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Gamete-specific knockout of Fizzy-Related to examine its meiotic role in oocytes and sperm

Title
Gamete-specific knockout of Fizzy-Related to examine its meiotic role in oocytes and sperm
Funding
ARC | Discovery Projects
Contract (GA) number
DP110100418
Start Date
2011/01/01
End Date
2014/12/31
Open Access mandate
no
Organizations
-
More information
http://purl.org/au-research/grants/arc/DP110100418

 

  • Premature dyad separation in meiosis II is the major segregation error with maternal age in mouse oocytes

    As women get older their oocytes become susceptible to chromosome mis-segregation. This generates aneuploid embryos, leading to increased infertility and birth defects. Here we examined the provenance of aneuploidy by tracking chromosomes and their kinetochores in oocytes from young and aged mice. Changes consistent with chromosome cohesion deterioration were found with age, including increased interkinetochore distance and loss of the centromeric protector of cohesion SGO2 in metaphase II ar...
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