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Phillips, Daniel J.
Languages: English
Types: Doctoral thesis
Subjects: QR, QD
The ability to programme and manipulate small changes at the molecular level to elicit a dramatically enhanced macroscopic response makes “stimuli-responsive” materials a fascinating topic of study. This work seeks to manipulate the solubility switch associated with polymers exhibiting a Lower Critical Solution Temperature without a temperature change (‘isothermally’). This concept, as overviewed in Chapter 1, has attractive applications in biological settings where variations in in vivo microenvironments may be used to produce increasingly targeted delivery vehicles, and to mediate cell membrane interactions.\ud \ud Using controlled radical polymerisation, pre-designed backbones, end-group(s) or side-chains can be targeted to control the hydrophilic-hydrophobic balance of a thermo-responsive system. Chapters 2 and 3 investigate this concept, using the chemical reduction of a functional polymer backbone or end-group to trigger isothermal polymer precipitation or solubilisation in linear and nanoparticle systems respectively. Chapter 4 applies a metal-ligand binding motif, prevalent in bacteria, to end-functional polymers as an alternative means of promoting isothermal polymer precipitation. This binding motif is then transferred to a nanoparticle system in Chapter 5, and used for the first time to prepare an optical, particle-based biosensor for the detection of physiologically relevant iron concentrations. Finally, Chapter 6 describes the enzymatic degradation of a polymer side-chain as a means of triggering isothermal precipitation and considers its potential to mediate cellular uptake.\ud \ud In summary, a series of functionalised polymers and nanoparticles have been synthesised and their (isothermal) responses characterised. These materials may have exciting potential in the emerging field of nanomedicine.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 2. Isothermally-Responsive, Biodegradable Poly(disulfide)s 4. Isothermally-Responsive Polymers Triggered by Selective Binding of Fe3+ to Siderophoric Catechol End-Groups of Poly(L-lactic acid) Films Using Dip-Pen Nanolithography. Small 2011, 7, 226-229.
    • Guyomard-Lack, A. l.; Delorme, N.; Moreau, C. l.; Bardeau, J.-F. o.; Cathala, B. Site-Selective Surface Modification Using Enzymatic Soft Lithography. Langmuir 2011, 27, 7629-7634.
    • Vincent, J. B.; Crowder, M. W.; Averill, B. A. Hydrolysis of phosphate monoesters: a biological problem with multiple chemical solutions. Trends Biochem. Sci. 1992, 17, 105-110.
    • Golub, E. E.; Boesze-Battaglia, K. The role of alkaline phosphatase in mineralization. Curr. Opin. Orthop. 2007, 18, 444-448.
    • Prim. Care 2008, 35, 215-237.
    • Shaver, W. A.; Bhatt, H.; Combes, B. Low serum alkaline phosphatase activity in Wilson's disease. Hepatology 1986, 6, 859-863.
    • Yang, Z.; Gu, H.; Fu, D.; Gao, P.; Lam, J. K.; Xu, B. Enzymatic Formation of Supramolecular Hydrogels. Adv. Mater. 2004, 16, 1440-1444.
    • Wang, C.; Chen, Q.; Wang, Z.; Zhang, X. An Enzyme-Responsive Polymeric Superamphiphile. Angew. Chem. Int. Ed. 2010, 49, 8612-8615.
    • Zelzer, M.; McNamara, L. E.; Scurr, D. J.; Alexander, M. R.; Dalby, M. J.; Ulijn, R. V. Phosphatase responsive peptide surfaces. J. Mater. Chem. 2012, 22, 12229-12237.
    • Schattling, P.; Jochum, F. D.; Theato, P. Multi-stimuli responsive polymers - the all-in-one talents. Polym. Chem. 2014, 5, 25-36.
    • Xia, Y.; Burke, N. A. D.; Stöver, H. D. H. End Group Effect on the Thermal Response of Narrow-Disperse Poly(N-isopropylacrylamide) Prepared by Atom Transfer Radical Polymerization. Macromolecules 2006, 39, 2275- 2283.
    • López -Préez, P. M.; da Silva, R. M. P.; Pashkuleva, I.; Parra, F.; Reis, R. L.; San Roman, J. Hydrophobic−Electrostatic Balance Driving the LCST Offset 256 Aggregation−Redissolution Behavior of N-Alkylacrylamide-Based Ionic Terpolymers. Langmuir 2009, 26, 5934-5941.
    • Phosphatase/temperature responsive poly(2-isopropyl-2-oxazoline). Polym.
    • Chem. 2011, 2, 306-308.
    • Kanazawa, H. Thermally responsive chromatographic materials using functional polymers. J. Sep. Sci. 2007, 30, 1646-1656.
    • Chung, J. E.; Yokoyama, M.; Yamato, M.; Aoyagi, T.; Sakurai, Y.; Okano, T. Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of poly(N-isopropylacrylamide) and poly(butylmethacrylate). J. Control. Rel. 1999, 62, 115-127.
    • Biomater. Sci. 2013, 1, 434-442.
    • Kono, K.; Nakai, R.; Morimoto, K.; Takagishi, T. Temperature-dependent interaction of thermo-sensitive polymer-modified liposomes with CV1 cells.
    • FEBS Lett. 1999, 456, 306-310.
    • Choi, S. H.; Yoon, J. J.; Park, T. G. Galactosylated Poly(Nisopropylacrylamide) Hydrogel Submicrometer Particles for Specific Cellular Uptake within Hepatocytes. J. Colloid Interface Sci. 2002, 251, 57-63.
    • Cancer Ther. 2005, 4, 1076-1085.
    • MacEwan, S. R.; Chilkoti, A. Applications of elastin-like polypeptides in drug delivery. J. Control. Rel. 2014, 190, 314-330.
    • Stockert, R. J. The asialoglycoprotein receptor: relationships between structure, function, and expression. Physiol. Rev. 1995, 75, 591-609.
    • Yoo, H. S.; Park, T. G. Folate receptor targeted biodegradable polymeric doxorubicin micelles. J. Control. Rel. 2004, 96, 273-283.
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