LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1

Novel pharmacological agents to target stroke-induced brain injury

Title
Novel pharmacological agents to target stroke-induced brain injury
Funding
ARC | Future Fellowships
Contract (GA) number
FT100100427
Start Date
2010/01/01
End Date
2014/12/31
Open Access mandate
no
Organizations
-
More information
http://purl.org/au-research/grants/arc/FT100100427

 

  • Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

    Yang-Wei Fann, D; Lee, S-Y; Manzanero, S; Tang, S-C; Gelderblom, M; Chunduri, P; Bernreuther, C; Glatzel, M; Cheng, Y-L; Thundyil, J; Widiapradja, A; Lok, K-Z; Foo, S L; Wang, Y-C; Li, Y-I;... (2013)
    Projects: ARC | Novel pharmacological agents to target stroke-induced brain injury (FT100100427)
    Multi-protein complexes called inflammasomes have recently been identified and shown to contribute to cell death in tissue injury. Intravenous immunoglobulin (IVIg) is an FDA-approved therapeutic modality used for various inflammatory diseases. The objective of this study is to investigate dynamic responses of the NLRP1 and NLRP3 inflammasomes in stroke and to determine whether the NLRP1 and NLRP3 inflammasomes can be targeted with IVIg for therapeutic intervention. Primary cortical neurons w...

    Calorie restriction and stroke

    Manzanero, Silvia; Gelderblom, Mathias; Magnus, Tim; Arumugam, Thiruma V (2011)
    Projects: ARC | Novel pharmacological agents to target stroke-induced brain injury (FT100100427)
    Abstract Stroke, a major cause of disability and mortality in the elderly, occurs when a cerebral blood vessel is occluded or ruptured, resulting in ischemic damage and death of brain cells. The injury mechanism involves metabolic and oxidative stress, excitotoxicity, apoptosis and inflammatory processes, including activation of glial cells and infiltration of leukocytes. In animal models, dietary energy restriction, by daily calorie reduction (CR) or intermittent fasting (IF), extends lifesp...

    Evidence that the EphA2 receptor exacerbates ischemic brain injury.

    John Thundyil; Silvia Manzanero; Dale Pavlovski; Tanya R Cully; Ker-Zhing Lok; Alexander Widiapradja; Prasad Chunduri; Dong-Gyu Jo; Chie Naruse; Masahide Asano; Bradley S Launikonis; Christopher G Sobey; Mark G Coulthard; Thiruma V Arumugam
    Projects: ARC | Novel pharmacological agents to target stroke-induced brain injury (FT100100427)
    Ephrin (Eph) signaling within the central nervous system is known to modulate axon guidance, synaptic plasticity, and to promote long-term potentiation. We investigated the potential involvement of EphA2 receptors in ischemic stroke-induced brain inflammation in a mouse model of focal stroke. Cerebral ischemia was induced in male C57Bl6/J wild-type (WT) and EphA2-deficient (EphA2(-/-)) mice by middle cerebral artery occlusion (MCAO; 60 min), followed by reperfusion (24 or 72 h). Brain infarct...

    Over-expression of DSCR1 protects against post-ischemic neuronal injury.

    Vanessa H Brait; Katherine R Martin; Alicia Corlett; Brad R S Broughton; Hyun Ah Kim; John Thundyil; Grant R Drummond; Thiruma V Arumugam; Melanie A Pritchard; Christopher G Sobey
    Projects: NHMRC | ROLE OF A DOWN SYNDROME-RELATED PROTEIN IN STROKE OUTCOME (606488), ARC | Novel pharmacological agents to target stroke-induced brain injury (FT100100427)
    Background and Purpose The Down syndrome candidate region 1 (DSCR1) gene is located on human chromosome 21 and its protein is over-expressed in brains of Down syndrome individuals. DSCR1 can modulate the activity of calcineurin, a phosphatase abundant in the brain, but its influence on stroke outcome is not clear. We compared stroke outcome in wildtype (WT) and transgenic (DSCR1-TG) mice which over-express isoform 1 of human DSCR1. Methods Transient cerebral ischemia was produced by occlusion...
  • No project research data found
  • Scientific Results

    Chart is loading... It may take a bit of time. Please be patient and don't reload the page.

    PUBLICATIONS BY ACCESS MODE

    Chart is loading... It may take a bit of time. Please be patient and don't reload the page.

    Publications in Repositories

    Chart is loading... It may take a bit of time. Please be patient and don't reload the page.

Share - Bookmark

App Box