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Molecular control of embryonic patterning: The function of Rhou gene in mediating response to WNT signalling

Title
Molecular control of embryonic patterning: The function of Rhou gene in mediating response to WNT signalling
Funding
ARC | Discovery Projects
Contract (GA) number
DP0985052
Start Date
2009/01/01
End Date
2011/12/31
Open Access mandate
no
Organizations
-
More information
http://purl.org/au-research/grants/arc/DP0985052

 

  • Rho GTPases in endoderm development and differentiation

    The embryonic foregut of the mouse embryo is lined by a layer of endoderm cells whose architecture changes during development. The transition from a squamous to columnar epithelial morphology is accompanied by the upregulation of an atypical Rho GTPase, Rhou. Subsequently, multi-layering of the epithelium at the site of organ bud formation is associated with the downregulation of Rhou. Rho-related small GTPases are known to play multiple roles in establishing and maintaining epithelial polari...
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