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Vasankari, Tommi J; Vasankari, Tuula M. (2006)
Publisher: Co-Action Publishing
Journal: Food & Nutrition Research
Languages: English
Types: Article
The prevalence of obesity is increasing worldwide. Increasing body weight together with decreasing physical activity is expected to increase the incidence of several diseases related to lifestyle, such as adult type diabetes and vascular atherosclerotic diseases. It has been postulated that increasing consumption of fructose may be a contributory factor in the development of obesity and the accompanying metabolic abnormalities. Most studies supporting these hypotheses, however, are animal studies, which suggest that consumption of high amounts of fructose may stimulate lipogenesis and thus alter lipid metabolism and increase body weight. This review explores the effects of dietary fructose on lipid metabolism in humans, with the conclusion that the data so far do not support any significant specific adverse effect of fructose apart from its energy content. A small amount of fructose may even improve glucose tolerance, and studies to date on diabetic subjects indic ate that isocaloric replacement of some glucose-based carbohydrates with fructose may improve metabolic control. Keywords: cholesterol; diabetes; fructose; oral glucose tolerance; triglycerides
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    • 1. Uusitupa MI. Fructose in the diabetic diet. Am J Clin Nutr 1994; 59: 753 7S.
    • 2. Elliott SS, Keim NL, Stern JS, Teff K, Havel PJ. Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 2002; 76: 911 22.
    • 3. Havel PJ. Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism. Nutr Rev 2005; 63: 133 57.
    • 4. Riby JE, Fujisawa T, Kretchmar N. Fructose absorption. Am J Clin Nutr 1993; 58: 748 53S.
    • 5. Frayn KN, Kingman SM. Dietary sugars and lipid metabolism in humans. Am J Clin Nutr 1995; 62: 250 61S.
    • 6. Crapo PA, Kolterman OG. The metabolic effects of 2- week fructose feeding in normal subjects. Am J Clin Nutr 1984; 39: 525 34.
    • 7. Bossetti BM, Kocher LM, Moranz JF, Falko JM. The effects of physiologic amounts of simple sugars on lipoprotein, glucose and insulin levels in normal subjects. Diabetes Care 1984; 7: 309 12.
    • 8. Reiser S, Powell AS, Scholfield DJ, Panda P, Ellwood KC, Canary JJ. Blood lipids, lipoproteins, apolipoproteins, and uric acid in men fed diets containing fructose or high-amylose cornstarch. Am J Clin Nutr 1989; 49: 832 9.
    • 9. Swanson JE, Laine DC, Thomas W, Bantle JP. Metabolic effects of dietary fructose in healthy subjects. Am J Clin Nutr 1992; 55: 851 6.
    • 10. Bantle JP, Raatz SK, Thomas W, Georgopoulos A. Effects of dietary fructose on plasma lipids in healthy subjects. Am J Clin Nutr 2000; 72: 1128 34.
    • 11. Jeppesen J, Chen YI, Zhou MY, Schaaf P, Coulston A, Raeven GM. Postprandial triglyceride and retinyl ester responses to oral fat: effects of fructose. Am J Clin Nutr 1995; 61: 787 91.
    • 12. Cohen JC, Schall R. Reassessing the effects of simple carbohydrates on the serum triglyceride responses to fat meals. Am J Clin Nutr 1988; 48: 1031 4.
    • 13. Teff KL, Elliott SS, Tschop M, Kieffer TJ, Rader D, Heiman M, et al. Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab 2004; 89: 2963 72.
    • 14. Anderson JW, Story LJ, Zettwoch NC, Gustafson NJ, Jefferson BS. Metabolic effects of fructose supplementation in diabetic individuals. Diabetes Care 1989; 12: 337 44.
    • 15. Thorburn AW, Crapo PA, Beltz WF, Wallace P, Witztum JL, Henry RR. Lipid metabolism in non-insulin-dependent diabetes: effects of long-term treatment with fructose-supplemented mixed meals. Am J Clin Nutr 1989; 50: 1015 22.
    • 16. Malerbi DA, Paiva ESA, Duarte AN, Wajchenberg BL. Metabolic effects of dietary sucrose and fructose in type II diabetic subjects. Diabetes Care 1996; 19: 1249 56.
    • 17. Hallfrisch J, Reiser S, Prather ES. Blood lipids distribution of hyperinsulinemic men consuming three levels of fructose. Am J Clin Nutr 1983; 37: 740 8.
    • 18. Osei K, Bossetti B. Dietary fructose as a natural sweetener in poorly controlled type 2 diabetes: a 12- month crossover study of effects on glucose, lipoprotein and apolipoprotein metabolism. Diabet Med 1989; 6: 506 11.
    • 19. Osei K, Falko J, Bossetti BM, Holland GC. Metabolic effects of fructose as a natural sweetener in the physiologic meals of ambulatory obese patients with type II diabetes. Am J Med 1987; 83: 249 55.
    • 20. Reiser S, Bohn E, Hallfrisch J, Michaelis OE, Keeney M, Prather ES, et al. Serum insulin and glucose in hyperinsulinemic subjects fed three different levels of sucrose. Am J Clin Nutr 1981; 34: 2348 58.
    • 21. Crapo PA, Kolterman OG, Henry RR. Metabolic consequences of two-week fructose feeding in diabetic subjects. Diabetes Care 1986; 9: 111 9.
    • 22. Bantle JP, Swanson JE, Thomas W, Laine DC. Metabolic effects of dietary fructose in diabetic subjects. Diabetes Care 1992; 15: 1468 76.
    • 23. Koivisto VA, Yki-Jarvinen H. Fructose and insulin sensitivity in patient with type 2 diabetes. J Intern Med 1993; 233: 145 53.
    • 24. Abraha A, Humphreys SM, Clark ML, Matthews DR, Frayn KN. Acute effect of fructose on postprandial lipaemia in diabetic and non-diabetic subjects. Br J Nutr 1998; 80: 169 75.
    • 25. Robinson D, Bevan EA, Hinohara S, Takahashi T. Seasonal variation in serum cholesterol levels: evidence from UK and Japan. Atherosclerosis 1992; 95: 15 24.
    • 26. Kanarek RB, Orthen-Gambill N. Differential effects of sucrose, fructose and glucose on carbohydrate-induced obesity in rats. J Nutr 1982; 112: 1546 54.
    • 27. Kasim-Karakas SE, Vriend H, Almario R, Chow LC, Goodman MN. Effects of dietary carbohydrates on glucose and lipid metabolism in golden Syrian hamsters. J Lab Clin Med 1996; 128: 208 13.
    • 28. Suga A, Hirano T, Kageyama H, Osaka T, Namba Y, Tsuji M, et al. Effects of fructose and glucose on plasma leptin, insulin, and insulin resistance in lean and VMHlesioned obese rats. Am J Physiol Endocrinol Metab 2000; 278: E677 83.
    • 29. Schulze MB, Manson JE, Ludwig DS. Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women. JAMA 2004; 292: 927 34.
    • 30. Moore MC, Cherrington AD, Mann SL, Davis SN. Acute fructose administration decreases the glycemic response to an oral glucose tolerance test in normal adults. J Clin Endocrinol Metab 2000; 85: 4515 9.
    • 31. Moore MC, Mann SL, Davis SN, Cherrington AD. Acute fructose administration improves oral glucose tolerance in adults with type 2 diabetes. Diabetes Care 2001; 24: 1882 7.
    • 32. Heacock PM, Hertzler SR, Wolf BW. Fructose prefeeding reduces the glycemic response to a high-glycemic index, starchy food in humans. J Nutr 2002; 132: 2601 4.
    • 33. Gannon MC, Nuttall FQ, Grant CT, Ercan-Fang S, Ercan-Fang N. Stimulation of insulin secretion by fructose ingested with protein in people with untreated type 2 diabetes. Diabetes Care 1998; 21: 16 22.
    • 34. McGuinness OP, Cherrington AD. Effects of fructose on hepatic glucose metabolism. Curr Opin Clin Nutr Metab Care 2003; 6: 441 8.
    • 35. Truswell AS, Seach JM, Thorburn AW. Incomplete absorption of pure fructose in healthy subjects and the facilitating effects of glucose. Am J Clin Nutr 1998; 48: 1424 30.
    • 36. Shiota M, Moore MC, Galassetti P, Monohan M, Neal DW, Shulman GI, Cherrington AD. Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dogs. Diabetes 2002; 51: 469 78.
    • 37. Shiota M, Galassetti P, Monohan M, Neal DW, Cherrington AD. Small amounts of fructose markedly augment hepatic glucose uptake in the conscious dogs. Diabetes 1998; 47: 867 73.
    • 38. Bantle JP, Laine DC, Thomas JW. Metabolic effects of dietary fructose and sucrose in types I and II diabetic subjects. JAMA 1986; 256: 3241 6.
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