LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Woolverton, C. J.; Holt, L. C.; Sartor, R. B. (2011)
Publisher: Microbial Ecology in Health and Disease
Journal: Microbial Ecology in Health and Disease
Languages: English
Types: Article
Subjects:
Germ-free and conventional mice were fed sterile peptidoglycan-polysaccharide polymers to determine whether intestinal bacterial cell wall products influence systemic immunity. Germ-free mice fed saline had significantly less footpad swelling after challenge with sheep erythrocytes than conventional mice. Feeding peptidoglycan-polysaccharide polymers to germ-free mice restored their deficient cellular immune response to conventional levels. Feeding peptidoglycan-polysaccharide did not alter anti-erythrocyte antibody production in germ-free mice. Spontaneous in vitro proliferation of unfractionated splenocytes taken from germ-free mice fed peptidoglycan-polysaccharide polymers was enhanced compared with proliferation of splenocytes from germ-free mice fed human serum albumin. In vitro conconavalin A stimulation of unfractionated splenocytes obtained from germ-free mice fed cell wall polymers resulted in a significant decrease in proliferation relative to that seen for germ-free mice fed human serum albumin. Respective proliferation results were abrogated when splenocytes were fractionated by removal of plastic-adherent cells. These results suggest that luminal peptidoglycan-polysaccharide polymers are important in the functional development of systemic cellular immunity, and that plastic-adherent splenocytes regulate this response.Keywords - Germ free, Peptidoglycan, Delayed-type hypersensitivity, Splenocyte proliferation, Immunoregulation.

Share - Bookmark

Cite this article

Collected from