery Projects - Grant ID: DP140100176 (DP140100176), ARC | Vibrational Spectroscopy Microprobe/FESEM/AFM Imaging of Cells, Tissues and Materials (LE0560680), NIH | EFFECTS OF HUMAN GROWTH HORMONE ON ANTIBODY RESPONSES (2P51RR000169-24), NHMRC | Identifying critical windows of susceptibility to metal toxicants using a novel biomarker of intrauterine exposure (1028372), NIH | California National Primate Research Center (8P51OD011107-51), NIH | Reconstructing fetal toxicant exposure and homeostatic disruptions (1DP2ES025453-01)Early life stress can disrupt development and negatively impact long-term health trajectories. Reconstructing histories of early life exposure to external stressors is hampered by the absence of retrospective time-specific biomarkers. Defects in tooth enamel have been used to reconstruct stress but the methods used are subjective and do not identify the specific biological systems impacted by external stressors. Here we show that external physical and social stressors impart biochemical signa... -
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