Remember Me
Or use your Academic/Social account:


Or use your Academic/Social account:


You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.


Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message


Verify Password:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Aengevaeren, Vincent L.; Hopman, Maria T.E.; Thijssen, Dick H.J.; van Kimmenade, Roland R.; de Boer, Menko-Jan; Eijsvogels, Thijs M.H. (2017)
Publisher: Elsevier BV
Journal: International Journal of Cardiology
Languages: English
Types: Article
Subjects: RC1200, Cardiology and Cardiovascular Medicine

Classified by OpenAIRE into

mesheuropmc: cardiovascular diseases, human activities, hormones, hormone substitutes, and hormone antagonists
BACKGROUND: Healthy athletes demonstrated increased B-type natriuretic peptide (BNP) concentrations following exercise, but it is unknown whether these responses are exaggerated in individuals with cardiovascular risk factors (CVRF) or disease (CVD). We compared exercise-induced increases in BNP between healthy controls (CON) and individuals with CVRF or CVD. Furthermore, we aimed to identify predictors for BNP responses. METHODS: Serum BNP concentrations were measured in 191 participants (60+/-12yrs) of the Nijmegen Marches before (baseline) and immediately after 4 consecutive days of walking exercise (30-50km/day). CVRF (n=54) was defined as hypertension, hypercholesterolemia, obesity or smoking and CVD (n=55) was defined as a history of myocardial infarction, heart failure, atrial fibrillation or angina pectoris. RESULTS: Individuals walked 487+/-79min/day at 65+/-10% of their maximum heart rate. Baseline BNP concentrations were higher for CVD (median: 28.1pg/ml; interquartile range: 13-50, p<0.001) compared to CVRF (3.9pg/ml; 0-14) and CON (5.5pg/ml; 0-14). Post-exercise BNP concentrations were elevated in CVD (35.7pg/ml, 17-67, p=0.01), but not in CVRF participants (p=0.11) or CON (p=0.07). No cumulative effect in BNP concentrations was observed across the consecutive walking days (p>0.05). Predictors for post-exercise BNP (R2=0.77) were baseline BNP, beta-blocker use and age. CONCLUSION: Prolonged moderate-intensity walking exercise increases BNP concentrations in CVD participants, but not in CVRF and CON. BNP increases were small, and did not accumulate across consecutive days of exercise. These findings suggest that prolonged walking exercise for multiple consecutive days is feasible with minimal effect on myocardial stretch, even for participants with CVD.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • [1] E. Braunwald, Biomarkers in heart failure, N. Engl. J. Med. 358 (2008) 2148-2159.
    • [2] P. Ponikowski, A.A. Voors, S.D. Anker, H. Bueno, J.G. Cleland, A.J. Coats, et al., 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC, Eur. J. Heart Fail. 18 (2016) 891-975.
    • [3] H.K. Win, S.M. Chang, M. Raizner, G. Shah, F. Al Basky, U. Desai, et al., Percent change in B-type natriuretic peptide levels during treadmill exercise as a screening test for exercise-induced myocardial ischemia, Am. Heart J. 150 (2005) 695-700.
    • [4] M. Maeder, T. Wolber, H. Rickli, J. Myers, D. Hack, W. Riesen, et al., B-type natriuretic peptide kinetics and cardiopulmonary exercise testing in heart failure, Int. J. Cardiol. 120 (2007) 391-398.
    • [5] R.S. Foote, J.D. Pearlman, A.H. Siegel, K.T. Yeo, Detection of exercise-induced ischemia by changes in B-type natriuretic peptides, J. Am. Coll. Cardiol. 44 (2004) 1980-1987.
    • [6] M.S. Sabatine, D.A. Morrow, J.A. de Lemos, T. Omland, M.Y. Desai, M. Tanasijevic, et al., Acute changes in circulating natriuretic peptide levels in relation to myocardial ischemia, J. Am. Coll. Cardiol. 44 (2004) 1988-1995.
    • [7] S. Bergeron, J.E. Moller, K.R. Bailey, H.H. Chen, J.C. Burnett, P.A. Pellikka, Exertional changes in circulating cardiac natriuretic peptides in patients with suggested coronary artery disease, J. Am. Soc. Echocardiogr. 19 (2006) 772-776.
    • [8] M.T. Maeder, D. Staub, Y. Surnier, T. Reichlin, M. Noveanu, T. Breidthardt, et al., Determinants of absolute and relative exercise-induced changes in B-type natriuretic peptides, Int. J. Cardiol. 147 (2011) 409-415.
    • [9] P.Y. Marie, P.M. Mertes, N. Hassan-Sebbag, N. de Talence, K. Djaballah, W. Djaballah, et al., Exercise release of cardiac natriuretic peptides is markedly enhanced when patients with coronary artery disease are treated medically by beta-blockers, J. Am. Coll. Cardiol. 43 (2004) 353-359.
    • [10] M. Tanaka, Y. Ishizaka, Y. Ishiyama, J. Kato, O. Kida, K. Kitamura, et al., Exerciseinduced secretion of brain natriuretic peptide in essential hypertension and normal subjects, Hypertens. Res. 18 (1995) 159-166.
    • [11] M. Kohno, K. Yasunari, K. Yokokawa, T. Horio, H. Kano, M. Minami, et al., Plasma brain natriuretic peptide during ergometric exercise in hypertensive patients with left ventricular hypertrophy, Metabolism 45 (1996) 1326-1329.
    • [12] W.S. Huang, M.S. Lee, H.W. Perng, S.P. Yang, S.W. Kuo, H.D. Chang, Circulating brain natriuretic peptide values in healthy men before and after exercise, Metabolism 51 (2002) 1423-1426.
    • [13] J. Scharhag, K. George, R. Shave, A. Urhausen, W. Kindermann, Exercise-associated increases in cardiac biomarkers, Med. Sci. Sports Exerc. 40 (2008) 1408-1415.
    • [14] F. Sedaghat-Hamedani, E. Kayvanpour, L. Frankenstein, D. Mereles, A. Amr, S. Buss, et al., Biomarker changes after strenuous exercise can mimic pulmonary embolism and cardiac injury - a metaanalysis of 45 studies, Clin. Chem. 61 (2015) 1246-1255.
    • [15] D. Konig, Y.O. Schumacher, L. Heinrich, A. Schmid, A. Berg, H.H. Dickhuth, Myocardial stress after competitive exercise in professional road cyclists, Med. Sci. Sports Exerc. 35 (2003) 1679-1683.
    • [16] M.P. Leers, R. Schepers, R. Baumgarten, Effects of a long-distance run on cardiac markers in healthy athletes, Clin. Chem. Lab. Med. 44 (2006) 999-1003.
    • [17] H. Ohba, H. Takada, H. Musha, J. Nagashima, N. Mori, T. Awaya, et al., Effects of prolonged strenuous exercise on plasma levels of atrial natriuretic peptide and brain natriuretic peptide in healthy men, Am. Heart J. 141 (2001) 751-758.
    • [18] A. La Gerche, W.J. Inder, T.J. Roberts, M.J. Brosnan, H. Heidbuchel, D.L. Prior, Relationship between inflammatory cytokines and indices of cardiac dysfunction following intense endurance exercise, PLoS One 10 (2015), e0130031.
    • [19] A. La Gerche, K.A. Connelly, D.J. Mooney, A.I. MacIsaac, D.L. Prior, Biochemical and functional abnormalities of left and right ventricular function after ultraendurance exercise, Heart 94 (2008) 860-866.
    • [20] W. Frassl, R. Kowoll, N. Katz, M. Speth, A. Stangl, L. Brechtel, et al., Cardiac markers (BNP, NT-pro-BNP, troponin I, troponin T) in female amateur runners before and up until three days after a marathon, Clin. Lab. 54 (2008) 81-87.
    • [21] A.J. Siegel, E.L. Lewandrowski, K.Y. Chun, M.B. Sholar, A.J. Fischman, K.B. Lewandrowski, Changes in cardiac markers including B-natriuretic peptide in runners after the Boston marathon, Am. J. Cardiol. 88 (2001) 920-923.
    • [22] J.E. Trivax, B.A. Franklin, J.A. Goldstein, K.M. Chinnaiyan, M.J. Gallagher, A.T. deJong, et al., Acute cardiac effects of marathon running, J. Appl. Physiol. (1985) 108 (2010) 1148-1153.
    • [23] T. Eijsvogels, K. George, R. Shave, D. Gaze, B.D. Levine, M.T. Hopman, et al., Effect of prolonged walking on cardiac troponin levels, Am. J. Cardiol. 105 (2010) 267-272.
    • [24] S. Mohlenkamp, N. Lehmann, F. Breuckmann, M. Brocker-Preuss, K. Nassenstein, M. Halle, et al., Running: the risk of coronary events: prevalence and prognostic relevance of coronary atherosclerosis in marathon runners, Eur. Heart J. 29 (2008) 1903-1910.
    • [25] T.M. Eijsvogels, S. Molossi, D.C. Lee, M.S. Emery, P.D. Thompson, Exercise at the extremes: the amount of exercise to reduce cardiovascular events, J. Am. Coll. Cardiol. 67 (2016) 316-329.
    • [26] H. Tanaka, K.D. Monahan, D.R. Seals, Age-predicted maximal heart rate revisited, J. Am. Coll. Cardiol. 37 (2001) 153-156.
    • [27] M. Yoshimura, H. Yasue, K. Okumura, H. Ogawa, M. Jougasaki, M. Mukoyama, et al., Different secretion patterns of atrial natriuretic peptide and brain natriuretic peptide in patients with congestive heart failure, Circulation 87 (1993) 464-469.
    • [28] N.M. Benda, M.T. Hopman, A.P. van Dijk, D. Oxborough, K.P. George, D.H. Thijssen, et al., Impact of prolonged walking exercise on cardiac structure and function in cardiac patients versus healthy controls, Eur. J. Prev. Cardiol. (2016).
  • No related research data.
  • No similar publications.

Share - Bookmark

Published in

Funded by projects


Cite this article