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Aamir Khakwani; Anna L Rich; Laila J Tata; Helen A Powell; Rosamund A Stanley; David R Baldwin; Richard B Hubbard
Publisher: Public Library of Science (PLoS)
Journal: PLoS ONE
Languages: English
Types: Article
Subjects: Cancer Treatment, Research Article, Medicine, Oncology, Pharmacoepidemiology, Epidemiology, Q, Chemotherapy and Drug Treatment, R, Drugs and Devices, Cancer Epidemiology, Lung and Intrathoracic Tumors, Science, Radiotherapy, Cancers and Neoplasms, Small Cell Lung Cancer
Background: The purpose of this study was to identify trends in survival and chemotherapy use for individuals with smallcell lung cancer (SCLC) in England using the National Lung Cancer Audit (NLCA).\ud Methods: We used data from the NLCA database to identify people with histologically proven SCLC from 2004–2011. We\ud calculated the median survival by stage and assessed whether patient characteristics changed over time. We also assessed whether the proportion of patients with records of chemotherapy and/or radiotherapy changed over time.\ud Results: 18,513 patients were diagnosed with SCLC in our cohort. The median survival was 6 months for all patients, 1 year for those with limited stage and 4 months for extensive stage. 69% received chemotherapy and this proportion changed very slightly over time (test for trends p = 0.055). Age and performance status of patients remained stable over the study period, but the proportion of patients staged increased (p-value,0.001), mainly because of improved data completeness. There has been an increase in the proportion of patients that had a record of receiving both chemotherapy and radiotherapy each year (from 19% to 40% in limited and from 9% to 21% in extensive stage from 2004 to 2011). Patients who received chemotherapy with radiotherapy had better survival compared with any other treatment (HR 0.24, 95% CI 0.23–0.25).\ud Conclusion: Since 2004, when the NLCA was established, the proportion of patients with SCLC having chemotherapy has remained static. We have found an upward trend in the proportion of patients receiving both chemotherapy and radiotherapy which corresponded to a better survival in this group, but as it only applied for a small proportion of patients, it was not enough to change the overall survival.

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