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Sacco, Frank; Bruce, Michael G.; McMahon, Brian J.; Bruden, Dana (2007)
Publisher: Co-Action Publishing
Journal: International Journal of Circumpolar Health
Languages: English
Types: Article
Subjects: Alaska Native; endoscopy; gastric cancer; gastritis,; Helicobacter pylori; ulcer
OBJECTIVES: To characterize the nature and prevalence of disease in Alaska Native patients referred for evaluation of upper gastrointestinal signs and symptoms. STUDY DESIGN: Cross-sectional. METHODS: Two hundred consecutive Alaska Native patients referred to a statewide tertiary center were prospectively evaluated. A standardized data collection form documenting EGD findings was utilized. Routine biopsies of the antrum and fundus were taken on all patients. Additional tissue was obtained from any areas of clinical concern. RESULTS: Among 200 patients who underwent EGD during the study period, 130 (65%) tested H. pylori-positive on histology. Among 173 patients with histologic evidence of gastritis, 114 (66%) tested H. pylori-positive on histology. Chronic gastritis (87%), gastric ulcer (GU 12%), duodenal ulcer (DU 3%) and gastric cancer (2%) were the predominant findings. The GU:DU ratio was 4:1, the inverse of that reported in the general U.S. population. CONCLUSIONS: Alaska Native patients referred for upper endoscopy have a high rate of H. pylori infection with predominantly gastric manifestations of disease and a GU:DU ratio, which is the inverse of what is typically seen in the U.S. and other developed countries. The high prevalence of H. pylori in Alaska Native patients resembles prevalence patterns reported from developing countries and may be linked to a rate of gastric cancer that is over three times that found in the U.S. population at large.Keywords: Alaska Native; endoscopy; gastric cancer; gastritis,; Helicobacter pylori; ulcer(Int J Circumpolar Health 2007; 66(2):144-152)
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    • 1. Sonnenberg A. Geographic and temporal variations in the occurrence of peptic ulcer disease. Scand J Gastroenterol Suppl. 1985;110:11-24.
    • 2. Thompson WM, Ackerstein H. Peptic ulcer disease in the Alaska Natives: a four-year retrospective study. Alaska Med. 1975;17(3):43-44.
    • 3. Thompson WM, Ackerstein H. Peptic ulcer disease in the Alaska Natives: a four-year (1967-1971) retrospective study. Alaska Med. 2005;47(1):22.
    • 4. Lanier AP, Kelly JJ, Maxwell J, McEvoy T, Homan C. Cancer in Alaska Native People, 1969-2003. Alaska Med. 2006;48(2):30-59.
    • 5. Alberts SR, Kelly JJ, Lanier AP et al. Occurrence of esophageal and gastric cancer in Alaska Natives, 1969-2003. Alaska Med. 2006;48(1):2-11.
    • 6. Personal correspondence from Dr David Graham, 1994.
    • 7. Leon-Barua R, Recavarren-Arce S. et al. Helicobacter pylori and gastric cancer. Rev. Gastroenterol Peru. 1995; ?? (Suppl 1):S23-27.
    • 8. Fenger HJ, Gudmand-Hoyer E. Peptic ulcer in Greenland Inuit: evidence for a low prevalence of duodenal ulcer. Int J Circumpolar Health 1997;56(3): 64-69.
    • 9. y ip R, Limburg PJ, Ahlquist DA et al. Pervasive occult gastrointestinal bleeding in an Alaska native population with prevalent iron deficiency. Role of Helicobacter pylori gastritis. JAMA. 1997;277(14):1135-1139.
    • 10. Blaser MJ, Chyou PH, Nomura A. Age at establishment of Helicobacter pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk. Cancer Res. 1995;55(3):562-565.
    • 11. Parkinson AJ, Gold BD, Bulkow L et al. High prevalence of Helicobacter pylori in the Alaska Native population and association with low serum ferritin levels in young adults. Clin Diagn Lab Immunol. 2000;7(6): 885-888.
    • 12. Koch A, Krause TG, Krogfelt K, Olsen OR, Fischer TK, Melbye M. Seroprevalence and risk factors for Helicobacter pylori infection in Greenlanders. Helicobacter. 2005;10(5):433-442.
    • 13. Miernyk KM, Bruden DL, Bruce MG et al. Dynamics of Helicobacter pylori-specific Immunoglobulin G for two years after successful eradication of Helicobacter pylori infection in an American Indian and Alaska Native population. Clin Vaccine Immunol. 2007;14(1):00-00.
    • 14. Wong BCy , Lam S, Wong W-M et al. Eradication of Helicobacter pylori infection significantly slows down the progression of precancerous lesions in a high risk population: A 5-year prospective randomized study. Gastroenterology 2002;122:A588.
    • 15. Correa P, Fontham ET, Bravo JC et al. Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and anti-helicobacter pylori therapy. J Natl Cancer Inst. 2000;92(23):881-1888.
    • 16. Nozaki K, Shimizu N, Ikehara y et al. Effect of early eradication on Helicobacter pylori-related gastric carcinogenesis in Mongolian gerbils. Cancer Sci. 2003;94 (3):235-239.
    • 17. Lacy BE, Rosemore J. Helicobacter pylori; ulcers and more: the beginning of an era. J Nutr. 2001;131:2789S2793S.
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