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New Methods for Structural Biology in Solution

Title
New Methods for Structural Biology in Solution
Funding
ARC | Discovery Projects
Contract (GA) number
DP0877540
Start Date
2008/01/01
End Date
2010/12/31
Open Access mandate
no
Organizations
-
More information
http://purl.org/au-research/grants/arc/DP0877540

 

  • NMR Analysis of the Dynamic Exchange of the NS2B Cofactor between Open and Closed Conformations of the West Nile Virus NS2B-NS3 Protease

    Su, Xun-Cheng; Ozawa, Kiyoshi; Qi, Ruhu; Vasudevan, Subhash G.; Lim, Siew P.; Otting, Gottfried (2009)
    Projects: ARC | New Methods for Structural Biology in Solution (DP0877540)
    BACKGROUND: The two-component NS2B-NS3 proteases of West Nile and dengue viruses are essential for viral replication and established targets for drug development. In all crystal structures of the proteases to date, the NS2B cofactor is located far from the substrate binding site (open conformation) in the absence of inhibitor and lining the substrate binding site (closed conformation) in the presence of an inhibitor. METHODS: In this work, nuclear magnetic resonance (NMR) spectroscopy of isot...
  • No project research data found
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