LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Publisher: Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования «Алтайский государственный университет»
Journal: Химия растительного сырья
Languages: Russian
Types: Article
Subjects: Chemistry, Q, plant extracts, QD1-999, Science, anti-inflammatory, TNF-α ASSAY, anti-inflammatory; plant extracts; TNF-α assay; PGE2 assay, PGE2 assay

Classified by OpenAIRE into

mesheuropmc: lipids (amino acids, peptides, and proteins)

The effects of the ethanolic extracts of 105 plants used in Russian traditional medicine, 26 vegetables and fruits and 2 mushrooms on the release of tumor necrosis factor α (TNF-α) and prostaglandin E2 (PGE2) in lipopolysaccharide (LPS)-stimulated differentiated human acute monocytic leukemia THP-1 cells were studied using TNF-α and PGE2 assays, respectively. We found that 16 plant extracts inhibited TNF-α production and 15 extracts decreased PGE2 release in the cells in a concentration-dependent manner. Guilder rose, tansy, shrubby cinquefoil, wintergreen and prince's pine, the last two of which belong to the Pyrolaceae family, notably inhibited the levels of both of the inflammatory mediators.

  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 1. Medzhitov R. Nature, 2008, vol. 454, pp. 428-435.
    • 2. Allam R., Anders H.J. Current Opinion in Rheumatology, 2008, vol. 20, pp. 538-544.
    • 3. Uchida K. Molecules and Cells, 2008, vol. 25, pp. 347-351.
    • 4. Lin W.J., Yeh W.C. Shock, 2005, vol. 24, pp. 206-209.
    • 5. Makarov S.S. Molecular Medicine Today, 2000, vol. 6, pp. 441-448.
    • 6. Goldberg R.B. The Journal of Clinical Endocrinology & Metabolism, 2009, vol. 94, pp. 3171-3182.
    • 7. Martel-Pelletier J., Pelletier J.P., Fahmi H. Seminars in Arthritis and Rheumatism, 2003, vol. 33, pp. 155-167.
    • 8. Hla T., Neilson K. Proceedings of the National Academy of Sciences USA, 1992, vol. 89, no. 16, pp. 7384-7388.
    • 9. Yamada M., Niki H., Yamashita M., Mue S., Ohuchi K. The Journal of Pharmacology and Experimental Therapeutics, 1997, vol. 281, pp. 1005-1012.
    • 10. Iwalewa E.O., McGaw L.J., Naidoo V., Eloff J.N. African Journal of Biotechnology, 2007, vol. 6, pp. 2868-2885.
    • 11. Garret A., FitzGerald M.D. The New England Journal of Medicine, 2004, vol. 351, pp. 1709-1711.
    • 12. Chainani-Wu N. The Journal of Alternative and Complementary Medicine, 2003, vol. 9, pp. 161-168.
    • 13. Aggarwal B.B., Shishodia S. Biochemical Pharmacology, 2006, vol. 71, pp. 1397-1421.
    • 14. Kong D.X., Li X.J., Zhang H.Y. Drug Discovery Today, 2008, vol. 14, pp. 115-119.
    • 15. Ivanov S.A., Nomura K., Malfanov I.L., Sklyar I.V., Ptitsyn L.R. Fitoterapia, 2011, vol. 82, pp. 212-218.
    • 16. Tsuchiya S., Yamabe M., Yamaguchi Y., Kobayashi Y., Konno T., Tada K. International Journal of Cancer, 1980, vol. 26, pp. 171-176.
    • 17. Park E.K., Jung H.S., Yang H.I., Yoo M.C., Kim C., Kim K.S. Inflammation Research, 2007, vol. 56, pp. 45-50.
  • No related research data.
  • Discovered through pilot similarity algorithms. Send us your feedback.