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- 1. Kwak B, Mulhaupt F, Myit S, Mach F. Statins as a newly recognized type of immunomodulator. Nat Med 2000;6:1399-402.
- 2. Lawman S, Mauri C, Jury EC, Cook HT, Ehrenstein MR. Atorevidence suggest that the inhibition of cholesterol vastatin inhibits autoreactive B cell activation and delays lupus develsynthesis by statins disrupts these lipid rafts and 7o6p4m1e-n6t. in New Zealand black/white F1 mice. J Immunol 2004;173: thereby influences the function of lymphocytes 3. Aprahamian T, Rifkin I, Bonegio R, et al. Impaired clearance of (Fig. 1). apoptotic cells promotes synergy between atherogenesis and autoCould all the immunomodulation by statins be i4m.mNuinsesednisSeEas,eT.uJzEcxupEMMe,dS2c0h0o4e;n1h9a9g:1e1n2P1,-3et1.al. Effects of statin ascribed to their ability to reduce cholesterol levels therapy on LDL cholesterol, C-reactive protein, and the progresin the cell membrane? Serum and membrane cho- sion of coronary artery disease. N Engl J Med 2005;352:29-38. lesterol may be differentially affected by statin treat- 5C.-reRacidtikveerpPrMot,eCina nlenvoenlsCaPft,eMrostrartoiwn tDh,eeratpayl.. CNliEnnicgall JreMleevdan2c0e0o5f; ment, and only by assaying both could the full ef- 352:20-8. fects of statins be identified. Although the changes 6. del Real G, Jimenez-Baranda S, Mira E, et al. Statins inhibit in membrane cholesterol levels may be relevant only 2H0I0V:-514i1n-f7e.ction by down-regulating Rho activity. J Exp Med 2004; at sites of lymphocyte activation, as in atheroma or Copyright © 2005 Massachusetts Medical Society.
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