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Publisher: Altai State University
Journal: Khimiia rastitel'nogo syr'ia (Chemistry of plant raw material)
Languages: Russian
Types: Article
Subjects: Chamaecytisus ruthenicus (Fabaceae); quinolizidine alkaloids; influenza virus A (H1N1)pdm09; index of selectivity, Chamaecytisus ruthenicus (Fabaceae); хинолизидиновые алкалоиды; вирус гриппа А H1N1
Activity of the four fractions of the total alkaloids of Chamaecytisus ruthenicus (Fabaceae) collected at the flowering period in the South Ural region against influenza virus A (H1N1) was investigated. The componentsof the alkaloid mixtures were identified by GC/MS method. Cytotoxicity and antiflu properties of the sum and fractions of alkaloids Ch. ruthenicus have been studied in vitro (MDCK cells and flu virus of a А/California/07/09(H1N1)pdm09); rimantadin was used as a standard drug. CTD50 (50% сytotoxic dose), EC50 (50% effective dose), and also an index of selectivity SI (relation CTD50 to EC50), characterizing the antiviral action have been calculated. According to the obtained data, the sum of alkaloids Ch. Ruthenicus (major alkaloids – sparteine contain, 17-oksospartein, lupanine, 10,17-dioksospartein) and fraction 4 (major alkaloids – sparteine and lupanine) possess the high antuflu activity (SI = 77 and SI=52). It is shown that the calculated indexes of selectivity (SI) for the sum of alkaloids of Ch. Ruthenicus and its fractions considerably surpass those for a standard drug rimantadin (SI = 5). This fact confirms the perspective of the further studying of antiviral properties of individual alkaloids Сh. rithenicus for the purpose of search new antiflu agents among plant substances.
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