Remember Me
Or use your Academic/Social account:


Or use your Academic/Social account:


You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.


Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message


Verify Password:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Orrhage, K.; Brismar, B.; Nord, C. E. (2011)
Publisher: Microbial Ecology in Health and Disease
Journal: Microbial Ecology in Health and Disease
Languages: English
Types: Article

Classified by OpenAIRE into

mesheuropmc: food and beverages, fluids and secretions, digestive system
Thirty healthy volunteers in three groups participated in a study of the influence of supplements containing Bifidobacterium longum and Lactobacillus acidophilus on the intestinal microbiota during administration of clindamycin. All groups received clindamycin perorally q.d.s. for 7d. Group I also received a supplement with B. longum and L. acidophilus, group II received a supplement with B. longum and group III received a placebo, for 21 d. The numbers of anaerobic microorganisms decreased in all groups, but the reduction of bacteroides was significantly smaller in group I than in group III (P<0.05). No subject in group III had any intestinal bifidobacteria on day 7. Significant decreases of volatile fatty acids in faecal specimens were seen (P<0.05). There was a smaller incidence of gastrointestinal discomfort in group I than in group III (P<0.05).Keywords - Bifidobacterium longum, Lactobacillus acidophilus, Probiotics, Clindamycin, Supplementation, Intestinal microbiota (microflora), Volatile fatty acids.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 1. Aronsson B, Mollby R, Nord CE.(1981). Occurrence of toxin producing Clostridium dificile in antibiotic associated diarrhea in Sweden. Medical Microbiology and Immunology 110,27-35.
    • 2. Aronsson B, Mollby R, Nord CE. (1985). Antimicrobial agents and Clostridium dificile in acute enteric disease: epidemiological data from Sweden 1980-1982. Journal of Infectious Diseases 151, 476-48 I .
    • 3 . Beerens H. (1990).An electiveand selectiveisolation medium for Bijidobacterium spp. Letters in Applied Microbiology 11, 155-157.
    • 4. Biasco G, Paganelli GM. Brandi G , Brillanti S, Lami F, Callegari C, Gizzi G. (1991). Effect of Lactobacillus acidophilusand Bijidobacterium bifidum on rectal cell kinetics and fecal pH. Italian Journalof Gastroenterology 23, 142.
    • 5. Black F, Einarsson K, Lidbeck A, Orrhage K, Nord CE. (1991). Effect of lactic acid producing bacteria on the human intestinal microflora during ampicillin treatment. Scandinavian Journal of Infectious Diseases 23,2417254.
    • 6. Borthen L, Heimdahl A, Lindqvist L, Nord CE. (1983). Determination of volatile fatty acids in saliva and faeces by gas-liquid chromatography: a rapid method for detection of antibiotic-induced changes in the oropharyngeal and gastrointestinal microflora. International Journal o f Microbiology 1, 3 5 4 5 .
    • 7. Colombel JF, Cortot A, Neut C, Romond C. (1987).Yoghurt with Bijidobacterium longum reduces erythromycin-inducedgastrointestinaleffects. Lancet ii, 43.
    • 8 . Erlich M, van Tassel RL, Libby JM, Wilkins TD. (1980). Production of Clostridium dijicile antitoxin. Infection and Immunity 28, 1041-1043.
    • 9. George WL, Rolfe RD, Finegold SM. (1982). Clostridium difJicile and its cytotoxin in feces of patients with antimicrobial agent-associated diarrhea and miscellaneous conditions. Journal o f Clinical Microbiology 15, 1049-1053.
    • 10. George WL, Sutter VL, Citron D, Finegold SM. (1976). Selective and differential medium for isolation of Clostridium di9cile. Journul of Clinical Microbiology 9 , 2 14-2 19.
    • 11. Gorbach SL, Chang TW, Goldin B. (1987). Successful treatment of relapsing Clostridium tlifji'cile colitis with Lactobacillus GG. Lancet ii, 1519 (letter).
    • 12. Goldin BR, Swenson L, Dwyer J , Sexton M . Gorbach SL. (1980). Effect of diet and Lactobacillus acidophilus supplements o n human fecal bacterial enzymes. Journal of National Cancer Instituti. 64, 255-261.
    • 13. Golledge CL, McKenzie T, Riley T. (1989). Extended spectrum cephalosporins and Clostritlium difficile. Journal o jAntimicrobial Chemotherapy 23, 929-93 1.
    • 14. Gotz VP, Romankiewics JA, Moss J, Murray HW. (1979). Prophylaxis against ampicillin-induced diarrhoea with a lactobacilluspreparation. Anierictrn Journal of Hospital Pharmacology 36,754757.
    • 15. Hartley MG, Hudson MJ, Swarbrick ET, Hill M J , Gent AE, Hellier MD, Grace RH. (1992). The rectal mucosa-associated microflora in patients with ulcerative colitis. Journal of Medical Microhiologj, 36,96103.
    • 16. Heimdahl A, Nord CE. (1979). Effect of phenoxymethylpenicillin and clindamycin on the oral, throat and faecal microflora of man. Scandinavian Journal of Infectious Diseases 11,233-242.
    • 17. Heimdahl A, Nord CE. (1985). Colonization of the oropharynx with pathogenic microorganisms: a potential risk factor for infection in compromised patients. Chemoterapiu 4, 1 8 6191.
    • 18. Hotta M, Sato Y, Iwata S. Yamashita N , Sunakawa K, Oikawa T, Tanaka R, Watanabe K, Takayama H, Yaima M , Sekiguchi S, Arai S, Sakurai T, Mutai M. (1987). Clinical effects o f B$dobacterium preparations on pediatric intractable diarrhea. Keio Journal of Medicine 36,298-3 14.
    • 19. Hmerstad T, Carlstedt-Duke B. Lingaas E, Midtvedt T, Norin E, Saxerholt H, Steinbakk M. (1986). Influence of ampicillin, clindamycin, and metronidazole on faecal excretion of short-chain fatty acids in healthy subjects. Scandinavian Journnl of' Gastroenterology 21,621-626.
    • 20. Kotz C, Peterson L, Moody J, Savaiano D, Levitt M. (1992). Effect of yoghurt on clindamycininduced Clostridiiim dijicile colitis in hamsters. Digestive Diseases and Sciences 37, 129-1 32.
    • 21. Lidbeck A, Edlund C, Gustafsson J-A, Kager L, Nord CE. (1 988).Impact of Lactobacillusaciriopliilus on thc normal intestinal microflora after administration of two antimicrobial agents. Infection 16, 329-3 36.
    • 22. Lidbeck A, Gustafsson J-A, Nord CE. (1987). Impact of Lactobacillus acidophilus supplements o n the human oropharyngeal and intestinal microflora. Scandinavian Journul qf Infectious Diseases 19, 531-537.
    • 23. Lidbeck A. Nord CE. (1991). Lactobacilli in relation to human ecology and antimicrobial therapy. Internutional Journal of Tissuc Reacfions 13, I 15-122.
    • 24. Marsh WW, Hentges DJ, Chavarria JF, Thal WR, Adams M K , Achi R, Mata L. (1990). Influence of orally administered antibiotics on faecal p H and volatile fatty acid concentrations of infants and young children. Microbial Ecology in Health and Disease 3, 7-1 3.
    • 25. Marteau P, Pochart P, Flourie B, Pellier P, Santos L, Desjeux J-F, Rambaud J-C. (1990). Effect ofchronic ingestion of a fermented dairy product containing Luctobucillus ncidophilus and B~jidobucterium biJidumon metabolic activities of the colonic flora in humans. American Journal of' Clinical Nutrition 52, 685-688.
    • 26. Nord CE, Edlund C. (1991). Ecological effects of antimicrobial agents on the human intestinal microflora. Microhiul Ecology in Henlth and Diseuse 4,193-207.
    • 27. Nord CE, Heimdahl A. Kager L. (1986). Antimicrobial induced alterations of the human oropharyngeal and intestinal microflora. Scrmdinaviun Journal of Infectious Diseases Supplement 4 9 , 6 4 7 2 .
    • 28. Nord CE, Heimdahl A, Kager L, Malmborg AS. (1984). The impact of different antimicrobial agents o n the normal gastrointestinal microflora of humans. re vie^:^ of Injeciious Diseases 6,27&275.
    • 29. Orrhage K , Lidbeck A, Nord CE. (1991). Effect of B~jidobactrriuniloiigiim supplements on the human faecal microflora. Microhiul Ecology in Health und D ~ S ~ U4,S26C5-210.
    • 30. Peltonen R, Eerola E. (1992). Direct automatic bacterial analysis oC rat stool samplcs; the effects of diet and medical treatment studied by computerised gas-liquid chromatography of bacterial fatty acids. Microbiul Ecology in Health and Disease 593-103.
    • 31. Rolfe R . (1984). Role of volatile fatty acids in colonization resistance to Clostridium d$hcilc.. Infiction and Immunity 45, 185-19 1,
    • 32. Rolfe R, Hclebian S, Finegold S. (1981). Bacterial interference between Clostridium difficile and normal fecal flora. Journal of' Infectious Diseases 143, 4 7 W 7 5 .
    • 33. Teraguchi S, Uehara M, Ogasa K, Mitsuoka T. (1978). Enumeration of bifidobacteria in dairy products. J U ~ U I I P SJoPuvnnl Qf Bacterio1og.j. 33, 753-761. (Cited in Dairy Science Abstracts (1980) 42,253-254.)
    • 34. Zoppi G, Deganello A, Benoni G, Saccomani F. ( I 982). Oral bacteriotherapy in clinical practice. European Journcil of'Pediatrics 139, 18-2 I .
  • No related research data.
  • No similar publications.

Share - Bookmark

Cite this article

Collected from