Remember Me
Or use your Academic/Social account:


Or use your Academic/Social account:


You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.


Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message


Verify Password:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Deckelbaum, Richard J.; Chang, Chuchun; Worgall, Tilla S.; Seo, Toru (2006)
Publisher: Co-Action Publishing
Journal: Food & Nutrition Research
Languages: English
Types: Article
Accumulating evidence in both humans and animal models clearly indicates that a group of very long-chain polyunsaturated fatty acids, the n-3 (or omega-3) fatty acids, have distinct and important bioactive properties compared with other groups of fatty acids. The n-3 fatty acids are known to reduce many risk factors associated with several diseases, such as cardiovascular diseases, diabetes and cancer. The mechanisms whereby n-3 fatty acids affect gene expression are complex. As examples, n-3 fatty acids regulate two groups of transcription factors, sterol regulatory element binding proteins and peroxisome proliferator activated receptors, which are critical for modulating the expression of genes controlling both systemic and tissuespecific lipid homeostasis. Modulation of specific genes by n-3 fatty acids and cross-talk between these genes are responsible for many effects of n-3 fatty acids. Keywords: atherosclerosis; gene expression; n-3 fatty acids; SREBP
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 1. Seo T, Blaner WS, Deckelbaum RJ. Omega-3 fatty acids: molecular approaches to optimal biological outcomes. Curr Opin Lipidol 2005; 16: 11 8.
    • 2. Deckelbaum RJ, Worgall TS, Seo T. n-3 Fatty acids and gene expression. Am J Clin Nutr 2006; 83(Suppl): 1520 5S.
    • 3. Rumsey SC, Galeano NF, Lipschitz B, Deckelbaum RJ. Oleate and other long chain fatty acids stimulate low density lipoprotein receptor activity by enhancing acyl coenzyme A: cholesterol acyl transferase activity and altering intracellular regulatory cholesterol pools in cultured cells. J Biol Chem 1995; 270: 10008 16.
    • 4. Seo T, Oelkers PM, Giattina MR, Worgall TS, Sturley SL, Deckelbaum RJ, et al. Differential modulation of ACAT1 and ACAT2 transcription and activity by long chain free fatty acids in cultured cells. Biochemistry 2001; 40: 4756 62.
    • 5. Horton JD, Shah NA, Warrington JA, Anderson NN, Park SW, Brown MS, Goldstein JL. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc Natl Acad Sci USA 2003; 100: 12027 32.
    • 6. Worgall TS, Sturley SL, Seo T, Osborne TF, Deckelbaum RJ. Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory elementbinding protein. J Biol Chem 1998; 273: 25537 40.
    • 7. Thewke DP, Panini SR, Sinensky M. Oleate potentiates oxysterol inhibition of transcription from sterol regulatory element-1-regulated promoters and maturation of sterol regulatory element-binding proteins. J Biol Chem 1998; 273: 21402 7.
    • 8. Hannah VC, Ou J, Luong A, Goldstein JL, Brown MS. Unsaturated fatty acids down-regulate SREBP isoforms 1a and 1c by two mechanisms in HEK-293 cells. J Biol Chem 2001; 276: 4365 72.
    • 9. Xu J, Cho H, O'Malley S, Park JH, Clarke SD. Dietary polyunsaturated fats regulate rat liver sterol regulatory element binding proteins-1 and -2 in three distinct stages and by different mechanisms. J Nutr 2002; 132: 3333 9.
    • 10. Johnson RA, Hamilton JA, Worgall TS, Deckelbaum RJ. Free fatty acids modulate intermembrane trafficking of cholesterol by increasing lipid mobilities: novel 13C NMR analyses of free cholesterol positioning. Biochemistry 2003; 42: 1637 45.
    • 11. Worgall TS, Johnson RA, Seo T, Gierens H, Deckelbaum RJ. Unsaturated fatty acid-mediated decreases in sterol regulatory element-mediated gene transcription are linked to cellular sphingolipid metabolism. J Biol Chem 2002; 277: 3878 85.
    • 12. Worgall TS, Juliano RA, Seo T, Deckelbaum RJ. Ceramide synthesis correlates with the posttranscriptional regulation of the sterol-regulatory element-binding protein. Arterioscler Thromb Vasc Biol 2004; 24: 943 8.
    • 13. Jump DB. Dietary polyunsaturated fatty acids and regulation of gene transcription. Curr Opin Lipidol 2002; 13: 155 64.
    • 14. Clarke SD. The multi-dimensional regulation of gene expression by fatty acids: polyunsaturated fats as nutrient sensors. Curr Opin Lipidol 2004; 15: 13 8.
    • 15. Seo T, Qi K, Chang C, Liu Y, Worgall TS, Ramakrishnan R, Deckelbaum RJ. Saturated fat-rich diet enhances selective uptake of LDL cholesteryl esters in the arterial wall. J Clin Invest 2005; 115: 2214 22.
    • 16. Merkel M, Kako Y, Radner H, Cho IS, Ramasamy R, Brunzell JD, et al. Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases very low density lipoprotein uptake: direct evidence that lipoprotein lipase bridging occurs in vivo. Proc Natl Acad Sci USA 1998; 95: 13841 6.
  • No related research data.
  • No similar publications.

Share - Bookmark

Funded by projects

  • NIH | Selective Uptake from LDL:R...

Cite this article

Collected from