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Rhinovirus impairs physiological and immunological lung development and causes exacerbation of allergic airways disease

Title
Rhinovirus impairs physiological and immunological lung development and causes exacerbation of allergic airways disease
Funding
ARC | Discovery Projects
Contract (GA) number
DP110101706
Start Date
2011/01/01
End Date
2013/12/31
Open Access mandate
no
Organizations
-
More information
http://purl.org/au-research/grants/arc/DP110101706

 

  • Rhinovirus Exacerbates House-Dust-Mite Induced Lung Disease in Adult Mice

    Phan, Jennifer A.; Kicic, Anthony; Berry, Luke J.; Fernandes, Lynette B.; Zosky, Graeme R.; Sly, Peter D.; Larcombe, Alexander N. (2014)
    Projects: ARC | Rhinovirus impairs physiological and immunological lung development and causes exacerbation of allergic airways disease (DP110101706)
    Human rhinovirus is a key viral trigger for asthma exacerbations. To date, murine studies investigating rhinovirus-induced exacerbation of allergic airways disease have employed systemic sensitisation/intranasal challenge with ovalbumin. In this study, we combined human-rhinovirus infection with a clinically relevant mouse model of aero-allergen exposure using house-dust-mite in an attempt to more accurately understand the links between human-rhinovirus infection and exacerbations of asthma. ...
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