LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Risérus, Ulf (2006)
Publisher: Co-Action Publishing
Journal: Food & Nutrition Research
Languages: English
Types: Article
Subjects:
Trans fatty acids (TFA) could affect cell membrane functions, and may therefore influence peripheral insulin sensitivity and the risk of developing type 2 diabetes. It is important to understand whether low amounts of TFA consumed during long periods may promote insulin resistance and have clinically relevant effects on diabetes risk. Data from controlled intervention studies examining the effects of TFA on insulin sensitivity and type 2 diabetes are reviewed. The results show no consistent effect of TFA on insulin sensitivity in lean healthy subjects, but there is some evidence that TFA could impair insulin sensitivity more than unsaturated fat in subjects with insulin resistance or type 2 diabetes. In particular, conjugated TFA, i.e. certain isomers of conjugated linoleic acid (CLA), impair insulin sensitivity and could promote metabolic disorders. The effect of CLA (trans10cis12) on insulin sensitivity and lipid peroxidation is the most dramatic adverse effect described for a dietary fatty acid. CLA isomers are found in relatively low amounts, but long-term exposure may, in theory, have unwanted health effects. The mechanisms of CLA effects are still not completely understood, but may involve increased oxidative stress and inflammation, as well as endothelial dysfunction and direct down-regulating effects on transcription factors required for optimal insulin sensitivity. The inconsistent effect of TFA as a group may be due to methodological limitations (e.g. few studies, with short duration and small sample size) and differences between studies in design, and the type and amount of TFA used. Large controlled trials have been required to demonstrate adverse effects of saturated fat on insulin sensitivity, and similar efforts will be needed to clarify the effect of TFA on insulin sensitivity and diabetes risk. CLA isomers are a group of TFA with potentially adverse effects on glucose metabolism. There are no data to suggest that TFA in general impair insulin sensitivity in practice, compared with such an effect of the much more abundant saturated fatty acids. Keywords: CLA; controlled trial; inflammation; insulin resistance; insulin sensitivity; oxidative stress; trans fatty acids
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 1. Salmeron J, Hu FB, Manson JE, Stampfer MJ, Colditz GA, Rimm EB, et al. Dietary fat intake and risk of type 2 diabetes in women. Am J Clin Nutr 2001; 73: 1019 26.
    • 2. Vessby B, Unsitupa M, Hermansen K, Riccardi G, Rivellese AA, Tapsell LC, et al. KANWU Study. Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: the KANWU Study. Diabetologia 2001; 44: 312 9.
    • 3. Saravanan N, Haseeb A, Ehtesham NZ, Ghafoorunissa SA. Differential effects of dietary saturated and trans - fatty acids on expression of genes associated with insulin sensitivity in rat adipose tissue. Eur J Endocrinol 2005; 153: 159 65.
    • 4. Louheranta AM, Turpeinen AK, Vidgren HM, Schwab US, Uusitupa MI. A high-trans fatty acid diet and insulin sensitivity in young healthy women. Metabolism 1999; 48: 870 5.
    • 5. Lovejoy JC, Smith SR, Champagne CM, Most MM, Lefevre M, DeLany JP, et al. Effects of diets enriched in saturated (palmitic), monounsaturated (oleic), or trans (elaidic) fatty acids on insulin sensitivity and substrate oxidation in healthy adults. Diabetes Care 2002; 25: 1283 8.
    • 6. Lichtenstein AH, Erkkila AT, Lamarche B, Schwab US, Jalbert SM, Ausman LM. Influence of hydrogenated fat and butter on CVD risk factors: remnant-like particles, glucose and insulin, blood pressure and C-reactive protein. Atherosclerosis 2003; 171: 97 107.
    • 7. Christiansen E, Schnider S, Palmvig B, Tauber-Lassen E, Pedersen O. Intake of a diet high in trans monounsaturated fatty acids or saturated fatty acids. Effects on postprandial insulinemia and glycemia in obese patients with NIDDM. Diabetes Care 1997; 20: 881 7.
    • 8. Jung MY, Ha YL. Conjugated linoleic acid isomers in partially hydrogenated soybean oil obtained during nonselective and selective hydrogenation processes. J Agric Food Chem 1999; 47: 704 8.
    • 9. Rise´rus U, Arner P, Brismar K, Vessby B. Treatment with dietary trans 10cis 12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care 2002; 25: 1516 21.
    • 10. Rise´rus U, Jovinge S, Basu S, Nordin Fredrikson G, .A¨ rnlo¨v J, Vessby B. Supplementation with conjugated linoleic acid causes isomer-dependent oxidative stress and elevated C-reactive protein: a potential link to fatty acid induced insulin resistance. Circulation 2002; 106: 1925 9.
    • 11. Rise´rus U, Vessby B, .A¨ rnlo¨v J, Basu S. Effects of cis 9trans 11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation and proinflammatory markers in obese men. Am J Clin Nutr 2004; 80: 279 83.
    • 12. Moloney F, Yeow TP, Mullen A, Nolan JJ, Roche HM. Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus. Am J Clin Nutr 2004; 80: 887 95.
    • 13. Poirier H, Shapiro JS, Kim RJ, Lazar MA. Nutritional supplementation with trans -10,cis -12-conjugated linoleic acid induces inflammation of white adipose tissue. Diabetes 2006; 55: 1634 41.
    • 14. Taylor JS, Williams SR, Rhys R, James P, Frenneaux MP. Conjugated linoleic acid impairs endothelial function. Arterioscler Thromb Vasc Biol 2006; 26: 307 12.
    • 15. Granlund L, Juvet LK, Pedersen JI, Nebb HI. Trans 10,- cis 12-conjugated linoleic acid prevents triacylglycerol accumulation in adipocytes by acting as a PPARg modulator. J Lipid Res 003;44:1441 52.
    • 16. Tsuboyama-Kasaoka N, Takahashi M, Tanemura K, Kim HJ, Tange T, Okuyama H, et al. Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes 2000; 49: 1534 42.
  • No related research data.
  • No similar publications.

Share - Bookmark

Cite this article

Collected from