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ARC Centres of Excellences - Grant ID: CE140100036

Title
ARC Centres of Excellences - Grant ID: CE140100036
Funding
ARC | ARC Centres of Excellences
Contract (GA) number
CE140100036
Start Date
2014/01/01
End Date
2020/12/31
Open Access mandate
no
Organizations
-
More information
http://purl.org/au-research/grants/arc/CE140100036

 

  • A hydrogel based localized release of colistin for antimicrobial treatment of burn wound infection

    Zhu, Chongyu; Jinxin, Zhao; Kempe, Kristian; Wilson, Paul; Wang, Jiping; Velkov, Tony; Li, Jian; Davis, Thomas P.; Whittaker, Michael R.; Haddleton, David M. (2016)
    Projects: ARC | ARC Centres of Excellences - Grant ID: CE140100036 (CE140100036)
    There is an urgent unmet medical need for new treatments for wound and burn infections caused by multidrug-resistant (MDR) Gram-negative ‘superbugs’, especially the problematic Pseudomonas aeruginosa. In this work we report the incorporation of colistin, a potent lipopeptide into a self-healable hydrogel (via dynamic imine bond formation) following the chemical reaction between the amine groups present in glycol chitosan and an aldehyde modified poly (ethylene glycol) (PEG). The storage modul...

    Spatially transformed fluorescence image data for ERK-MAPK and selected proteins within human epidermis

    Cursons, Joseph; Angel, Catherine E.; Hurley, Daniel G.; Print, Cristin G.; Dunbar, P. Rod; Jacobs, Marc D.; Crampin, Edmund J. (2015)
    Projects: ARC | ARC Centres of Excellences - Grant ID: CE140100036 (CE140100036)
    Background Phosphoprotein signalling pathways have been intensively studied in vitro, yet their role in regulating tissue homeostasis is not fully understood. In the skin, interfollicular keratinocytes differentiate over approximately 2?weeks as they traverse the epidermis. The extracellular signal-regulated kinase (ERK) branch of the mitogen-activated protein kinase (MAPK) pathway has been implicated in this process. Therefore, we examined ERK-MAPK activity within human epidermal keratinocyt...

    The complexities and caveats of lineage tracing in the mammary gland

    Rios, Anne C.; Fu, Nai Yang; Cursons, Joseph; Lindeman, Geoffrey J.; Visvader, Jane E. (2016)
    Projects: ARC | ARC Centres of Excellences - Grant ID: CE140100036 (CE140100036)
    Lineage tracing is increasingly being utilised to probe different cell types that exist within the mammary gland. Whilst this technique is powerful for tracking cells in vivo and dissecting the roles of different cellular subsets in development, homeostasis and oncogenesis, there are important caveats associated with lineage tracing strategies. Here we highlight key parameters of particular relevance for the mammary gland. These include tissue preparation for whole-mount imaging, whereby the ...

    Facile access to thermoresponsive filomicelles with tuneable cores

    Truong, Nghia P.; Quinn, John F.; Anastasaki, Athina; Haddleton, David M.; Whittaker, Michael R.; Davis, Thomas P. (2016)
    Projects: ARC | ARC Centres of Excellences - Grant ID: CE140100036 (CE140100036)
    We report a novel library of filomicelles in water comprising either polystyrene or various polymethacrylate cores prepared via temperature-induced morphological transformation (TIMT). The nanoworms demonstrate reproducibly uniform morphology while exhibiting a broad range of glass transition temperatures, high stability in buffer, and the ability to form smart reversible thermoresponsive gels.\ud

    Virtual Reference Environments: a simple way to make research reproducible

    Hurley, Daniel G.; Budden, David M.; Crampin, Edmund J. (2014)
    Projects: ARC | ARC Centres of Excellences - Grant ID: CE140100036 (CE140100036)
    ‘Reproducible research’ has received increasing attention over the past few years as bioinformatics and computational biology methodologies become more complex. Although reproducible research is progressing in several valuable ways, we suggest that recent increases in internet bandwidth and disk space, along with the availability of open-source and free-software licences for tools, enable another simple step to make research reproducible. In this article, we urge the creation of minimal virtu...

    Regulation of ERK-MAPK signaling in human epidermis

    Cursons, Joseph; Gao, Jerry; Hurley, Daniel G.; Print, Cristin G.; Dunbar, P. Rod; Jacobs, Marc D.; Crampin, Edmund J. (2015)
    Projects: ARC | ARC Centres of Excellences - Grant ID: CE140100036 (CE140100036)
    Background The skin is largely comprised of keratinocytes within the interfollicular epidermis. Over approximately two weeks these cells differentiate and traverse the thickness of the skin. The stage of differentiation is therefore reflected in the positions of cells within the tissue, providing a convenient axis along which to study the signaling events that occur in situ during keratinocyte terminal differentiation, over this extended two-week timescale. The canonical ERK-MAPK signaling ca...

    Predicting expression: the complementary power of histone modification and transcription factor binding data

    Budden, David M; Hurley, Daniel G; Cursons, Joseph; Markham, John F; Davis, Melissa J; Crampin, Edmund J (2014)
    Projects: ARC | ARC Centres of Excellences - Grant ID: CE140100036 (CE140100036)
    Background Transcription factors (TFs) and histone modifications (HMs) play critical roles in gene expression by regulating mRNA transcription. Modelling frameworks have been developed to integrate high-throughput omics data, with the aim of elucidating the regulatory logic that results from the interactions of DNA, TFs and HMs. These models have yielded an unexpected and poorly understood result: that TFs and HMs are statistically redundant in explaining mRNA transcript abundance at a genome...

    The Power of Heterogeneity: Parameter Relationships from Distributions.

    Magnus Röding; Siobhan J Bradley; Nathan H Williamson; Melissa R Dewi; Thomas Nann; Magnus Nydén
    Projects: ARC | ARC Centres of Excellences - Grant ID: CE140100036 (CE140100036)
    Complex scientific data is becoming the norm, many disciplines are growing immensely data-rich, and higher-dimensional measurements are performed to resolve complex relationships between parameters. Inherently multi-dimensional measurements can directly provide information on both the distributions of individual parameters and the relationships between them, such as in nuclear magnetic resonance and optical spectroscopy. However, when data originates from different measurements and comes in d...

    Well-defined PDMAEA stars via Cu(0)-mediated reversible deactivation radical polymerization

    Whitfield, Richard; Anastasaki, Athina; Truong, Nghia P.; Wilson, Paul; Kempe, Kristian; Burns, James A.; Davis, Thomas P.; Haddleton, David M. (2016)
    Projects: ARC | ARC Centres of Excellences - Grant ID: CE140100036 (CE140100036)
    The Cu(0)-mediated reversible deactivation radical polymerisation of N,N’-dimethylaminoethyl acrylate in DMSO and IPA at ambient temperature using Cu(0) wire is investigated. Tetra-functional and octa-functional initiators were utilised to facilitate the synthesis of well-defined PDMAEA star homo and block copolymers with a range of molecular weights (Mn ~ 5000-41000 g mol-1). Both solvents demonstrated to be excellent media for the controlled polymerisation of DMAEA yielding narrow molecular...

    Therapeutic Potential of Inorganic Nanoparticles for the Delivery of Monoclonal Antibodies

    Turner, Christopher T.; McInnes, Steven J. P.; Voelcker, Nicolas H.; Cowin, Allison J. (2015)
    Projects: ARC | ARC Centres of Excellences - Grant ID: CE140100036 (CE140100036)
    Monoclonal antibodies (mAbs), available for a range of diseases, including tumours, leukemia, and multiple sclerosis, are emerging as the fastest growing area of therapeutic drug development. The greatest advantage of therapeutic mAbs is their ability to bind with a high degree of specificity to target proteins involved in disease pathophysiology. In response, effector functions are triggered and these ameliorate the disease cascade. As an alternative to this reliance on effector functions, d...
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