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Willett, Walter C. (2003)
Publisher: Co-Action Publishing
Journal: Food & Nutrition Research
Languages: English
Types: Article
The percentage of dietary energy from fat has been suggested to be an important determinant of body fat, and this presumed effect has been used to promote low-fat diets. In short-term randomized trials, a small reduction in body weight is typically seen in individuals randomized to diets with a lower percentage of calories from fat. However, in trials lasting for 1 year or longer, fat consumption within the range of 18-40% of energy had consistently had little if any effect on body fatness. The weighted mean difference was -0.25 kg overall and +1.8 kg for trials with a control group that received a comparable intensity intervention (i.e. less weight loss on the low-fat diets). Moreover, in the USA and other affluent countries, a substantial decline in the percentage of energy from fat during the past two decades has corresponded with a massive increase in obesity. Diets high in fat do not account for the high prevalence of excess body fat in Western countries; red uctions in the percentage of energy from fat will have no important benefits and could further exacerbate this problem. Keywords: adiposity; diet; fat; obesity; overweight
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    • 1. Willett W. Dietary fat plays a major role in obesity: no. Obes Rev 2002; 3: 59 /68.
    • 2. Willett WC, Manson JE, Stampfer MJ, et al. Weight, weight change, and coronary heart disease in women: risk within the ''normal'' weight range. JAMA 1995; 273: 461 /5.
    • 3. Grundy SM. How much does diet contribute to premature coronary heart disease? In: Stein O, Stein Y, eds. Atherosclerosis IX. Proceedings of the 9th International Symposium on Atherosclerosis. Tel Aviv: Creative Communications; 1992. p. 471 /8.
    • 4. Willett WC, Dietz WH, Colditz GA. Guidelines for healthy weight. N Engl J Med 1999; 341: 427 /34.
    • 5. Colditz GA, Willett WC, Rotnitzky A, Manson JE. Weight gain as a risk factor for clinical diabetes in women. Ann Intern Med 1995; 122: 481 /6.
    • 6. Felson DT. Weight and osteoarthritis. Am J Clin Nutr 1996; 63(Suppl): 430 /2.
    • 7. Seidell JC. Time trends in obesity: an epidemiological perspective. Horm Metab Res 1997; 29: 155 /8.
    • 8. Kato H, Tillotson J, Nichaman MZ, et al. Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California. Am J Epidemiol 1973; 97: 372 /85.
    • 9. Flegal KM, Larkin FA. Partitioning macronutrient intake estimates from a food frequency questionnaire. Am J Epidemiol 1990; 131: 1046 /58.
    • 10. Bray GA, Popkins BM. Dietary fat intake does affect obesity! Am J Clin Nutr 1998; 68: 1157 /73.
    • 11. Kuczmarski RJ, Flegal KM, Campbell SM, Johnson CL. Increasing prevalence of overweight among US adults. The National Health and Nutrition Examination Surveys, 1960 to 1991. JAMA 1994; 272: 205 /11.
    • 12. National Research Council / Committee on Diet and Health. Diet and health: implications for reducing chronic disease risk. Washington, DC: National Academy Press; 1989.
    • 13. World Cancer Research Fund, American Institute for Cancer Research. Food, nutrition and the prevention of cancer: a global perspective. Washington, DC: American Institute for Cancer Research; 1997.
    • 14. Astrup A, Grunwald GK, Melanson EL, et al. The role of low-fat diets in body weight control: a meta-analysis of ad libitum dietary intervention studies. Int J Obes 2000; 24: 1545 /52.
    • 15. Astrup A. Macronutrient balances and obesity: the role of diet and physical activity. Public Health Nutr 1999; 2: 341 /7.
    • 16. Pi-Sunyer FX. Effect of the composition of the diet on energy intake. Nutr Rev 1990; 48: 94 /105.
    • 17. Gershoff SN. Nutrition evaluation of dietary fat substitutes. Nutr Rev 1995; 53: 305 /13.
    • 18. Astrup A. Dietary composition, substrate balances and body fat in subjects with a predisposition to obesity. Int J Obes 1993; 17(Suppl 3): S32 /6.
    • 19. Flatt JP. Energetics of intermediary metabolism. In: Garrow JS, Halliday D, eds. Substrate and energy metabolism in man. London: John Libbey; 1985. p. 58 /69.
    • 20. McDevitt RM, Poppitt SD, Murgatroyd PR, Prentice AM. Macronutrient disposal during controlled overfeeding with glucose, fructose, sucrose, or fat in lean and obese women. Am J Clin Nutr 2000; 72: 369 /77.
    • 21. Lissner L, Heitmann BL. Dietary fat and obesity: evidence from epidemiology. Eur J Clin Nutr 1995; 49: 79 /90.
    • 22. Chen J, Campbell TC, Junyao L, Peto R. Diet, life-style, and mortality in China: a study of the characteristics of 65 Chinese counties. Oxford: Oxford University Press; 1990.
    • 23. Willett WC. Dietary fat and obesity: an unconvincing relation (Editorial). Am J Clin Nutr 1998; 68: 1149 /50.
    • 24. Centers for Disease Control and Prevention / National Center for 24. Health Statistics. Daily dietary fat and total food-energy intakes / Third National Health and Nutrition Examination Survey, Phase 1, 1988 / 91. MMWR Morb Mortal Wkly Rep 1994; 43(7): 116 /7.
    • 25. Lissner L, Levitsky DA, Strupp BJ, et al. Dietary fat and the regulation of energy intake in human subjects. Am J Clin Nutr 1987; 46: 886 /92.
    • 26. Dreon DM, Frey-Hewitt B, Ellsworth N, et al. Dietary fat:carbohydrate ratio and obesity in middle-aged men. Am J Clin Nutr 1988; 47: 995 /1000.
    • 27. Romieu I, Willett WC, Stampfer MJ, et al. Energy intake and other determinants of relative weight. Am J Clin Nutr 1988; 47: 406 /12.
    • 28. Tremblay A, Plourde G, Despres J-P, Bouchard C. Impact of dietary fat content and fat oxidation on energy intake in humans. Am J Clin Nutr 1989; 49: 799 / 805.
    • 29. George V, Tremblay A, Despres J-P, et al. Effect of dietary fat content on total and regional adiposity in men and women. Int J Obes 1990; 14: 1085 /94.
    • 30. Miller WC, Lindeman AK, Wallace J, Niederpruem M. Diet composition, energy intake, and exercise in relation to body fat in men and women. Am J Clin Nutr 1990; 52: 426 /30.
    • 31. Colditz GA, Willett WC, Stampfer MJ, et al. Patterns of weight change and their relation to diet in a cohort of healthy women. Am J Clin Nutr 1990; 51: 1100 /5.
    • 32. Tucker LA, Kano MJ. Dietary fat and body fat: a multivariate study of 205 adult females. Am J Clin Nutr 1992; 56: 616 /22.
    • 33. Slattery ML, McDonald A, Bild DE, et al. Associations of body fat and its distribution with dietary intake, physical activity, alcohol, and smoking in blacks and whites. Am J Clin Nutr 1992; 55: 943 /9.
    • 34. Pudel V, Westenhoefer J. Dietary and behavioural principles in the treatment of obesity. International Monitor on Eating Patterns and Weight Control. Medicom/Servier 1992; 1: 2 /7.
    • 35. Klesges RC, Klesges LM, Haddock CK, Eck LH. A longitudinal analysis of the impact of dietary intake and physical activity on weight change in adults. Am J Clin Nutr 1992; 55: 818 /22.
    • 36. Lissner L, Lindroos AK. Is dietary underreporting macronutrient-specific? Eur J Clin Nutr 1994; 48: 453 / 4.
    • 37. Rissanen AM, Heliovaara M, Knekt P, et al. Determinants of weight gain and overweight in adults Finns. Eur J Clin Nutr 1991; 45: 419 /30.
    • 38. Sheppard L, Kristal AR, Kushi LH. Weight loss in women participating in a randomized trial of low-fat diets. Am J Clin Nutr 1991; 54: 821 /8.
    • 39. Puska P, Iacono JM, Nissinen A, et al. Controlled, randomised trial of the effect of dietary fat on blood pressure. Lancet 1983; i: 1 /5.
    • 40. Hunninghake DB, Stein EA, Dujovne CA, et al. The efficacy of intensive dietary therapy alone or combined with lovastatin in outpatients with hypercholesterolemia. N Engl J Med 1993; 328: 1231 /9.
    • 41. Levitsky DA, Strupp BJ. Imprecise control of food intake on low fat diets. In: Fernstrom JD, Miller GD, eds. Appetite and body weight regulation: sugar, fat and macronutrients. Boca Raton, FL: CRC Press; 1994: 179 /90.
    • 42. Shah M, McGovern P, French S, Baxter J. Comparison of a low-fat ad libitum complex-carbohydrate diet with a low-energy diet in moderately obese women. Am J Clin Nutr 1994; 59: 980 /4.
    • 43. Schaefer EJ, Lichtenstein AH, Lamon-Fava S, et al. Body weight and low-density lipoprotein cholesterol changes after consumption of a low-fat ad libitum diet. JAMA 1995; 274: 1450 /5.
    • 44. Westerterp KR, Verboeket-van de Venne WP, Westerterp-Plantenga MS, et al. Dietary fat and body fat: an intervention study. Int J Obes Relat Metab Disord 1996; 20: 1022 /6.
    • 45. National Diet /Heart Study Research Group. The National Diet /Heart Study Final Report. Circulation 1968; 18(Suppl): 1 /154.
    • 46. Boyd NF, Cousins M, Beaton M, et al. Quantitative changes in dietary fat intake and serum cholesterol in women: results from a randomized controlled trial. Am J Clin Nutr 1990; 52: 470 /6.
    • 47. Kasim SE, Martino S, Kim PN, et al. Dietary and anthropometric determinants of plasma lipoproteins during a long-term low-fat diet in healthy women. Am J Clin Nutr 1995; 57: 146 /53.
    • 48. Black HS, Herd JA, Goldberg LH, et al. Effect of a lowfat diet on the incidence of actinic keratosis. N Engl J Med 1994; 330: 1272 /5.
    • 49. Jeffery RW, Hellerstedt WL, French SA, Baxter JE. A randomized trial of counseling for fat restriction versus calorie restriction in the treatment of obesity. Int J Obes 1995; 19: 132 /7.
    • 50. Simon M, Heilbrun L, Boomer A, et al. A randomized trial of a low-fat dietary intervention in women at high risk for breast cancer. Nutr Cancer 1997; 27: 136 /42.
    • 51. National Diet Heart Study Research Group. National Diet Heart Study Final Report. Circulation 1968; 37(Suppl 1): 1 /428.
    • 52. Knopp RH, Walden CE, Retzlaff BM, et al. Long-term cholesterol-lowering effects of 4 fat-restricted diets in hypercholesterolemic and combined hyperlipidemic men: the Dietary Alternatives Study. JAMA 1997; 278: 1509 /15.
    • 53. McManus K, Antinoro K, Sacks F. A randomized trial of moderate fat, low energy diet compared with a low fat, low energy diet for weight loss in overweight adults. Int J Obes 2001; 25: 1503 /11.
    • 54. Mensink RP, Katan MB. Effect of dietary fatty acids on serum lipids and lipoproteins: a meta-analysis of 27 trials. Arterioscler Thromb 1992; 12: 911 /9.
    • 55. Lee-Han H, Cousins M, Beaton M, et al. Compliance in a randomized clinical trial of dietary fat reduction in patients with breast dysplasia. Am J Clin Nutr 1988; 48: 575 /86.
    • 56. Powell JJ, Tucker L, Fisher AG, Wilcox K. The effects of different percentages of dietary fat intake, exercise, and calorie restriction on body composition and body weight in obese females. Am J Health Promot 1994; 8: 442 /8.
    • 57. Alford BB, Blankenship AC, Hagen RD. The effects of variations in carbohydrate, protein, and fat content of the diet upon weight loss, blood values, and nutrient intake of adult obese women. J Am Diet Assoc 1990; 90: 534 /40.
    • 58. Lehmann T, Golay A, James RW, Pometta D. Effects of two hypocaloric diets, fat restricted or rich in monounsaturated fat, on body weight loss and plasma lipoprotein distribution. Nutr Metab Cardiovasc Dis 1995; 5: 290 /6.
    • 59. Astrup A, Toubro S, Raben A, Skov AR. The role of low-fat diets and fat substitutes in body weight management: what have we learned from clinical studies? J Am Diet Assoc 1997; 97(Suppl): S82 /7.
    • 60. Flatt JP. The difference in the storage capacities for carbohydrate and for fat, and its implications in the regulation of body weight. Ann N Y Acad Sci 1987; 499: 104 /23.
    • 61. Flatt JP. Dietary fat, carbohydrate balance, and weight maintenance. Ann N Y Acad Sci 1993; 683: 122 /40.
    • 62. Ornish D, Brown SE, Scherwitz LW, et al. Can lifestyle changes reverse coronary heart disease? Lancet 1990; 336: 129 /33.
    • 63. Baer JT. Improved plasma cholesterol levels in men after a nutrition education program at the worksite. J Am Diet Assoc 1993; 93: 658 /63.
    • 64. Stefanick ML, Mackey S, Sheehan M, et al. Effects of diet and exercise in men and postmenopausal women with low levels of HDL cholesterol and high levels of LDL cholesterol. N Engl J Med 1998; 339: 12 /20.
    • 65. Yu-Poth S, Zhao G, Etherton T, et al. Effects of the National Cholesterol Education Program's Step I and Step II dietary intervention programs on cardiovascular disease risk factors: a meta-analysis. Am J Clin Nutr 1999; 69: 632 /46.
    • 66. Pirozzo S, Summerbell C, Cameron C, Glasziou P. Advice on low-fat diets for obesity. Cochrane Library Review. Issue 4. Oxford: Update Software; 2002.
    • 67. Kendall A, Levitsky DA, Strupp BJ, Lissner L. Weight loss on a low-fat diet: consequence of the imprecision of the control of food intake in humans. Am J Clin Nutr 1991; 53: 1124 /9.
    • 68. Shintani TT, Hughes CK, Beckman S, O'Connor HK. Obesity and cardiovascular risk intervention through the ad libitum feeding of a traditional Hawaiian diet. Am J Clin Nutr 1991; 6: 1647s /51s.
    • 69. Poppitt SD. Energy density of diets and obesity. Int J Obes ; (Suppl) 1995; 19: S20 /6.
    • 70. Sclafani A. Dietary obesity. In: Stunkard AJ, Wadden TA, eds. Obesity: theory and therapy. New York: Raven Press; 1993. p. 125 /36.
    • 71. Heitmann BL, Lissner L, Sorensen TI, Bengtsson C. Dietary fat intake and weight gain in women genetically predisposed for obesity. Am J Clin Nutr 1995; 61: 1213 / 7.
    • 72. Roberts SB. Abnormalities of energy expenditure and the development of obesity. Obes Res 1995; 3(Suppl 2): 155 /63.
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