LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Parrett, Alison M.; lokerse, Ella; Edwards, Christine A. (2011)
Publisher: Microbial Ecology in Health and Disease
Journal: Microbial Ecology in Health and Disease
Languages: English
Types: Article
Subjects:
The objective of this study was to determine the effect of weaning on the ability of formula-fed infants to ferment complex carbohydrates. A cross-sectional study of 46 infants was performed. Fresh faeces were collected from normal exclusively formula-fed infants at pre- (n=15), early (n=15) and late weaning (n=16). Faecal bacteria were incubated with simple and complex carbohydrates (glucose, lactose, raftilose and soyabean polysaccharide) in vitro. In addition, a control culture with no added carbohydrate was also incubated. Short-chain fatty acids (SCFA) and lactate were measured in culture supernatant after anaerobic incubation for 24 hours. There were no significant differences between any stages of weaning for SCFA production for any substrate. However, there was a consistent trend for the percentage of butyric acid production to increase with age. The greater similarity of the colonic flora of the formula-fed infants to that of the adult results in less impact of weaning on the development of fermentation capacity for complex carbohydrates than that previously reported for the simpler flora of the breast-fed infant.Key words: formula-fed, infant, fermentation, carbohydrate, weaning.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 1. Edwards CA, Parrett AM, Balmer SE, Wharton BA. Faecal short chain fatty acids in breast-fed and formula-fed babies. Acta Pediatr 1994; 83: 459 - 62.
    • 2. Kien CL, Liechty EA, Mullett MD. Contribution of lowmolecular weight compounds to the faecal excretion of carbohydrate energy in premature infants. Gastroenterology 1990; 99: 165 - 74.
    • 3. Rao SSC, Edwards CA, Austen C, Read NW, Holdsworth CD. Impaired colonic fermentation of carbohydrates after ampicillin. Gastroenterology 1988; 94: 928 - 32.
    • 4. Balmer SE, Wharton BA. Diet and faecal flora in the newborn: breast milk and infant formula. Arch Dis Child 1989; 64: 1672 - 7.
    • 5. Stark PL, Lee A. The microbiology of the large bowel of breast-fed and formula-fed infants during the first year of life. J Med Microbiol 1982; 15: 189 - 203.
    • 6. Harmsen HJ, Wildeboer-Veloo AC, Raangs GC, Wagendorp AA, Klijn N, Bindels JG, Welling GW. Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods. J Pediatr Gastroenterol Nutr 2000; 30: 61 - 7.
    • 7. Martin F, Savage SAH, Parret AM, Gramet G, Dore J, Edwards CA. Investigation of bacterial colonisation of the colon in breast-fed infants using novel techniques, Proc Nutr Soc 2000; 64.
    • 8. Adiotomre J, Eastwood MA, Edwards CA, Brydon WG. Dietary fibre; in vitro methods that anticipate nutrition and metabolic activity in humans. Am J Clin Nutr 1990; 68: 741 - 51.
    • 9. Parrett AM, Lokerse E, Edwards CA. Colonic fermentation in vitro: development during weaning in breast fed infants is slower for complex carbohydrates than for sugars. Am J Clin Nutr 1997; 65: 927 - 33.
    • 10. Midtvedt A-C, Carlstedt-Duke B, Norin KE, Saxerholt H, Midtvedt T. Development of five metabolic activities associated with the intestinal microflora of healthy infants. J Pediatr Gastroenterol Nutr 1988; 7: 559 - 67.
    • 11. Midtvedt A-C, Midtvedt T. Production of short chain fatty acids by the intestinal microflora during the first two years of human life. J Pediatr Gastroenterol Nutr 1992; 15: 395 - 403.
    • 12. Midtvedt A-C, Carlstedt-Duke B, Midtvedt T. Establishment of a mucin-degrading intestinal microflora during the first two years of human life. J Pediatr Gastroenterol Nutr 1994; 18: 321 - 6.
    • 13. Spiller GA, Chernoff MC, Hill RA, Gates JE, Nassar JJ, Shipley EA. Effect of purified cellulose pectin and a low residue diet of faecal volatile fatty acids, transit time and faecal weight in humans. Am J Clin Nutr 1980; 33: 754 - 9.
    • 14. Holdeman LV, Moore WEC, eds. In: Anaerobe Laboratory Manual, 2nd edn. Blacksburg, VA: Virginia Polytechnic Institute and State University, 1973.
    • 15. Gothfors L. Effects of diet on intestinal flora. Acta Paediatr Scand Suppl 1989; 351: 118 - 21.
    • 16. Livesey G. Energy values of unavailable carbohydrate and diets: an inquiry and analysis. Am J Clin Nutr 1990; 51: 617 - 37.
    • 17. Midtvedt A-C, Midtvedt T. Conversion of cholesterol to coprostanol by the intestinal microflora during the first two years of human life. J Pediatr Gastroenterol Nutr 1993; 17: 161 - 8.
    • 18. Mykka¨nen H, Tikka J, Pitka¨nen T, Ha¨nninen O. Fecal bacterial enzyme activities in infants increase with age and adoption of adult-type diet. J Pediatr Gastroenterol Nutr 1997; 25: 312 - 6.
    • 19. Gro¨ nlund M-M, Salminen S, Mykka¨nen H, Kero P, Lehtonen O-P. Development of intestinal bacterial enzymes in infants - relationship to mode of delivery and type of feeding. APMIS 1999; 107: 655 - 60.
    • 20. The Scottish Diet Report. Scottish Office. Home & Health Dept, Edinburgh: HMSO, 1993.
    • 21. Foster K, Lader D, Cheesebrough S. Infant Feeding 1995. Office for National Statistics, London: The Stationery Office, 1997.
  • No related research data.
  • No similar publications.

Share - Bookmark

Cite this article

Collected from