Remember Me
Or use your Academic/Social account:


You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.


Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message


Verify Password:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:

OpenAIRE is about to release its new face with lots of new content and services.
During September, you may notice downtime in services, while some functionalities (e.g. user registration, login, validation, claiming) will be temporarily disabled.
We apologize for the inconvenience, please stay tuned!
For further information please contact helpdesk[at]openaire.eu

fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Hackett, Katie L.; Deane, Katherine H. O.; Strassheim, Victoria; Deary, Vincent; Rapley, Tim; Newton, Julia L.; Ng, Wan-Fai (2015)
Publisher: Oxford University Press
Journal: Rheumatology (Oxford, England)
Languages: English
Types: Article
Subjects: Clinical Science, fatigue, pain, interventions, Sjogren’s syndrome, non-pharmacological, dryness, function, C800, rheumatology, systematic review
Objective. To evaluate the effects of non-pharmacological interventions for primary SS (pSS) on outcomes falling within the World Health Organization International Classification of Functioning Disability and Health domains.\ud \ud Methods. We searched the following databases from inception to September 2014: Cochrane Database of Systematic Reviews; Medline; Embase; PsychINFO; CINAHL; and clinical trials registers. We included randomized controlled trials of any non-pharmacological intervention. Two authors independently reviewed titles and abstracts against the inclusion/exclusion criteria and independently assessed trial quality and extracted data.\ud \ud Results. A total of 1463 studies were identified, from which 17 full text articles were screened and 5 studies were included in the review; a total of 130 participants were randomized. The included studies investigated the effectiveness of an oral lubricating device for dry mouth, acupuncture for dry mouth, lacrimal punctum plugs for dry eyes and psychodynamic group therapy for coping with symptoms. Overall, the studies were of low quality and at high risk of bias. Although one study showed punctum plugs to improve dry eyes, the sample size was relatively small.\ud \ud Conclusion. Further high-quality studies to evaluate non-pharmacological interventions for PSS are needed.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 2 Gabriel SE, Michaud K. Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases. Arthritis Res Ther 2009;11:229.
    • 3 Vitali C, Bombardieri S, Jonsson R et al. Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American European Consensus Group. Ann Rheum Dis 2002;61:554 8.
    • 4 Segal BM, Pogatchnik B, Henn L, Rudser K, Sivils KM. Pain severity and neuropathic pain symptoms in primary Sjogren's Syndrome: a comparison study of seropositive and seronegative Sjogren's Syndrome patients. Arthritis Care Res 2013;65:1291 8.
    • 5 Goodchild CE, Treharne GJ, Booth DA, Bowman SJ. Daytime patterning of fatigue and its associations with the previous night's discomfort and poor sleep among women with primary Sjogren's syndrome or rheumatoid arthritis. Musculoskeletal Care 2010;8:107 17.
    • 6 Haldorsen K, Bjelland I, Bolstad AI, Jonsson R, Brun JG. A five-year prospective study of fatigue in primary Sjogren's syndrome. Arthritis Res Ther 2011;13:R167.
    • 7 Hartkamp A, Geenen R, Godaert GLR et al. Effect of dehydroepiandrosterone administration on fatigue, wellbeing, and functioning in women with primary Sjo¨ gren syndrome: a randomised controlled trial. Ann Rheum Dis 2008;67:91 7.
    • 8 Gono T, Kawaguchi Y, Katsumata Y et al. Clinical manifestations of neurological involvement in primary Sjogren's syndrome. Clin Rheumatol 2011;30:485 90.
    • 9 Tobon GJ, Pers JO, Devauchelle-Pensec V, Youinou P. Neurological disorders in primary Sjogren's Syndrome. Autoimmune Dis 2012;2012:645967.
    • 10 Newton JL, Frith J, Powell D et al. Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjogren's syndrome. Ann Rheum Dis 2012;71:1973 9.
    • 11 Westhoff G, Dorner T, Zink A. Fatigue and depression predict physician visits and work disability in women with primary Sjogren's syndrome: results from a cohort study. Rheumatology 2012;51:262 9.
    • 12 Patel R, Shahane A. The epidemiology of Sjogren's syndrome. Clin Epidemiol 2014;6:247 55.
    • 13 Hansen A, Daridon C, Dorner T. What do we know about memory B cells in primary Sjogren's syndrome? Autoimmun Rev 2010;9:600 3.
    • 14 Hackett K, Newton J, Frith J et al. Impaired functional status in primary Sjogren's syndrome. Arthritis Care Res 2012;64:1760 4.
    • 15 Lendrem D, Mitchell S, McMeekin P et al. Health-related utility values of patients with primary Sjogren's syndrome and its predictors. Ann Rheum Dis 2014;73:1362 8.
    • 16 Bowman SJ, Ibrahim GH, Holmes G, Hamburger J, Ainsworth JR. Estimating the prevalence among Caucasian women of primary Sjogren's syndrome in two general practices in Birmingham, UK. Scand J Rheumatol 2004;33:39 43.
    • 17 Callaghan R, Prabu A, Allan RB et al. Direct healthcare costs and predictors of costs in patients with primary Sjogren's syndrome. Rheumatology 2007;46:105 11.
    • 18 Segal B, Bowman SJ, Fox PC et al. Primary Sjogren's Syndrome: health experiences and predictors of health quality among patients in the United States. Health Qual life Outcomes 2009;7:46.
    • 19 Meijer JM, Meiners PM, Huddleston Slater JJ et al. Healthrelated quality of life, employment and disability in patients with Sjogren's syndrome. Rheumatology 2009;48:1077 82.
    • 20 Guillemin F, Iversen MD, Rat AC, Osborne R, Petersson IF. Nonpharmacologic interventions need outcomes for evaluating complex interventions in rheumatic diseases. J Rheumatol 2011;38:1803 5.
    • 21 Cockshott Z, Hewlett S, Almeida C et al. Rheumatoid arthritis patient education in the UK what is on offer and how is it delivered? Rheumatology 2005;44(Suppl 1):i148. Abstract 382.
    • 22 Hackett KL, Newton JL, Ng WF. Occupational therapy: a potentially valuable intervention for people with primary Sjogren's syndrome. Br J Occup Ther 2012;75:247 9.
    • 23 Valim V, Trevisani VF, de Sousa JM, Vilela VS, Belfort R Jr. Current approach to dry eye disease. Clin Rev Allergy Immunol 2014; Advance Access published 1 August 2014, doi: 10.1007/s12016-014-8438-7.
    • 24 O'Sullivan EM, Higginson IJ. Clinical effectiveness and safety of acupuncture in the treatment of irradiationinduced xerostomia in patients with head and neck cancer: a systematic review. Acupunct Med 2010;28:191 9.
    • 25 Ramos-Casals M, Tzioufas AG, Stone JH, Siso´ A, Bosch X. Treatment of primary Sjo¨ gren syndrome: a systematic review. JAMA 2010;304:452 60.
    • 26 WHO. International Classification of Functioning, Disability and Health (ICF). Geneva, Switzerland: World Health Organization, 2001.
    • 27 Lefebvre C, Manheimer E, Glanville J. Searching for studies. In: Higgins JP, Green S, eds. Cochrane handbook for systematic reviews of interventions. Chichester: John Wiley and Sons Ltd, 2008: 95 150.
    • 28 Higgins JPT, Altman DG. Assessing risk of bias in included studies. In: Higgins JPT, Green S, eds. Cochrane handbook for systematic reviews of interventions. Chichester: Wiley-Blackwell, 2008: 187 241.
    • 29 Poulsen A. Psychodynamic, time-limited group therapy in rheumatic disease-a controlled study with special reference to alexithymia. Psychother Psychosom 1991;56:12 23.
    • 30 List T, Lundeberg T, Lundstrom I, Lindstrom F, Ravald N. The effect of acupuncture in the treatment of patients with primary Sjogren's syndrome. A controlled study. Acta Odontol Scand 1998;56:95 9.
    • 31 Frost PM, Shirlaw PJ, Challacombe SJ et al. Impact of wearing an intra-oral lubricating device on oral health in dry mouth patients. Oral Dis 2006;12:57 62.
    • 32 Mansour K, Leonhardt CJ, Kalk WW et al. Lacrimal punctum occlusion in the treatment of severe keratoconjunctivitis Sicca caused by Sjogren syndrome: a uniocular evaluation. Cornea 2007;26:147 50.
    • 33 Qiu W, Liu Z, Ao M, Li X, Wang W. Punctal plugs versus artificial tears for treating primary Sjogren's syndrome with keratoconjunctivitis SICCA: a comparative observation of their effects on visual function. Rheumatol Int 2013;33:2543 8.
    • 34 Manthorpe R, Oxholm P, Prause JU, Schiodt M. The Copenhagen criteria for Sjogren's syndrome. Scand J Rheumatol Suppl 1986;61:19 21.
    • 35 Fox RI, Saito I. Criteria for diagnosis of Sjogren's syndrome. Rheum Dis Clin North Am 1994;20:391 407.
    • 36 Vitali C, Bombardieri S, Moutsopoulos HM et al. Assessment of the European classification criteria for Sjogren's syndrome in a series of clinically defined cases: results of a prospective multicentre study. The European Study Group on Diagnostic Criteria for Sjogren's Syndrome. Ann Rheum Dis 1996;55:116 21.
    • 37 Ervin AM, Wojciechowski R, Schein O. Punctal occlusion for dry eye syndrome. Cochrane Database Syst Rev 2010(9): CD006775.
    • 38 White PD, Goldsmith KA, Johnson AL et al. Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial. Lancet 2011;377:823 36.
    • 39 Strombeck BE, Theander E, Jacobsson LT. Effects of exercise on aerobic capacity and fatigue in women with primary Sjogren's syndrome. Rheumatology 2007;46: 868 71.
    • 40 O'Connor D, Green S, Higgins JP. Defining the review question and developing criteria for including studies. In: Higgins JP, Green S, eds. Cochrane handbook for systematic reviews of interventions. Chichester: John Wiley and Sons, 2008: 83 94.
    • 41 van Leeuwen N. Management of fatigue in sicca syndromes. In: Nederlands Trial Register, 2012. http://www. trialregister.nl/trialreg/admin/rctview.asp?TC=3514 (18 June 2015, date last accessed).
  • No related research data.
  • No similar publications.

Share - Bookmark

Cite this article

Cookies make it easier for us to provide you with our services. With the usage of our services you permit us to use cookies.
More information Ok