LOGIN TO YOUR ACCOUNT

Username
Password
Remember Me
Or use your Academic/Social account:

CREATE AN ACCOUNT

Or use your Academic/Social account:

Congratulations!

You have just completed your registration at OpenAire.

Before you can login to the site, you will need to activate your account. An e-mail will be sent to you with the proper instructions.

Important!

Please note that this site is currently undergoing Beta testing.
Any new content you create is not guaranteed to be present to the final version of the site upon release.

Thank you for your patience,
OpenAire Dev Team.

Close This Message

CREATE AN ACCOUNT

Name:
Username:
Password:
Verify Password:
E-mail:
Verify E-mail:
*All Fields Are Required.
Please Verify You Are Human:
fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Edlich-Muth, C; Artero, JB; Callow, P; Przewloka, MR; Watson, AA; Zhang, W; Glover, DM; Debski, J; Dadlez, M; Round, AR; Forsyth, VT; Laue, ED (2015)
Publisher: Elsevier
Journal: Journal of Molecular Biology
Languages: English
Types: Article
Subjects: Molecular Biology, Q1, NOE, nuclear Overhauser enhancement, structure determination, histone chaperone, Article, NMR, nucleoplasmin, SAXS, small-angle X-ray scattering, HSQC, heteronuclear single quantum coherence, SANS, small-angle neutron scattering, FKBP, PPI, peptidyl proline isomerase

Classified by OpenAIRE into

mesheuropmc: urogenital system, fungi, lipids (amino acids, peptides, and proteins)
Nucleoplasmin is a histone chaperone that consists of a pentameric N-terminal domain and an unstructured C-terminal tail. The pentameric core domain, a doughnut-like structure with a central pore, is only found in the nucleoplasmin family. Here, we report the first structure of a nucleoplasmin-like domain (NPL) from the unrelated Drosophila protein, FKBP39, and we present evidence that this protein associates with chromatin. Furthermore, we show that two other chromatin proteins, Arabidopsis thaliana histone deacetylase type 2 (HD2) and Saccharomyces cerevisiae Fpr4, share the NPL fold and form pentamers, or a dimer of pentamers in the case of HD2. Thus, we propose a new family of proteins that share the pentameric nucleoplasmin-like NPL domain and are found in protists, fungi, plants and animals.

Share - Bookmark

Funded by projects

Cite this article