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Barnard, A; Long, K; Yeo, DJ; Miles, JA; Azzarito, V; Burslem, GM; Prabhakaran, P; Edwards, TA; Wilson, AJ (2014)
Publisher: Royal Society of Chemistry
Languages: English
Types: Article
Subjects:
α-Helix mediated protein-protein interactions are of major therapeutic importance. As such, the design of inhibitors of this class of interaction is of significant interest. We present methodology to modify N-alkylated aromatic oligoamide α-helix mimetics using 'click' chemistry. The effect is shown to modulate the binding properties of a series of selective p53/hDM2 inhibitors.
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    • J. A. Stuckey and S. Wang, J. Med. Chem., 2012, 55, 4664- B. J. Smith, I. P. Street, H. Yang, D. C. S. Huang and 4682. K. G. Watson, Nat. Chem. Biol., 2013, 9, 390-397.
    • 50 G. Lessene, P. E. Czabotar, B. E. Sleebs, K. Zobel, 51 M. L. Stewart, E. Fire, A. E. Keating and L. D. Walensky, K. N. Lowes, J. M. Adams, J. B. Baell, P. M. Colman, Nat. Chem. Biol., 2010, 6, 595-601.
    • K. Deshayes, W. J. Fairbrother, J. A. Flygare, P. Gibbons, 52 C. J. Wienken, P. Baaske, U. Rothbauer, D. Braun and W. J. A. Kersten, S. Kulasegaram, R. M. Moss, J. P. Parisot, S. Duhr, Nat. Commun., 2013, 1, 7.
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  • BioEntity Site Name
    1ycrProtein Data Bank

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