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Discovery Projects - Grant ID: DP130102461

Title
Discovery Projects - Grant ID: DP130102461
Funding
ARC | Discovery Projects
Contract (GA) number
DP130102461
Start Date
2013/01/01
End Date
2015/12/31
Open Access mandate
no
Organizations
-
More information
http://purl.org/au-research/grants/arc/DP130102461

 

  • Molecular Structure of Human-Liver Glycogen

    Deng, Bin; Sullivan, Mitchell A.; Chen, Cheng; Li, Jialun; Powell, Prudence O.; Hu, Zhenxia; Gilbert, Robert G. (2016)
    Projects: ARC | Discovery Projects - Grant ID: DP130102461 (DP130102461)
    Glycogen is a highly branched glucose polymer which is involved in maintaining blood-sugar homeostasis. Liver glycogen contains large composite α particles made up of linked β particles. Previous studies have shown that the binding which links β particles into α particles is impaired in diabetic mice. The present study reports the first molecular structural characterization of human-liver glycogen from non-diabetic patients, using transmission electron microscopy for morphology and size-exclu...

    Acid Hydrolysis and Molecular Density of Phytoglycogen and Liver Glycogen Helps Understand the Bonding in Glycogen ? (Composite) Particles

    Powell, Prudence O.; Sullivan, Mitchell A.; Sheehy, Joshua J.; Schulz, Benjamin L.; Warren, Frederick J.; Gilbert, Robert G. (2015)
    Projects: ARC | Discovery Projects - Grant ID: DP130102461 (DP130102461)
    Phytoglycogen (from certain mutant plants) and animal glycogen are highly branched glucose polymers with similarities in structural features and molecular size range. Both appear to form composite α particles from smaller β particles. The molecular size distribution of liver glycogen is bimodal, with distinct α and β components, while that of phytoglycogen is monomodal. This study aims to enhance our understanding of the nature of the link between liver-glycogen β particles resulting in the f...
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