LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Publisher: Altai State University
Journal: Khimiia rastitel'nogo syr'ia (Chemistry of plant raw material)
Languages: Russian
Types: Article
Subjects: self-association, glycyrrhetinic acid, glycyrrhizic acid, mass spectrometry with electrospray ionization, supramolecular complexes, самоассоциация; глицирретиновая кислота; глицирризиновая кислота; масс-спектрометрия; ионизация электрораспылением; комплексообразование; супрамолекулярные комплексы
Mass spectrometrywith the electrospray ionizationwas used to studythe processes of self-association of glycyrrhetinicacid, which is the aglycone of glycyrrhizic acid. It was shown that stereoisomers of glycyrrhetinicacidcan form self-associates by analogywithtriterpenesaponinswith the free carboxylgroups.The ability glycyrrhetinic acid to form self-associates was registered in the mass spectra. It has been established that the ionization of associates GLA to form the anion occurs quite weak. At the same time, GLA ionization in the positive ion mode occurs efficiently and allows registering multidimensional structures 1 to 8 molecules of 18α-GLA and 1 to 9 molecules of 18β-GLA. The most comprehensive structure of associates GLA is presented in the mass spectra of positive ions. The resultsdemonstrated the ability of18α- and18β-GLA to formself-associates, and highpotential of GLA to formsupramolecular complexes. Stereoisomers ofglycyrrhetinicaslicoricesaponinsmaybe a basis for thesynthesisof a new generationof non-covalentmolecular complexesandnew highlymedicinal substancesfor both improvementof bioavailability.
  • No references.
  • No related research data.
  • No similar publications.

Share - Bookmark

Cite this article