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Linkage Projects - Grant ID: LP140100095

Title
Linkage Projects - Grant ID: LP140100095
Funding
ARC | Linkage Projects
Contract (GA) number
LP140100095
Start Date
2014/01/01
End Date
2017/12/31
Open Access mandate
no
Organizations
-
More information
http://purl.org/au-research/grants/arc/LP140100095

 

  • Rubidium and potassium levels are altered in Alzheimer’s disease brain and blood but not in cerebrospinal fluid

    Roberts, Blaine R.; Doecke, James D.; Rembach, Alan; Yévenes, L. Fernanda; Fowler, Christopher J.; McLean, Catriona A.; Lind, Monica; Volitakis, Irene; Masters, Colin L.; Bush, Ashley I.; Hare, Dominic J. (2016)
    Projects: ARC | Linkage Projects - Grant ID: LP140100095 (LP140100095)
    Loss of intracellular compartmentalization of potassium is a biochemical feature of Alzheimer’s disease indicating a loss of membrane integrity and mitochondrial dysfunction. We examined potassium and rubidium (a biological proxy for potassium) in brain tissue, blood fractions and cerebrospinal fluid from Alzheimer’s disease and healthy control subjects to investigate the diagnostic potential of these two metal ions. We found that both potassium and rubidium levels were significantly decrease...

    Trehalose Improves Cognition in the Transgenic Tg2576 Mouse Model of Alzheimer’s Disease

    Portbury, Stuart D.; Hare, Dominic J.; Sgambelloni, Charlotte; Perronnes, Kali; Portbury, Ashley J.; Finkelstein, David I.; Adlard, Paul A. (2017)
    Projects: ARC | Linkage Projects - Grant ID: LP140100095 (LP140100095)
    This study assessed the therapeutic utility of the autophagy enhancing stable disaccharide trehalose in the Tg2576 transgenic mouse model of Alzheimer’s disease (AD) via an oral gavage of a 2% trehalose solution for 31 days. Furthermore, as AD is a neurodegenerative condition in which the transition metals, iron, copper, and zinc, are understood to be intricately involved in the cellular cascades leading to the defining pathologies of the disease, we sought to determine any parallel impact of...

    Trehalose improves traumatic brain injury-induced cognitive impairment

    Traumatic brain Injury (TBI) is a significant cause of death and long-term disability for which there are currently no effective pharmacological treatment options. In this study then, we utilized a mouse model of TBI to assess the therapeutic potential of the stable disaccharide trehalose, which is known to protect against oxidative stress, increase levels of chaperone molecules and enhance autophagy. Furthermore, trehalose has demonstrated neuroprotective properties in numerous animal models...
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