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fbtwitterlinkedinvimeoflicker grey 14rssslideshare1

Head and face development: dissecting tissue-specific gene function

Title
Head and face development: dissecting tissue-specific gene function
Funding
ARC | Discovery Projects
Contract (GA) number
DP1094008
Start Date
2010/01/01
End Date
2012/12/31
Open Access mandate
no
Organizations
-
More information
http://purl.org/au-research/grants/arc/DP1094008

 

  • Timed Deletion of Twist1 in the Limb Bud Reveals Age-Specific Impacts on Autopod and Zeugopod Patterning

    Loebel, David A. F.; Hor, Angelyn C. C.; Bildsoe, Heidi K.; Tam, Patrick P. L. (2014)
    Projects: ARC | Head and face development: dissecting tissue-specific gene function (DP1094008)
    Twist1 encodes a transcription factor that plays a vital role in limb development. We have used a tamoxifen-inducible Cre transgene, Ubc-CreERT2, to generate time-specific deletions of Twist1 by inducing Cre activity in mouse embryos at different ages from embryonic (E) day 9.5 onwards. A novel forelimb phenotype of supernumerary pre-axial digits and enlargement or partial duplication of the distal radius was observed when Cre activity was induced at E9.5. Gene expression analysis revealed si...
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