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Ebbesson, Sven O. E.; Ebbesson, Lars O. E.; Swenson, Michael; Kennish, John M.; Robbins, David C. (2005)
Publisher: Co-Action Publishing
Journal: International Journal of Circumpolar Health
Languages: English
Types: Article
Subjects: blood pressure, cardiovascular disease, cholesterol, Inuit, omega-3 fatty acids, palmitic acid
Objectives. To test the efficacy of a simple intervention method to reduce risk factors for type 2 diabetes (DM) and cardiovascular disease (CVD) in Alaskan Eskimos. Study Design. The study consisted of 1) a comprehensive screening for risk factors of 454 individuals in 4 villages, 2) a 4-year intervention and 3) a repetition of the screening in year 5 to test the efficacy of the intervention. Methods. Personal counseling (1hr/year) stressed the consumption of more traditional foods high in ω-3 fatty acids and less of certain specific store-bought foods high in palmitic acid, which was identified as being associated with glucose intolerance. Results. The intervention resulted in significant reductions in plasma concentrations of total cholesterol (p = 0.0001), LDL cholesterol (p = 0.0001), fasting glucose (p = 0.0001), diastolic blood pressure (p = 0.0007) and improved glucose tolerance (p = 0.0006). This occurred without loss of body weight. Sixty percent of the participants had improved glucose tolerance; only one of the 44 originally identified with impaired glucose tolerance (IGT) developed DM during the study. Conclusions. Dramatic improvements of risk factors for DM and CVD were achieved in the intervention by primarily stressing the need for changes in the consumption of specific fats. The results suggest that fat consumption is an important risk factor for DM.(Int J Circumpolar Health 2005; 64(4):409-424)Keywords: blood pressure, cardiovascular disease, cholesterol, Inuit, omega-3 fatty acids, palmitic acid
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    • 1. Scott EM, Griffith I V: Diabetes mellitus in Eskimos. Metabolism 1957; 6:320-325.
    • 2. Ebbesson SOE, Schraer CD, Risica PM, et al. Diabetes mellitus and impaired glucose tolerance in three Alaskan Eskimo populations: The Alaska-Siberia Project. Diabetes Care 1998; 21:563-569.
    • 3. Schraer CD, Ebbesson SOE, Adler A, Cohen JS, Boyko EJ, Nobmann ED. Glucose tolerance and insulin-resistance syndrome among St. Lawrence Island Eskimos: The Alaska-Siberia Project. Proc. X International Congress on Circumpolar Health, 1997; 348- 354.
    • 4. Davidson M, Bulkow LR, Gellin BG. Cardiac mortality in Alaska's indigenous and non-native residents. Int J Epidemiology 1993; 22:62-71.
    • 5. Lanier AP, Ehrsam G, Sandidge J. Alaska Native Mortality 1989-1998. Office of Alaska Native Health Research, Division of Community Health Services, Alaska Native Tribal Health Consortium, July, 2002.
    • 6. Bjerregaard P, Young TK, Hegele RA. Low incidence of cardiovascular disease among the Inuit-what is the evidence? Atherosclerosis 2003; 166: 351-357.
    • 7. Risica PM, Schraer C, Ebbesson SO, Nobmann ED, Caballero B. Overweight and Obesity Among Alaskan Eskimos of the Bering Straits Region: the Alaska Siberia Project. Int J Obes Relat Metab Disord 2000; 24(8): 939-44.
    • 8. Risica PM, Ebbesson SO, Schraer CD, Nobmann ED, Caballero BH. Body Fat Distribution in Alaskan Eskimos of the Bering Straits Region: the Alaskan Siberia Project. Int J Obes Relat Metab Disord 2000; 24(2): 171-9.
    • 9. Ebbesson SOE, Kennish J, Ebbesson LOE, Go O, Yeh J. Diabetes is related to fatty acid imbalance in Eskimos. Int J Circumpolar Health 1999; 58: 108-119.
    • 10. Tuomilehto J, Lindstrom J, Eriksson JG, et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med (2001; 344: 1343-50.
    • 11. Eriksson KF, Lindgarde F. Prevention of type 2 (noninsulin-dependent) diabetes mellitus by diet and physical exercise: the 6-year Malmo feasibility study. Diabetlogia 2001; 34: 891-8.
    • 12. Wadden TA, Sternberg JA, Letizia KA, Stunkard AJ, Foster GD. Treatment of obesity by very low calorie diet, behavior therapy and their combination: a fiveyear perspective. Int J Obes 1989; 13: Suppl 2: 39-46.
    • 13. Pan XR, Li GW, Hu YH, et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. Diabetes Care 1997; 20: 537-44.
    • 14. Mouratoff GJ, Carroll NV, Scott EM: Diabetes mellitus in Eskimos. JAMA 1967; 199: 107-112.
    • 15. Lee ET, Welty TK, Fabitz R, et al. The Strong Heart Study-a study of cardiovascular disease in American Indians: design and methods. Amer J Epidem 1990; 132: 1141-55.
    • 16. Schraer CD, Risica PM, Ebbesson SOE, Go OT, Howard BV. Low fasting insulin levels in Eskimos compared to American Indians: Are Eskimos less insulin resistant? Int J Circumpolar Health 1999; 58: 272-280.
    • 17. Schraer CD, Ebbesson SOE, Boyko EJ, Nobmann ED, Adler A, Cohen JS. Hypertension and diabetes among Siberian Yupik Eskimos of St. Lawrence Island, Alaska. Public Health Reports 1996; Vol II, Supplement 42-44.
    • 18. Worlds Health Organization: Diabetes Mellitus: Report of a WHO Study Group. Geneva, World Health Org. (1985).Tech. Rep. Ser., no.727.
    • 19. Risica PM, Nobmann ED, Caulfield LE, Schraer C, Ebbesson SOE. Springtime macronutrient intake of Alaska Natives of the Bering Straits region: the Alaska Siberia Project. Int J Circumpolar Health 2005: 64(3): 222-233.
    • 20. Nobmann ED, Ebbesson SOE, White RG, Bulkow LR, Schraer CD. Association between dietary factors and plasma lipids related to cardiovascular disease among Siberian Yupiks of Alaska. Int J Circumpolar Health 1999; 58:254-271.
    • 21. Nobmann ED, Ebbesson SOE, White RG, et al. Dietary intakes among Siberian Yupiks of Alaska and implications for cardiovascular disease. Int J Circumpolar Health 1998; 57: 4-17.
    • 22. Dewailly E, Blanchet C, Lemieux S, et al. n-3 Fatty acids and cardiovascular disease risk factors among the Inuit of Nunavik, Am J Clin Nutr 2001; 2001: 74:464-73.
    • 23. Bennett PH, Knowler WC, Baird HR, Butler WJ, Pettitt DJ, Reid JM. Diet and development of non-insulin-dependent diabetes mellitus: an opidemiological perspective. In Diet, Diabetes and Atherosclerosis 1984; 109-119. Raven Press New York.
    • 24. Howard BV. Dietary Fatty Acids, Insulin Resistance, and Diabetes. Ann N Y Acad Sci 1997 Sep 20; 827:215-220.
    • 25. Feskins EJM, Khomhout. Habitual dietary intake and glucose tolerancein euglycemic men: the Zutphen Study. Int J Epidemiol 1990; 19: 953-959.
    • 26. Nissinen A, Khomhout D, Dietary factors determining diabetes and impaired glucose tolerance: a 20- year follow-up of the Finnish and Dutch cohorts of the Seven Countries Study. Diabetes Care 1995; 18: 1104-12.
    • 27. Chan JM, Rimm EB, Colditz GA, Stampfer MJ, Willett WC. Obesity, fat distribution, and weight gain as risk ractors for clinical diabetes in men. Diabetes Care 1994; 17(9): 961-69.
    • 28. O'Dea K. Marked improvement in carbohydrate and lipid metabolism in diabetic Austrailian Aborigines after temporary reversion to traditional lifestyle. Diabetes 1984; 33(6): 596-603.
    • 29. Kawate H, Yamakido M, Nishimoto Y, Bennett PH, Hanman RF, Knowler WC. Diabetes mellitus and its vascular complications in Japanese migrants on the island of Hawaii. Diabetes Care1979; 2(2): 161-170.
    • 30. Ravussin H, Valencia ME, Espanza J, Bennett PH, Schulz LO. Effects of a traditional lifestyle on obesity in Pima Indians. Diabetes Care1994; 17(9): 106?- 1074.
    • 31. Lovejoy J, DiGirolamo M, Habitual dietary intake and insulin sensitivity in lean and obese adults. Am J Clin Nutr 1992; 55: 1174-1179.
    • 32. Parker DR, Weiss ST, Trom R, Cassano PA, Vokonas PS, Landeberg L. Relationship of dietary saturated fatty acids and body habitus to serum insulin concentration: the Normative Aging Study. Am J Clin Nutr 1993; 38(2): 129-136.
    • 33. Mayer EJ, Newman B, Quesenberay CB, Selby JV, Usual dietary fat intake and insulin concentrations in healthy women twins. Diabetes Care1993; 16(11): 1459-1469.
    • 34. Feskins EJM, Lorber JG, Khomhout D, Diet and physical activity as determinants of hyperinsulinemia: the Zutphen Elderly Study, Am J Epidemiol 1994; 140: 350-360.
    • 35. Storlien LH, Kriketos AD, Jenkins AB, et al. Does dietary fat influence insulin action? Ann N Y Acad Sci 1997 sep 20; 827: 287-301.
    • 36. Ward KD, Sparrow D, Vokonas PS, Willett WC, Landsberg L, Weiss ST. The relationships of abdominal obesity, hyperinsulinemia, and saturated fat intake to serum lipid levels: the Normative Aging Study. Int J Obes 1994 ; 18 : 137-144.
    • 37. Boreman M, Stoblien LH, Pan PA, Jenkins AB, Chisholm DJ, Campbell VC. The relation between Insulin sensitivity and the fatty acid composition of skeletal musclephospholipids. Engl J Med 1993; 328(4): 238-244.
    • 38. Connor WE, Prince MJ, Ulemann D, et al. The hypotriglyceridemic effect of fish oil in adult-onset diabetes without adverse glucose control. Ann N Acad Sci 1993; 683: 337-340.
    • 39. McVeigh GE, Brennan GM, Cohn JN, Finkelstein SM, Hayes RJ, Johnston GD. Fish ol improves acterial compliance in non-insulin-dependent diabetes mellitus (DM). Arterioscler Thromb1994; 14(9): 1425- 1429.
    • 40. Feskens EJ, Virtanen SM, Rasanen L, et al. Dietary factors determining diabetes and impaired glucose tolerance. A 20-year follow-up of the Finnish and Dutch cohorts of the Seven Countries Study. Diabetes Care 1995;18:1104-12.
    • 41. Morgan WA, Raskin P, Rosenstock J. A comparison of fish oil or corn oil supplements in hypertripedemic subjects with DM. Diabetes Care 1995; 18(1): 83-86.
    • 42. Puhakainen I, Ahola I, Yki-Järvinen H. Dietary supplementation with n-3 fatty acids increases gluconeogenesis from glycerol but not hepatic glucose production I patients with non-insulin-dependent diabetes mellitus. Am J Clin Nutr 1995; 61: 121-126.
    • 43. Adler A, Schraer CD, Boyko EJ, Murphy NJ. Lower prevalence of impaired glucose tolerance and diabetes associated with daily seal oil or salmon consumption among Alaskan Natives. Diabetes Care , 1994; 17:1498-1501.
    • 44. Maedler K, Spinas GA, Dyntar D, Moritz W, Kaiser N, Donath MY. Distinct effects of saturated and monounsaturated fatty acids on B-cell turnover and function. Diabetes 2001; 50: 69-76.
    • 45. Lemaitre RN, King IB, Raghunathan TE, et al. Cell membrane trans-fatty acids and the risk of primary cardiac arrest. Circulation 2000; 105 (6): 697-701.
    • 46. de Roos NM, Bots ML, Katan MB. Replacement of dietary saturated fatty acids by trans-FAtty acids lowers serum HDL cholesterol and impairs endothelial function in health men and women. Arteriosclerosis, Thrombosis & Vascular Biology 2001; 21(7):1233-7.
    • 47. Stender S, Dyerberg J. The importance of trans-fatty acids for health. Ugeskrift for Laeger 2001; 163(17): 2349-53.
    • 48. Oomen CM, Ocke MC, Feskens EJ, van Erp-Baart MA, Kok FJ, Kromhout D. Association between trans-FAtty acid intake and 10-year risk of coronary heart disease in the Zutphen Elderly Study: a prospective population-based study. Lancet 2001; 357(9258):746-51.
    • 49. de Roos N, Schouten E. Katan M. Consumption of a solid fat rich in lauric acid results in a more favorable serum lipid profile in healthy men and women than consumption of a solid fat rich in trans-fatty acids. Journal of Nutrition 2001; 131 (2): 242-5.
    • 50. Williams MA, King IB, Sorensen TK, et al. Risk of preeclampsia in relation to elaidic acid (trans-FAtty acid) in maternal erythrocytes. Gynecologic & Obstetric Investigation 1998; 46(2): 84-7.
    • 51. Gillman MW, Cupples LA, Gagnon D, Millen BE, Ellison RC, Castelli WP. Margarine intake and subsequent coronary heart disease in men. Epidemiology 1997; 8(2): 122-3.
    • 52. Lemaitre RN, King IB, Patterson RE, Psaty BM, Kestin M, Heckbert SR. Assessment of trans-fatty acid intake with a food frequency questionnaire and validation with adipose tissue levels of trans-fatty acids. Am J Epidemiol 1998; 148(11): 1085-93.
    • 53. Pedersen JI, Johansson L, Thelle DS. Trans-fatty acids and health. Tidsskrift for Den Norske Laegeforening 1998; 118(22): 3474-80.
    • 54. Zock PL, Katan MB. Butter, margarine and serum lipoproteins. Atherosclerosis 1997; 131(1): 7-16.
    • 55. Zock PL, Katan MB. Trans-Fatty acids, lipoproteins, and coronary risk. Canadian Journal of Physiology & Pharmacology 1997; 75(3): 211-6.
    • 56. Lovejoy JC. Dietary fatty acids and insulin resistance. Current Atherosclerosis Reports 1999; 1(3): 215- 20.
    • 57. Hu FB, Stampfer MJ, Manson JE, et al. Dietary fat intake and the risk of coronary heart disease in wom en. N Engl J Med 1990; 337: 1491-1499 .
    • 58. Simopoulos AP.Evolutionary aspects of omega-3 fatty acids in the food supply. Prostaglandins Leukotrienes & Essential Fatty Acids 1999; 60(5-6): 421-9.
    • 59. Ebbesson SOE, Adler AI, Schraer CD, et al. Cardiovascular disease in three Alaskan Eskimo populations: The Alaska-Siberia Project. Int J Circumpolar Health 2005; 64 (4):365-386.
    • 60. Howard BV, Lee ET, Cowan LD, Devereaux RB, Galloway JM, Go DT, Howard WJ, Rhoades ER, Robbins DC, Sierers ML, Welty TK, Rising tide of Cardiovascular Disease in American Indians. The Strong Heart Study. Circulation 1999; 99:2389-2395.
    • 61. Bjerregaard P. Geographic variations of mortality in Greenland. Arctic Med Res 1990; 49:16-24.
    • 62. Schraer CD, Bulkow LR, Murphy NJ, et al. Diabetes prevalence, incidence, and complications among Alaskan Natives. Diabetes Care 1993; 16(suppl 1):257-259.
    • 63. Trimble B, Wainwright K, Lanier AP. Stroke in Yup'ik Eskimos. Presented at the American Academy of Neurology, Scientific Session on Neuroepidemiology of Stroke, Toronto, Canada, April, 1999.
    • 64. Howard BV, Lee ET, Cowan LD, et al. Coronary heart disease prevalence and its relation to risk factors in American Indians. Am J Epid 1995; 142:254- 268.
    • 65. Young TK, Schraer CD, Shubnikoff EV, et al. Prevalence of diagnosed diabetes in circumpolar indigenous populations. Int J Epidem 1992; 21:730-736.
    • 66. GISSI-Prevenzione Investigators. Dietary supplementation with omega-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: Results of the GISSI-prevenzione Trial. Lancet 1999; 354:447- 455.
    • 67. Harris SH, von SchackyClemens. The Omega-3 index: a new risk factor for death from coronary heart disease? Preventive Med 2004. In Press.
    • 68. Ebbesson SOE, Risica PM, Ebbesson LOE, Kennish JM. Tejero ME. Omega-3 Fatty Acids improve glucose tolerance and components of the metabolic syndrome in Alaskan Eskimos: The Alaska Siberia Project . Int J Circumpolar Health 2005; 64(4): 396-408.
    • 69. Knowler WC, Barrett-Conner E, Fowler SE et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. New England J Med 2002;346:393-403.
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