LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Mendonça, Lívia Ribeiro; Veiga, Rafael Valente; Dattoli, Vitor Camilo Cavalcante; Figueiredo, Camila Alexandrina; Fiaccone, Rosemeire; Santos, Jackson; Cruz, Álvaro Augusto; Rodrigues, Laura Cunha; Cooper, Philip John; Pontes-de-Carvalho, Lain Carlos; Barreto, Maurício Lima; Alcantara-Neves, Neuza Maria (2012)
Publisher: Public Library of Science
Journal: PLoS Neglected Tropical Diseases
Languages: English
Types: Article
Subjects: qx_277, Research Article, Biology, qx_20, Infectious Diseases, wa_30, Medicine, Pulmonology, Asthma, Child Health, Pediatric Epidemiology, Epidemiology, RC955-962, Toxocariasis, Neglected Tropical Diseases, RA1-1270, Public aspects of medicine, ws_280, Clinical Immunology, Arctic medicine. Tropical medicine, Immunology, Public Health

Classified by OpenAIRE into

mesheuropmc: parasitic diseases
Background\ud \ud Toxocara canis and T. cati are parasites of dogs and cats, respectively, that infect humans and cause human toxocariasis. Infection may cause asthma-like symptoms but is often asymptomatic and is associated with a marked eosinophilia. Previous epidemiological studies indicate that T. canis infection may be associated with the development of atopy and asthma.\ud \ud Objectives\ud \ud To investigate possible associations between Toxocara spp. seropositivity and atopy and childhood wheezing in a population of children living in non-affluent areas of a large Latin American city.\ud \ud Methods\ud \ud The study was conducted in the city of Salvador, Brazil. Data on wheezing symptoms were collected by questionnaire, and atopy was measured by the presence of aeroallergen-specific IgE (sIgE). Skin prick test (SPT), total IgE and peripheral eosinophilia were measured. Toxocara seropositivity was determined by the presence of anti-Toxocara IgG antibodies, and intestinal helminth infections were determined by stool microscopy.\ud \ud Findings\ud \ud Children aged 4 to 11 years were studied, of whom 47% were seropositive for anti-Toxocara IgG; eosinophilia >4% occurred in 74.2% and >10% in 25.4%; 59.6% had elevated levels of total IgE; 36.8% had sIgE≥0.70 kU/L and 30.4% had SPT for at least one aeroallergen; 22.4% had current wheezing symptoms. Anti-Toxocara IgG was positively associated with elevated eosinophils counts, total IgE and the presence of specific IgE to aeroallergens but was inversely associated with skin prick test reactivity.\ud \ud Conclusion\ud \ud The prevalence of Toxocara seropositivity was high in the studied population of children living in conditions of poverty in urban Brazil. Toxocara infection, although associated with total IgE, sIgE and eosinophilia, may prevent the development of skin hypersensitivity to aeroallergens, possibly through increased polyclonal IgE and the induction of a modified Th2 immune reaction.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 1. von Mutius E, Weiland SK, Fritzsch C, Duhme H, Keil U (1998) Increasing prevalence of hay fever and atopy among children in Leipzig, East Germany. Lancet 351: 862-866.
    • 2. Falcone FH, Pritchard DI (2005) Parasite role reversal: worms on trial. Trends Parasitol 21: 157-160.
    • 3. Yazdanbakhsh M, van den Biggelaar A, Maizels RM (2001) Th2 responses without atopy: immunoregulation in chronic helminth infections and reduced allergic disease. Trends Immunol 22: 372-377.
    • 4. Fallon P, Mangan N (2007) Suppression of TH2-type allergic reactions by helminth infection. Nat Rev Immunol 7: 220-230.
    • 5. Cooper PJ (2009) Interactions between helminth parasites and allergy. Curr Opin Allergy Clin Immunol 9: 29-37.
    • 6. Alcantara-Neves NM, Veiga RV, Dattoli VC, Fiaccone RL, Esquivel R, et al. (2012) The effect of single and multiple infections on atopy and wheezing in children. J Allergy Clin Immunol 129: 359-367.
    • 7. Cooper PJ (2008) Toxocara canis infection: an important and neglected environmental risk factor for asthma? Clin Exp Allergy 38: 551-553.
    • 8. Rodrigues LC, Newcombe PJ, Cunha SS, Alcantara-Neves NM, Genser B, et al. (2008) Early infection with Trichuris trichiura and allergen skin test reactivity in later childhood. Clin Exp Allergy 38: 1769-1777.
    • 9. Moncayo A, Vaca M, Oviedo G, Erazo S, Quinzo I, et al. (2010) Risk factors for atopic and non-atopic asthma in a rural area of Ecuador. Thorax 65: 409-416.
    • 10. Araujo MI, Lopes AA, Medeiros M, Cruz AA, Sousa-Atta L, et al. (2000) Inverse association between skin response to aeroallergens and Schistosoma mansoni infection. Int Arch Allergy Immunol 123: 145-148.
    • 11. van den Biggelaar AH, Lopuhaa C, van Ree R, van der Zee JS, Jans J, et al. (2001) The prevalence of parasite infestation and house dust mite sensitization in Gabonese schoolchildren. Int Arch Allergy Immunol 126: 231-238.
    • 12. Cooper PJ, Chico ME, Rodrigues LC, Ordonez M, Strachan D, et al. (2003) Reduced risk of atopy among school-age children infected with geohelminth parasites in a rural area of the tropics. J Allergy Clin Immunol 111: 995-1000.
    • 13. Dagoye D, Bekele Z, Woldemichael K, Nida H, Yimam M, et al. (2003) Wheezing, allergy, and parasite infection in children in urban and rural Ethiopia. Am J Respir Crit Care Med 167: 1369-1373.
    • 14. Despommier D (2003) Toxocariasis: clinical aspects, epidemiology, medical ecology, and molecular aspects. Clin Microbiol Rev 16: 265-272.
    • 15. Chan PW, Anuar AK, Fong MY, Debruyne JA, Ibrahim J (2001) Toxocara seroprevalence and childhood asthma among Malaysian children. Pediatr Int 43: 350-353.
    • 16. Buijs J, Borsboom G, Renting M, Hilgersom WJ, van Wieringen JC, et al. (1997) Relationship between allergic manifestations and Toxocara seropositivity: a cross-sectional study among elementary school children. Eur Respir J 10: 1467- 1475.
    • 17. Gonzalez-Quintela A, Gude F, Campos J, Garea MT, Romero PA, et al. (2006) Toxocara infection seroprevalence and its relationship with atopic features in a general adult population. Int Arch Allergy Immunol 139: 317-324.
    • 18. Kustimur S, Dogruman Al F, Oguzulgen K, Bakir H, Maral I, et al. (2007) Toxocara seroprevalence in adults with bronchial asthma. Trans R Soc Trop Med Hyg 101: 270-274.
    • 19. Kuk S, Ozel E, Ogˇuztu¨ rk H, Kirkil G, Kaplan M (2006) Seroprevalence of Toxocara antibodies in patients with adult asthma. South Med J 99: 719-722.
    • 20. Walsh MG (2011) Toxocara infection and diminished lung function in a nationally representative sample from the United States population. Int J Parasitol 41: 243-247.
    • 21. Zacharasiewicz A, Auer H, Brath H, Stohlhofer B, Frank W, et al. (2000) [Toxocara and bronchial hyperreactivity-results of a seroprevalence study]. Wien Klin Wochenschr 112: 922-926.
    • 22. Sharghi N, Schantz PM, Caramico L, Ballas K, Teague BA, et al. (2001) Environmental exposure to Toxocara as a possible risk factor for asthma: a clinic-based case-control study. Clin Infect Dis 32: E111-116.
    • 23. Kennedy MW, Maizels RM, Meghji M, Young L, Qureshi F, et al. (1987) Speciesspecific and common epitopes on the secreted and surface antigens of Toxocara cati and Toxocara canis infective larvae. Parasite Immunol 9: 407-420.
    • 24. Dattoli VC, Freire SM, Mendonca LR, Santos PC, Meyer R, et al. (2011) Toxocara canis infection is associated with eosinophilia and total IgE in blood donors from a large Brazilian centre. Trop Med Int Health 16: 514-517.
    • 25. Barreto ML, Genser B, Strina A, Teixeira MG, Assis AM, et al. (2007) Effect of city-wide sanitation programme on reduction in rate of childhood diarrhoea in northeast Brazil: assessment by two cohort studies. Lancet 370: 1622-1628.
    • 26. Barreto ML, Cunha SS, Alcaˆntara-Neves N, Carvalho LP, Cruz AA, et al. (2006) Risk factors and immunological pathways for asthma and other allergic diseases in children: background and methodology of a longitudinal study in a large urban center in Northeastern Brazil (Salvador-SCAALA study). BMC Pulm Med 6: 15.
    • 27. Hoffman WA, Pons JA, Janer JL (1934) The sedimentation concentration method in Schistosomiasis mansoni. Puerto Rico J Public Health 9: 281- 298.
    • 28. Katz N, Chaves A, Pellegrino J (1972) A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni. Rev Inst Med Trop Sao Paulo 14: 397-400.
    • 29. Figueiredo C, Barreto M, Rodrigues L, Cooper P, Silva N, et al. (2010) Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network. Infect Immun 78: 3160-3167.
    • 30. de Savigny D (1975) In vitro maintenance of Toxocara canis larvae and a simple method for the production of Toxocara ES antigen for the uses in serodiagnostic test for visceral larva migrans. Journal of Parasitology 61: 781-782.
    • 31. Alcaˆntara-Neves NM, dos Santos AB, Mendonc¸a LR, Figueiredo CA, Pontesde-Carvalho L (2008) An improved method to obtain antigen-excreting Toxocara canis larvae. Exp Parasitol 119: 349-351.
    • 32. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin-Phenol reagents. J Biol Chem 193: 265-275.
    • 33. De Savigny DH, Tizard IR (1975) Serodiagnosis of Toxocara larva migrans visceral. Candian Journal of Public Health 66: 52-56.
    • 34. Matos SM, Jesus SR, Saldiva SR, Prado MS, D'Innocenzo S, et al. (2011) Overweight, asthma symptoms, atopy and pulmonary function in children of 4- 12 years of age: findings from the SCAALA cohort in Salvador, Bahia, Brazil. Public Health Nutr 14: 1270-1278.
    • 35. Barreto ML, Cunha SS, Fiaccone R, Esquivel R, Amorim LD, et al. (2010) Poverty, dirt, infections and non-atopic wheezing in children from a Brazilian urban center. Respir Res 11: 167.
    • 36. Hotez PJ, Wilkins PP (2009) Toxocariasis: America's most common neglected infection of poverty and a helminthiasis of global importance? PLoS Negl Trop Dis 3: e400.
    • 37. Chieffi PP, Santos SV, Queiroz ML, Lescano SA (2009) Human toxocariasis: contribution by Brazilian researchers. Rev Inst Med Trop Sao Paulo 51: 301- 308.
    • 38. Damian MM, Martins M, Sardinha JF, Souza LO, Chaves A, et al. (2007) [Frequency of the antibody anti-Toxocara canis in a community along the Uatuma river, State of Amazonas]. Rev Soc Bras Med Trop 40: 661-664.
    • 39. Alonso JM, Bojanich MV, Chamorro M, Gorodner JO (2000) Toxocara seroprevalence in children from a subtropical city in Argentina. Rev Inst Med Trop Sao Paulo 42: 235-237.
    • 40. Espinoza YA, Huapaya PH, Roldan WH, Jimenez S, Arce Z, et al. (2008) Clinical and serological evidence of Toxocara infection in school children from Morrope district, Lambayeque, Peru. Rev Inst Med Trop Sao Paulo 50: 101-105.
    • 41. Regis SC, Mendonca LR, Silva Ndos S, Dattoli VC, Alcantara-Neves NM, et al. (2011) Seroprevalence and risk factors for canine toxocariasis by detection of specific IgG as a marker of infection in dogs from Salvador, Brazil. Acta Trop 120: 46-51.
    • 42. Pecinali NR, Gomes RN, Amendoeira FC, Bastos AC, Martins MJ, et al. (2005) Influence of murine Toxocara canis infection on plasma and bronchoalveolar lavage fluid eosinophil numbers and its correlation with cytokine levels. Vet Parasitol 134: 121-130.
    • 43. Martin UO, Machuca PB, Demonte MA, Contini L (2008) [Analysis of children with a presumptive diagnosis of toxocariasis in Santa Fe, Argentina]. Medicina (B Aires) 68: 353-357.
    • 44. Johansson E, Aponno M, Lundberg M, van Hage-Hamsten M (2001) Allergenic cross-reactivity between the nematode Anisakis simplex and the dust mites Acarus siro, Lepidoglyphus destructor, Tyrophagus putrescentiae, and Dermatophagoides pteronyssinus. Allergy 56: 660-666.
    • 45. Ponte JC, Junqueira SB, Veiga RV, Barreto ML, Pontes-de-Carvalho LC, et al. (2011) A study on the immunological basis of the dissociation between type Ihypersensitivity skin reactions to Blomia tropicalis antigens and serum anti-B. tropicalis IgE antibodies. BMC Immunol 12: 34.
    • 46. Acevedo N, Sanchez J, Erler A, Mercado D, Briza P, et al. (2009) IgE crossreactivity between Ascaris and domestic mite allergens: the role of tropomyosin and the nematode polyprotein ABA-1. Allergy 64: 1635-1643.
    • 47. Yazdanbakhsh M, Kremsner PG, van Ree R (2002) Allergy, parasites, and the hygiene hypothesis. Science 296: 490-494.
    • 48. Kuijk LM, van Die I (2010) Worms to the rescue: can worm glycans protect from autoimmune diseases? IUBMB Life 62: 303-312.
    • 49. Mari A, Iacovacci P, Afferni C, Barletta B, Tinghino R, et al. (1999) Specific IgE to cross-reactive carbohydrate determinants strongly affect the in vitro diagnosis of allergic diseases. J Allergy Clin Immunol 103: 1005-1011.
    • 50. Maizels RM, Pearce EJ, Artis D, Yazdanbakhsh M, Wynn TA (2009) Regulation of pathogenesis and immunity in helminth infections. J Exp Med 206: 2059-2066.
    • 51. Figueiredo CA, Barreto ML, Rodrigues LC, Cooper PJ, Silva NB, et al. (2010) Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network. Infect Immun 78: 3160-3167.
    • 52. Platts-Mills T, Vaughan J, Squillace S, Woodfolk J, Sporik R (2001) Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study. Lancet 357: 752-756.
    • 53. van Riet E, Hartgers FC, Yazdanbakhsh M (2007) Chronic helminth infections induce immunomodulation: consequences and mechanisms. Immunobiology 212: 475-490.
  • No similar publications.

Share - Bookmark

Funded by projects

  • WT | The impact of urbanization, ...

Cite this article