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Irvin, R. T.; Doig, P. C.; Sastry, P. A.; Heller, B.; Paranchych, W. (2011)
Publisher: Microbial Ecology in Health and Disease
Journal: Microbial Ecology in Health and Disease
Languages: English
Types: Article
Subjects:

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mesheuropmc: parasitic diseases
The adhesion of Pseudomonas aeruginosa strain O(PAO) to human buccal epithelial cells (BECs) was analysed by an equilibrium analysis of binding and the equilibrium parameters of adhesion determined. PA0 bound to a maximum of 159±28 receptor sites per BEC with an apparent association constant (Ka) of 2.89(±1.76) x 10-8 ml/CFU. As P. aeruginosa strain K(PAK) employs pili to adhere to BECs and there is substantial homology between the PAK pilin gene and the PAO pilin gene, the potential for competition for receptor sites on the BEC surface was investigated. PA0 and PAK competed for receptor sites in a reciprocal manner, although PA0 was ~ 10 fold more effective in competing for receptor sites than was PAK. Purified pili inhibited the adhesion of the heterologous strain, PA0 pili being ~ 10 fold more effective than PAK pili in this heterologous inhibition. The difference in effectiveness of PA0 and PA0 pili in competing with PAK and PAK pili for receptor sites reflected the difference in the Kas of the two strains.Keywords: Adhesion; Competition; Pili; Pseudomonas aeruginosa.

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