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Wilson, Samantha Louise (2013)
Languages: English
Types: Doctoral thesis
Subjects: QM

Classified by OpenAIRE into

mesheuropmc: sense organs, eye diseases, genetic structures
The native corneal structure is highly organised and unified in architecture with structural and functional integration which mediates its transparency and mechanical strength. Two of the most demanding challenges in corneal tissue engineering are the replication of the native corneal stromal architecture and the preservation of stromal cell phenotype which prevents scar-like tissue formation. A concerted effort in this thesis has been devoted to the generation of a functional human corneal stromal model by the manipulation of chemical, topographical and cellular cues. To achieve this, previously built non-destructive, online, real-time monitoring techniques, micro-indentation and optical coherence tomography (OCT), which allow for the mechanical and contraction properties of corneal equivalents to be monitored, have been improved. These macroscopic parameters have been cross-validated by histological, imunohistochemical, morphological and genetic expression analysis.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

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    • BERNSTEIN, A.M., TWINING, S.S., WAREJCKA, D.J., TALL, E. and MASUR, S.K., 2007. Urokinase receptor cleavage: A crucial step in 14 fibroblast-to-myofibroblast differentiation. Molecular biology of the cell, 18(7), pp. 2716-2727.
    • LEVIN, A., NILSSON, F.E. VER HOEVE, J., WU, S., KAUFMAN, P.L. and ALM, A., 2011. Adler's Physiology of the Eye. 11th edition. Saunders Elsevier. Health Science Division, Philadelphia, USA.
    • 1963. Tropocollagen: significance of protease-induced alterations. Science, 139, 37-9.
    • SINGH, R., BARDEN, A., MORI, T. and BEILIN, L., 2002. Advanced glycation endproducts: a review (vol 44, pg 129, 2001). Diabetologia, 45(2), pp. 293-293.
  • Inferred research data

    The results below are discovered through our pilot algorithms. Let us know how we are doing!

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