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Riccardi, Gabriele; Bozzetto, Lutgarda; Annuzzi, Giovanni (2006)
Publisher: Co-Action Publishing
Journal: Food & Nutrition Research
Languages: English
Types: Article

Classified by OpenAIRE into

mesheuropmc: lipids (amino acids, peptides, and proteins)
Atherogenic effects of postprandial lipoproteins are supported by many studies comparing patients with advanced clinical signs or early markers of cardiovascular disease with subjects without vascular disease. Postprandial lipoprotein abnormalities are more frequent in individuals with type 2 diabetes and other states of insulin resistance, which could be a major factor accounting for the higher rate of cardiovascular diseases observed in these conditions. In patients with type 2 diabetes multiple abnormalities of lipoproteins of both endogenous and exogenous origin are observed also in the presence of good blood glucose control and normal fasting triglyceridaemia, and a direct role of insulin resistance in the development of postprandial dyslipidaemia has been demonstrated. Clinical and experimental studies have demonstrated that a high fat consumption is associated with impaired insulin sensitivity and may worsen postprandial hypertriglyceridemia in individuals with type 2 diabetes and/or hyperlipidaemia. In addition to the amount of fat also the physical structure of the food in which fat is present is able to influence postprandial lipaemia. Data on the effects of dietary fatty acid (FA) modifications in humans are scarce. These studies have provided some evidence that dietary polyunsaturated FA, particularly those of the n-3 class, induce an attenuated postprandial lipaemic response as compared to saturated FA (SFA) and monounsaturated FA (MUFA); however, the data are often conflicting and their interpretation is, generally, controversial. Very little is known in patients with type 2 diabetes, in whom both insulin sensitivity and postprandial lipaemia are particularly relevant. In a medium term (3 weeks) study in type 2 diabetic patients, a MUFA rich diet did not modify insulin sensitivity as compared to the SFA rich diet. The MUFA diet induced a higher early peak of chylomicrons and a significantly lower postprandial response o f small VLDL after a standard test meal, rich in saturated fat. In conclusion, postprandial lipoprotein abnormalities are a frequent feature of type 2 diabetes and of other conditions clustering with insulin resistance. The total amount of fat, more than the specific type of fatty acid, seems to influence postprandial lipoproteins. Data are needed on long term interventions as well as on the interactions between dietary fat and other food components or physical structure. Keywords: postprandial lipoproteins; metabolism of dietary fat
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 1. Redgrave TR. Formation of cholesteryl ester-rich particulate lipid during metabolism of chylomicrons. J Clin Invest 1970; 49: 465 71.
    • 2. Cooper AD. Hepatic uptake of chylomicron remnants. J Lipid Res 1997; 38: 2173 92.
    • 3. Zilversmit DB. Atherogenesis: a postprandial phenomenon. Circulation 1979; 60: 473 85.
    • 4. Groot PH, van Stiphout WA, Krauss XH, Jansen H, van Tol A, van Ramshorst E, et al. Postprandial lipoprotein metabolism in normolipidemic men with and without coronary artery disease. Arterioscler Thromb 1991; 11: 653 62.
    • 5. Patsch JR, Miesenbock G, Hopferwieser T, Muhlberger V, Knapp E, Dunn JK, et al. Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state. Arterioscler Thromb 1992; 12: 1336 45.
    • 6. Karpe F, Steiner G, Uffelman K, Olivecrona T, Hamsten A. Postprandial lipoproteins and progression of coronary atherosclerosis. Atherosclerosis 1994; 106: 83 97.
    • 7. Weintraub MS, Grosskopf I, Rassin T, Miller H, Charach G, Rotmensch HH, Liron M, et al. Clearance of chylomicron remnants in normolipidaemic patients with coronary artery disease: case control study over three years. BMJ 1996; 312: 936 9.
    • 8. Lupattelli G, Pasqualini L, Siepi D, Marchesi S, Pirro M, Vaudo G, et al. Increased postprandial lipemia in patients with normolipemic peripheral arterial disease. Am Heart J 2002; 14: 733 8.
    • 9. Ryu JE, Howard G, Craven TE, Bond MG, Hagaman AP, Crouse JR III. Postprandial triglyceridemia and carotid atherosclerosis in middle-aged subjects. Stroke 1992; 23: 823 8.
    • 10. Sharrett AR, Chambless LE, Heiss G, Paton CC, Patsch W. Association of postprandial triglyceride and retinyl palmitate responses with asymptomatic carotid artery atherosclerosis in middle-aged men and women. The Atherosclerosis Risk in Communities (ARIC) Study. Arterioscler Thromb Vasc Biol 1995; 15: 2122 9.
    • 11. Karpe F, de Faire U, Mercuri M, Bond MG, Hellenius ML, Hamsten A. Magnitude of alimentary lipemia is related to intima-media thickness of the common carotid artery in middle-aged men. Atherosclerosis 1998; 141: 307 14.
    • 12. Boquist S, Ruotolo G, Tang R, Bjorkegren J, Bond MG, de Faire U, et al. Alimentary lipemia, postprandial triglyceride-rich lipoproteins, and common carotid intima-media thickness in healthy, middle-aged men. Circulation 1999; 100: 723 8.
    • 13. Karpe F, Boquist S, Tang R, Bond GM, de Faire U, Hamsten A. Remnant lipoproteins are related to intimamedia thickness of the carotid artery independently of LDL cholesterol and plasma triglycerides. J Lipid Res 2001; 42: 17 21.
    • 14. Yu KC, Cooper AD. Postprandial lipoproteins and atherosclerosis. Front Biosci 2001; 6: D332 54.
    • 15. Ross R. Atherosclerosis is an inflammatory disease. Am Heart J 1999; 138: S419 20.
    • 16. Mitropoulos KA, Miller GJ, Reeves BEA, Wilkes HC, Cruick-Shank JK. Factor VII coagulant activity is strongly associated with the plasma concentration of large lipoprotein particles in middle-aged men. Atherosclerosis 1989; 76: 203 8.
    • 17. Iovine C, Vaccaro O, Gentile A, Romano G, Pisanti F, Riccardi G, Rivellese AA. Post-prandial triglyceride profile in a population-based sample of type 2 diabetic patients. Diabetologia 2004; 47: 19 22.
    • 18. Rivellese AA, De Natale C, Di Marino L, Patti L, Iovine C, Coppola S, et al. Exogenous and endogenous postprandial lipid abnormalities in type 2 diabetic patients with optimal blood glucose control and optimal fasting triglyceride levels. J Clin Endocrinol Metab 2004; 89: 2153 9.
    • 19. Annuzzi G, De Natale C, Iovine C, Patti L, Di Marino L, Coppola S, et al. AA. Insulin resistance is independently associated with postprandial alterations of triglyceride-rich lipoproteins in type 2 diabetes mellitus. Arterioscler Thromb Vasc Biol 2004; 24: 2397 402.
    • 20. van Oostrom AJ, van Dijk H, Verseyden C, Sniderman AD, Cianflone K, Rabelink TJ, Castro Cabezas M. Addition of glucose to an oral fat load reduces postprandial free fatty acids and prevents the postprandial increase in complement component 3. Am J Clin Nutr 2004; 79: 510 5.
    • 21. Clemente G, Mancini M, Nazzaro F, Lasorella G, Rivieccio A, Palumbo AM, et al. Effects of different dairy products on postprandial lipemia. Nutr Metab Cardiovasc Dis 2003; 13: 377 83.
    • 22. Thomsen C, Rasmussen O, Lousen T, Holst JJ, Fenselau S, Schrezenmeir J, Hermansen K. Differential effects of saturated and monounsaturated fatty acids on postprandial lipemia and incretin responses in healthy subjects. Am J Clin Nutr 1999; 69: 1135 43.
    • 23. Mekki N, Charbonnier M, Borel P, Leonardi J, Juhel C, Portugal H, Lairon D. Butter differs from olive oil and sunflower oil in its effects on postprandial lipemia and triacylglycerol-rich lipoproteins after single mixed meals in healthy young men. J Nutr 2002; 132: 3642 9.
    • 24. Silva KD, Kelly CN, Jones AE, Smith RD, Wootton SA, Miller GJ, Williams CM. Chylomicron particle size and number, factor VII activation and dietary monounsaturated fatty acids. Atherosclerosis 2003; 166: 73 84.
    • 25. Rivellese AA, Iovine C, Ciano O, Costagliola L, Galasso R, Riccardi G, Vaccaro O. Nutrient determinants of postprandial triglyceride response in a population-based sample of type 2 diabetic patients. Eur J Clin Nutr 2006;60:1168 73 [Epub 10 May 2006].
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