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ARC Centres of Excellences - Grant ID: CE140100036

ARC Centres of Excellences - Grant ID: CE140100036
ARC | ARC Centres of Excellences
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  • Therapeutic targeting of polo-like kinase 1 using RNA-interfering nanoparticles (iNOPs) for the treatment of non-small cell lung cancer

    McCarroll, Joshua A.; Dwarte, Tanya; Baigude, Huricha; Dang, Jason; Yang, Lu; Erlich, Rafael B.; Kimpton, Kathleen; Teo, Joann; Sagnella, Sharon M.; Akerfeldt, Mia C.; Liu, Jie; Phillips, Phoebe A.; Rana, Tariq M.; Kavallaris, Maria (2015)
    Projects: ARC | ARC Centres of Excellences - Grant ID: CE140100036 (CE140100036)
    Non-small cell lung cancer (NSCLC) remains the most common cause of cancer death worldwide due its resistance to chemotherapy and aggressive tumor growth. Polo-like kinase 1 (PLK1) is a serine-threonine protein kinase which is overexpressed in cancer cells, and plays a major role in regulating tumor growth. A number of PLK1 inhibitors are in clinical trial; however, poor tumor bioavailability and off-target effects limit their efficacy. Short-interfering-RNA (siRNA) holds promise as a class o...

    Predicting expression: the complementary power of histone modification and transcription factor binding data

    Budden, David M; Hurley, Daniel G; Cursons, Joseph; Markham, John F; Davis, Melissa J; Crampin, Edmund J (2014)
    Projects: ARC | ARC Centres of Excellences - Grant ID: CE140100036 (CE140100036)
    Background Transcription factors (TFs) and histone modifications (HMs) play critical roles in gene expression by regulating mRNA transcription. Modelling frameworks have been developed to integrate high-throughput omics data, with the aim of elucidating the regulatory logic that results from the interactions of DNA, TFs and HMs. These models have yielded an unexpected and poorly understood result: that TFs and HMs are statistically redundant in explaining mRNA transcript abundance at a genome...

    Regulation of ERK-MAPK signaling in human epidermis

    Cursons, Joseph; Gao, Jerry; Hurley, Daniel G.; Print, Cristin G.; Dunbar, P. Rod; Jacobs, Marc D.; Crampin, Edmund J. (2015)
    Projects: ARC | ARC Centres of Excellences - Grant ID: CE140100036 (CE140100036)
    Background The skin is largely comprised of keratinocytes within the interfollicular epidermis. Over approximately two weeks these cells differentiate and traverse the thickness of the skin. The stage of differentiation is therefore reflected in the positions of cells within the tissue, providing a convenient axis along which to study the signaling events that occur in situ during keratinocyte terminal differentiation, over this extended two-week timescale. The canonical ERK-MAPK signaling ca...

    The Power of Heterogeneity: Parameter Relationships from Distributions

    Röding, M.; Bradley, S. J.; Williamson, N. H.; Dewi, M. R.; Nann, T.; Nydén, M. (2016)
    Projects: ARC | ARC Centres of Excellences - Grant ID: CE140100036 (CE140100036)
    Complex scientific data is becoming the norm, many disciplines are growing immensely data-rich, and higher-dimensional measurements are performed to resolve complex relationships between parameters. Inherently multi-dimensional measurements can directly provide information on both the distributions of individual parameters and the relationships between them, such as in nuclear magnetic resonance and optical spectroscopy. However, when data originates from different measurements and comes in d...

    The complexities and caveats of lineage tracing in the mammary gland

    Rios, Anne C.; Fu, Nai Yang; Cursons, Joseph; Lindeman, Geoffrey J.; Visvader, Jane E. (2016)
    Projects: ARC | ARC Centres of Excellences - Grant ID: CE140100036 (CE140100036)
    Lineage tracing is increasingly being utilised to probe different cell types that exist within the mammary gland. Whilst this technique is powerful for tracking cells in vivo and dissecting the roles of different cellular subsets in development, homeostasis and oncogenesis, there are important caveats associated with lineage tracing strategies. Here we highlight key parameters of particular relevance for the mammary gland. These include tissue preparation for whole-mount imaging, whereby the ...

    Nitric oxide-releasing porous silicon nanoparticles

    Kafshgari, Morteza; Cavallaro, Alex; Delalat, Bahman; Harding, Frances J; McInnes, Steven JP; Mäkilä, Ermei; Salonen, Jarno; Vasilev, Krasimir; Voelcker, Nicolas H (2014)
    Projects: ARC | ARC Centres of Excellences - Grant ID: CE140100036 (CE140100036)
    In this study, the ability of porous silicon nanoparticles (PSi NPs) to entrap and deliver nitric oxide (NO) as an effective antibacterial agent is tested against different Gram-positive and Gram-negative bacteria. NO was entrapped inside PSi NPs functionalized by means of the thermal hydrocarbonization (THC) process. Subsequent reduction of nitrite in the presence of d-glucose led to the production of large NO payloads without reducing the biocompatibility of the PSi NPs with mammalian cells...

    Allometric scaling of skin thickness, elasticity, viscoelasticity to mass for micro-medical device translation: from mice, rats, rabbits, pigs to humans

    Wei, Jonathan C. J.; Edwards, Grant A.; Martin, Darren J.; Huang, Han; Crichton, Michael L.; Kendall, Mark A. F. (2017)
    Projects: ARC | ARC Centres of Excellences - Grant ID: CE140100036 (CE140100036)
    Emerging micro-scale medical devices are showing promise, whether in delivering drugs or extracting diagnostic biomarkers from skin. In progressing these devices through animal models towards clinical products, understanding the mechanical properties and skin tissue structure with which they interact will be important. Here, through measurement and analytical modelling, we advanced knowledge of these properties for commonly used laboratory animals and humans (~30 g to ~150 kg). We hypothesise...

    Selective assembly of Au-Fe3O4 nanoparticle hetero-dimers

    Dewi, Melissa R.; Laufersky, Geoffry; Nann, Thomas (2015)
    Projects: ARC | ARC Centres of Excellences - Grant ID: CE140100036 (CE140100036)
    Hetero-dimeric magnetic nanoparticles of the type Au-Fe3O4 have been synthesised from separately prepared, differently shaped (spheres and cubes), monodisperse nanoparticles. This synthesis was achieved by the following steps: (a) Mono-functionalising each type of nanoparticles with aldehyde functional groups through a solid support approach, where nanoparticle decorated silica nanoparticles were fabricated as an intermediate step; (b) Derivatising the functional faces with complementary func...

    Modelling the conditional regulatory activity of methylated and bivalent promoters

    Budden, David M.; Hurley, Daniel G.; Crampin, Edmund J. (2015)
    Projects: ARC | ARC Centres of Excellences - Grant ID: CE140100036 (CE140100036)
    Background Predictive modelling of gene expression is a powerful framework for the in silico exploration of transcriptional regulatory interactions through the integration of high-throughput -omics data. A major limitation of previous approaches is their inability to handle conditional interactions that emerge when genes are subject to different regulatory mechanisms. Although chromatin immunoprecipitation-based histone modification data are often used as proxies for chromatin accessibility, ...

    Facile access to thermoresponsive filomicelles with tuneable cores

    Truong, Nghia P.; Quinn, John F.; Anastasaki, Athina; Haddleton, David M.; Whittaker, Michael R.; Davis, Thomas P. (2016)
    Projects: ARC | ARC Centres of Excellences - Grant ID: CE140100036 (CE140100036)
    We report a novel library of filomicelles in water comprising either polystyrene or various polymethacrylate cores prepared via temperature-induced morphological transformation (TIMT). The nanoworms demonstrate reproducibly uniform morphology while exhibiting a broad range of glass transition temperatures, high stability in buffer, and the ability to form smart reversible thermoresponsive gels.\ud
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