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TAILORING OF LAYERED DOUBLE HYDROXIDE NANOPARTICLES FOR EFFECTIVE DELIVERY OF BIOLOGICALLY ACTIVE PEPTIDES AND cDNAs

Title
TAILORING OF LAYERED DOUBLE HYDROXIDE NANOPARTICLES FOR EFFECTIVE DELIVERY OF BIOLOGICALLY ACTIVE PEPTIDES AND cDNAs
Funding
ARC | Discovery Projects
Contract (GA) number
DP0559594
Start Date
2005/01/01
End Date
2007/12/31
Open Access mandate
no
Organizations
-
More information
http://purl.org/au-research/grants/arc/DP0559594

 

  • Layered double hydroxide nanoparticles as cellular delivery vectors of supercoiled plasmid DNA

    Xu, Zhi Ping; Walker, Tara L; Liu, Kerh-lin; Cooper, Helen M; Lu, GQ Max; Bartlett, Perry F (2007)
    Projects: ARC | TAILORING OF LAYERED DOUBLE HYDROXIDE NANOPARTICLES FOR EFFECTIVE DELIVERY OF BIOLOGICALLY ACTIVE PEPTIDES AND cDNAs (DP0559594)
    We prepared stable homogeneous suspensions with layered double hydroxide (LDH) nanoparticles for in vitro gene delivery tests. The viability of HEK 293T cells in the presence of LDH nanoparticles at different concentrations was investigated. This revealed 50% cell viability at 500 μg/mL of LDH nanoparticles that is much higher than 50–100 μg/mL used for the delivery tests. The supercoiled pEF-eGFP plasmid (ca. 6100 base pairs) was mixed with LDH nanoparticle suspensions for anion exchange at ...
  • No project research data found
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