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fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
supplement, Complete (2013)
Publisher: Journal of Extracellular Vesicles
Journal: Journal of Extracellular Vesicles
Languages: English
Types: Article
Subjects:
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 1. Karlsson, et al. J Immunol Methods 1993;166:75 84. 1. Wood et al. Nat Biotechnol 2011. 2. Wood et al. Nat Protoc 2012.
    • The anaphylatoxin C5a, a potent complement activation product,
    • the cleavage of C5. Methods: Whole blood (anticoagulated with the
    • specific thrombin inhibitor lepirudin) from healthy donors (n=7),
    • exposed to 108 Nm/mL9eculizumab (Soliris†)100 mg/mL for 4 h
    • (378C) was sequentially centrifuged 2 times (2000 g,15 min, RT).
    • centrifugation 3 times (17000 g, 30 min, RT). Pelleted MPs were
    • blood exposed to 108 Nm/mL gave a significant shortening of
    • the time to clot formation: 303 s999 s (mean9SD) compared with
    • MPs isolated from unexposed blood: 1015 s9210 s (p=0.001).
    • the time to clot formation: 438 s9127 s (p=0.012) compared to
    • 1049 s9122 s, indicating an MP-associated TF-dependent clot
    • of eculizumab or bacteria alone. Conclusion: Inhibition of C5 reduced
  • No related research data.
  • Discovered through pilot similarity algorithms. Send us your feedback.

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