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Shirinzadeh, Hanif; Ince, Elif; Westwell, Andrew David; Gurer-Orhan, Hande; Suzen, Sibel (2016)
Publisher: Informa Healthcare
Languages: English
Types: Article
Subjects: RM
Melatonin (MLT) is a well-known free-radical scavenger, involving in the prevention of cellular damage that can lead to cancer, ageing and a variety of neurodegenerative diseases. Research on MLT-related compounds has been required to optimise the maximum pharmaceutical activity with the lowest side effects. In our ongoing research, we have synthesized new indole-based MLT analogues as potential antioxidant agents by modifying the MLT molecule. In this study, we build on previous findings, through the synthesis, characterization and in vitro antioxidant profiling of a series of new indole-based MLT analogues which possess triazole, thiadiazole and carbothioamides on the third position on the indole ring. In vitro antioxidant activity was investigated by evaluating their reducing effect against oxidation of a redox sensitive fluorescent probe and their radical scavenging activity was assessed via the DPPH assay. In addition, in vitro cytotoxic effects of newly synthesized compounds were investigated in CHO-K1 cells using the MTT assay.
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    • 1) Valko M, Rhodes CJ, Moncol J, et al. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact2006; 160(1): 1-40. doi: 10.1016/j.cbi.2005.12.009 2) Wu JQ, Kosten TR, Zhang XY. Free radicals, antioxidant defense systems, and schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry2013: 46(0): 200-206. doi: http://dx.doi.org/10.1016/j.pnpbp.2013.02.015 3) Bonnefont-Rousselot D, Collin F. Melatonin: action as antioxidant and potential applications in human disease and aging.Toxicology 2010:278: 55-67.
    • 4) Valko M, Leibfritz D, Moncol J, et al. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007: 39(1): 44-84. doi: http://dx.doi.org/10.1016/j.biocel.2006.07.001
    • 31) Chen H, Li, Z. and Han, Y. Synthesis and fungicidal activity against Rhizoctonia solani of 2- alkyl (Alkylthio)-5-pyrazolyl-1,3,4-oxadiazoles (Thiadiazoles). J Agric Food Chem (Nov 2000). 48: 11),5312-5315.
    • 32) Mathew V, Gıles D, Keshavayya J. et al. Studies on synthesis and pharmacological activities of 1,2,4-triazolo[3,4-b]1,3,4-thiadiazoles and their dihydro analogues. Arch Pharm (Weinheim) (Apr 2009). 342: 4),210-222.
    • 33) Kharadı G. J. Antioxidant, tautomerism and antibacterial studies of Fe(III)-1,2,4-triazole based complexes. Spectrochim Acta A Mol Biomol Spectrosc (Jun 2013). (110),311-316.
    • 34) Bansod S, Kamble R. Synthesis of novel 2-(3′-aryl-sydnon-4′-ylidene)-5′-substituted-[1,3,4]- thiadiazolylamines and [1,3,4]-thiadiazol-2′-yl-3-oxo-[1,2,4]-triazoles as antimicrobial agents. Med Chem Res(2012). 21:867-873. DOI 10.1007/s00044-011-9596-2
    • 35) Siddiqui N, Alam MS, Ahsan W. Synthesis, anticonvulsant and toxicity evaluation of 2-(1Hindol-3-yl)acetyl-N-(substituted phenyl)hydrazine carbothioamides and their related heterocyclic derivatives. Acta Pharm. (Zagreb, Croatia) 2008: 58(4): 445-454. doi: 10.2478/v10007-008-0025-0
    • 36) Siddiqui N, Alam, MS. 5-[(1H-indol-3-yl)methyl]-N-(phenyl)-1,2,4-thiadiazol-2-amine derivatives: synthesis and biological screening. Biosci.,Biotechnol. Res. Asia2009: 6(1): 261- 264.
    • 37) Lautraite S, Bigot-Lasserre D, Bars R, et al. Optimisation of cell-based assays for medium throughput screening of oxidative stress. ToxicolIn Vitro2003:17:207-220.
    • 38) Blois MS. Antioxidant determination by the use of stable free radical. Nature1958: 181: 1199-1200.
    • 39) Orhan H, Gurer-Orhan H, Vriese E, et al. Application of lipid peroxidation and protein oxidation biomarkers for oxidative damage in mammalian cells. A comparison with two fluorescent probes. Toxicology in Vitro2006: 20: 1005-1013.
    • 40) Papaetis GS, Syrigos KN. Sunitinib: a multitargeted receptor tyrosine kinase inhibitor in the era of molecular cancer therapies. BioDrugs2009: 23(6): 377-389. doi: 10.2165/11318860- 000000000-00000
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