LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Yates, Jennifer
Languages: English
Types: Doctoral thesis
Subjects: QD
The development of template directed synthesis towards the formation of interlocked\ud architectures has allowed for the synthesis of a variety of rotaxanes. Chapter 1 covers the\ud history of rotaxanes including their nomenclature and methods of formation. An overview of\ud the intermolecular interactions used to facilitate the synthesis of these architectures is\ud described and examples of template directed synthesis and properties of rotaxanes are\ud discussed.\ud In Chapter 2 the use of the Diels-Alder reaction towards formation of rotaxanes in a\ud ‘threading followed by stoppering’ protocol is covered. The synthesis of [n]rotaxanes is\ud described with secondary ammonium ions, a novel perimidine benzimidazole and\ud bispyridinium binding templates integrated into threads.\ud In Chapter 3 a novel binding template was developed, incorporating a triazole into a\ud dibenzylammonium binding motif. Binding studies were carried out and [n]rotaxanes were\ud synthesised using this motif with the groups Diels-Alder ‘threading followed by stoppering’\ud protocol.\ud Chapter 4 discusses the modification of the DB24C8 macrocycle with the aim to enhance\ud binding interactions with a variety of binding motifs. Two macrocycles were successfully\ud synthesised and their binding affinities calculated with known and novel binding templates\ud investigated in the previous chapters.\ud The work in this thesis shows a Diels-Alder stoppering reaction can be successfully used to\ud synthesise [n]rotaxanes with a variety of binding templates including novel templates\ud discovered during this project. During the work it was also revealed that modifications to\ud known binding templates can provide an enhancement in binding interactions in comparison\ud to their unmodified predecessors.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • Chapter 6 Andersson, M.; Linke, M.; Chambron, J. C.; Davidsson, J.; Heitz, V.; Hammarstrom, L.; Sauvage, J. P. J. Am. Chem. Soc. 2002, 124, 4347-4362. Liu, Y.; Bruneau, A.; He, J. M.; Abliz, Z. Org. Lett. 2008, 10, 765-768. Nygaard, S.; Hansen, S. W.; Huffman, J. C.; Jensen, F.; Flood, A. H.; Jeppesen, J. O. J. Am. Chem. Soc. 2007, 129, 7354-7363. Weck, M.; Mohr, B.; Sauvage, J. P.; Grubbs, R. H. J. Org. Chem. 1999, 64, 5463-5471.
    • Amabilino, D. B.; Stoddart, J. F. Chem. Rev. 1995, 95, 2725-2828. Swiegers, G. F.; Malefetse, T. J. Chem. Rev. 2000, 100, 3483-3537. Blankenship, J. W.; Dawson, P. E. Protein Sci. 2007, 16, 1249-1256. Meyer, C. D.; Forgan, R. S.; Chichak, K. S.; Peters, A. J.; Tangchaivang, N.; Cave, G. W. V.; Khan, S. I.; Cantrill, S. J.; Stoddart, J. F. Chem. Eur. J. 2010, 16, 12570-12581.
    • Lukin, O.; Muller, W. M.; Muller, U.; Kaufmann, A.; Schmidt, C.; Leszczynski, J.; Vogtle, F. Chem. Eur. J. 2003, 9, 3507-3517. Schalley, C. A.; Reckien, W.; Peyerimhoff, S.; Baytekin, B.; Vogtle, F. Chem. Eur. J. 2004, 10, 4777-4789.
    • Ashton, P. R.; Philp, D.; Spencer, N.; Stoddart, J. F. J. Chem. Soc., Chem. Commun. 1992, 1124-1128.
    • Prikhod'ko, A. I.; Durola, F.; Sauvage, J. P. J. Am. Chem. Soc. 2008, 130, 448-449.
    • Harrison, I. T.; S., H. J. Am. Chem. Soc. 1967, 89, 5723-5724. Wu, J.; Leung, K. C. F.; Stoddart, J. F. PNAS 2007, 104, 17266-17271. Kolchinski, A. G.; Busch, D. H.; Alcock, N. W. J. Chem. Soc., Chem. Commun. 1995, 1289-1291.
  • No related research data.
  • No similar publications.

Share - Bookmark

Cite this article