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Nord, C. E.; Edlund, C. (2011)
Publisher: Microbial Ecology in Health and Disease
Journal: Microbial Ecology in Health and Disease
Languages: English
Types: Article
Administration of antimicrobial agents may seriously disturb the balance of the normal intestinal microflora. This may cause bacterial overgrowth and emergence of resistant microorganisms which may lead to serious infections and also encourage transfer of resistance factors among bacteria. This review article summarises published scientific reports on the ecological effect of penicillins, cephalosporins, monobactams, carbapenems, macrolides, tetracyclines, nitroimidazoles, clindamycin and quinolones on the human intestinal microflora.Keywords: Ecology; Intestinal microflora; Antimicrobial agents.
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    • 1. Alestig K, Carlberg H, Nord CE, Trollfors B. (1983). Effect of cefoperazone on faecal flora. Journal of Antimicrobial Chemotherapy 12,163-1 67.
    • 2. Bartlett JB, Bustetter LA, Gorbach SL, Onderdonk AB. (1975). Comparative effect of tetracycline and doxycycline on the occurrence of resistant Escherichia coli in the fecal flora. Antimicrobial Agents and Chemotherapy 7,55-57.
    • 3. Bergan T, Delin C, Johansen S, Kolstad IM, Nord CE, Thorsteinsson SB. (1986). Pharmacokinetics of ciprofloxacin and effect of repeated dosage on salivary faecal microflora. Antimicrobial Agents and Chemotherapy 29,298-302.
    • 4. Brumfitt W, Franklin I, Grady D, Hamilton JMT. (1986). Effect of amoxicillin-clavulanate and cephradine on the fecal flora of healthy volunteers not exposed to a hospital environment. Antimicrobial Agents and Chemotherapy 30,335-337.
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    • 6. Chida T, Shibaoka H, Ishizuka I, Nakaya R. (1984). The effect of ofloxacin (DL8280), a new antibacterial agent of pyridonecarboxylic acid derivative, on human fecal flora. Chemotherapy 32, 109-1 17.
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    • 8. De Vries-Hospers HG, Welling GW, van der Waaij D. (1985). Norfloxacin for selective decontamination. A study in human volunteers. Progress in Clinical and Biological Research 181,259-262.
    • 9. Edlund C, Bergan T, Josefsson K, Solberg R, Nord CE. (1987). Effect of norfloxacin on human oropharyngeal and colonic microflora and multipledose pharmacokinetics. Scandinavian Journal of Infectious Diseases 19, 113-121.
    • 10. Edlund C, Brismar B, Nord CE. (1990). Effect of lomefloxacin on the normal oral and intestinal microflora. European Journal of Clinical Microbiology and Infectious Diseases 9,35-39.
    • 1 1 . Edlund C, Lidbeck A, Kager L, Nord CE. (1987). Effect of enoxacin on colonic microflora of healthy volunteers. European JournaI of Clinical Microbiology 6,298-300.
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    • 17. Heimdahl A, Nord CE. (1979). Effect of phenoxymethylpenicillin and ciindamycin on the oral, throat and faecal microflora on man. Scandinavian Journal of Infectious Diseases 11,233-242.
    • 18. Heimdahl A, Nord CE. (1983). Influences of doxycycline on the normal human flora and colonization of the oral cavity and colon. Scandinavian Journalof Infectious Diseases 15,293-302.
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    • 20. Heimdahl A, Nord CE, Weilander K. (1979). Effect of bacampicillin on human mouth, throat and colon flora. Infection 7, S44M51.
    • 21. Holt HA, Lewis DA, White LO, Bastable SY, Reeves DS. (1986). Effect of oral ciprofloxacin on the faecal flora of healthy volunteers. European Journal of Clinical Microbiology 5,201-205.
    • 22. Jones PG, Bodey GP, Swabb EA, Rosenbaum B. (1984). Effect of aztreonam on throat and stool flora of cancer patients. Antimicrobial Agents and Chemotherapy 26,941-943.
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    • 24. Knothe H, Dette GA, Shah PM. (1985). Impact of injectable cephalosporins on the gastrointestinal microflora. Observations in healthy volunteers and hospitalized patients. Infection 13,S129-133.
    • 25. Knothe H, Lembke U. (1973). The effect of ampicillinandpivampicillinon theintestinal microflora of man. Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. Series A A223,324-332.
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    • 33. Lode H, Miiller C, Borner K, Nord CE, Koeppe P. (1991). Cephrocile: multiple-dose pharmacokinetics and impact on the intestinal flora in volunteers. Antimicrobial Agents and Chemotherapy (in press).
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