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Discovery Projects - Grant ID: DP160102766

Title
Discovery Projects - Grant ID: DP160102766
Funding
ARC | Discovery Projects
Contract (GA) number
DP160102766
Start Date
2016/01/01
End Date
2020/12/31
Open Access mandate
no
Organizations
-
More information
http://purl.org/au-research/grants/arc/DP160102766

 

  • Structure aided design of a Neu5Gc specific lectin

    Christopher J. Day; Adrienne W. Paton; Melanie A. Higgins; Lucy K. Shewell; Freda E.-C. Jen; Benjamin L. Schulz; Brock P. Herdman; James C. Paton; Michael P. Jennings (2017)
    Projects: ARC | Discovery Projects - Grant ID: DP160102766 (DP160102766), NHMRC | Protein glycan interactions in infectious diseases. (1071659), NHMRC | How Sweet It Is: diagnostic clinical and experimental glycoproteomics (1087975)
    Subtilase cytotoxin (SubAB) of Escherichia coli is an AB5 class bacterial toxin. The pentameric B subunit (SubB) binds the cellular carbohydrate receptor, α2–3-linked N-glycolylneuraminic acid (Neu5Gc). Neu5Gc is not expressed on normal human cells, but is expressed by cancer cells. Elevated Neu5Gc has been observed in breast, ovarian, prostate, colon and lung cancer. The presence of Neu5Gc is prognostically important, and correlates with invasiveness, metastasis and tumour grade. Neu5Gc bind...
  • No project research data found
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