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Maunder, Helen E.; Taylor, Geraldine; Leppard, Keith; Easton, A. J. (Andrew J.) (2015)
Publisher: Elsevier Ltd.
Languages: English
Types: Article
Subjects: QR355

Classified by OpenAIRE into

mesheuropmc: parasitic diseases
Pneumonia virus of mice (PVM) infection of BALB/c mice induces bronchiolitis leading to a fatal pneumonia in a dose-dependent manner, closely paralleling the development of severe disease during human respiratory syncytial virus infection in man, and is thus a recognised model in which to study the pathogenesis of pneumoviruses. This model system was used to investigate delivery of the internal structural proteins of PVM as a potential vaccination strategy to protect against pneumovirus disease. Replication-deficient recombinant human adenovirus serotype 5 (rAd5) vectors were constructed that expressed the M or N gene of PVM pathogenic strain J3666. Intranasal delivery of these rAd5 vectors gave protection against a lethal challenge dose of PVM in three different mouse strains, and protection lasted for at least 20 weeks post-immunisation. Whilst the PVM-specific antibody response isuch animals was weak and inconsistent, rAd5N primed a strong PVM-specific CD8+ T cell response and, to a lesser extent, a CD4+ T cell response. These findings suggest that protection induced by rAd5N was mediated by T-cells rather than serum antibody.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • [1] Easton AJ, Ling R. Mononegavirales. In: Mahy BWJ, Van Regenmortel MHV, editors. Encyclopedia of Virology, 3rd edn. Oxford: Elsevier; 2008. p. 324-34.
    • [2] Nair H, Nokes DJ, Gessner BD, Dherani M, Madhi SA, Singleton RJ, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet. 2010;375:1545-55.
    • [3] Hall CB, Weinberg GA, Iwane MK, Blumkin AK, Edwards KM, Staat MA, et al. The burden of respiratory syncytial virus infection in young children. New Engl J Med. 2009;360:588-98.
    • [4] Hall CB, Walsh EE, Long CE, Schnabel KC. Immunity to and frequency of reinfection with respiratory syncytial virus. J Infect Dis. 1991;163:693-8.
    • [5] Cowton VM, McGivern DR, Fearns R. Unravelling the complexities of respiratory syncytial virus RNA synthesis. J Gen Virol. 2006;87:1805-21.
  • Inferred research data

    The results below are discovered through our pilot algorithms. Let us know how we are doing!

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