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Miller, Margaret Ann (2011)
Publisher: Microbial Ecology in Health and Disease
Journal: Microbial Ecology in Health and Disease
Languages: English
Types: Article

Classified by OpenAIRE into

mesheuropmc: food and beverages
In the US, antimicrobials used in animals for both therapeutic and growth promotion purposes are considered animals drugs. Antimicrobial drugs are used in animals to treat and prevent disease, and to increase production. Before any animal drug can be legally marketed in the US, the drug’s sponsor must have a New Animal Drug Application (NADA) approved by the Food and Drug Administration (FDA). Within FDA, the Center for Veterinary Medicine (CVM) is responsible for determining when an animal drug is effective and safe for the animal, the environment and can be manufactured to uniform standards of purity, strength and identity. When the animal drug is intended for use in food-producing animals, the drug sponsor must also demonstrate that edible products from the treated animals are safe for consumers (1). While CVM is responsible for performing the safety assessment for animal drug residues, the United States Department of Agriculture (USDA), Food Safety Inspection Service is responsible for testing the meat supply for microbiological contamination and animal drug residues. Both FDA and USDA have extensive programs to ensure that meat, milk and other animal products are safe and wholesome.
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    • 1. Friedlander LG, Brynes SD, Ferna┬┤ndez AH. The Human Food Safety Evalution of new Animal Drugs, In: Tollefson L (ed.), The Veterinary Clinics of North America, W.B. Saunders Co., Philadelphia, March 1999: p. 1 - 11.
    • 2. Teske RH. Microbiological Signi cance of Drug Residues in Food: Welcome and Introduction. Veterinary and Human Toxicology 1993; 35 (supplement 1): 1 - 2.
    • 3. Carman RJ, Van Tassell RL, Wilkins TD. The Normal Intestinal Micro ora: Ecology, Variability and Stability. Veterinary and Human Toxicology 1993; 35 (supplement 1): 11- 4.
    • 4. Gorbach SL. Perturbation of Intestinal Flora. Veterinary and Human Toxicology 1993; 35 (supplement 1): 15- 23.
    • 5. FDA-CVM Guideline 18. Antibacterial Drugs in Animal Feeds: Human Health Safety Criteria.
    • 6. Rollins LD, Gaines SA, Pocurull DW, et al. Animal Model for Determining the No-Effect Level of an Antimicrobial Drug on Drug Resistance in the Lactose-Fermenting Enteric Flora. Antimicrobial Agents and Chemotherapy 1973; 7 (5): 661-5.
    • 7. FDA-CVM Guideline 52. Microbiological Testing of Antimicrobial Drug Residues in Food. January, 1996.
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