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Lockyer, Stacey; Rowland, Ian; Spencer, Jeremy Paul Edward; Yaqoob, Parveen; Stonehouse, Welma (2016)
Publisher: Springer Berlin Heidelberg
Journal: European Journal of Nutrition
Languages: English
Types: Article
Subjects: Polyphenols, Cardiovascular disease, Blood pressure, Olive leaf, Original Contribution, Oleuropein, Plasma lipids
Purpose Dietary polyphenols have been demonstrated to favourably modify a number of cardiovascular risk markers such as blood pressure (BP), endothelial function and plasma lipids. We conducted a randomised, double-blind, controlled, crossover trial to investigate the effects of a phenolic-rich olive leaf extract (OLE) on BP and a number of associated vascular and metabolic measures. Methods A total of 60 pre-hypertensive [systolic blood pressure (SBP): 121?140?mmHg; diastolic blood pressure (DBP): 81?90?mmHg] males [mean age 45 (?SD 12.7?years, BMI 26.7 (?3.21) kg/m2] consumed either OLE (136?mg oleuropein; 6?mg hydroxytyrosol) or a polyphenol-free control daily for 6?weeks before switching to the alternate arm after a 4-week washout. Results Daytime [?3.95 (?SD 11.48) mmHg, p?=?0.027] and 24-h SBP [?3.33 (?SD 10.81) mmHg, p?=?0.045] and daytime and 24-h DBP [?3.00 (?SD 8.54) mmHg, p?=?0.025; ?2.42 (?SD 7.61) mmHg, p?=?0.039] were all significantly lower following OLE intake, relative to the control. Reductions in plasma total cholesterol [?0.32 (?SD 0.70) mmol/L, p?=?0.002], LDL cholesterol [?0.19 (?SD 0.56) mmol/L, p?=?0.017] and triglycerides [?0.18 (?SD 0.48), p?=?0.008] were also induced by OLE compared to control, whilst a reduction in interleukin-8 [?0.63 (?SD 1.13) pg/ml; p?=?0.026] was also detected. Other markers of inflammation, vascular function and glucose metabolism were not affected. Conclusion Our data support previous research, suggesting that OLE intake engenders hypotensive and lipid-lowering effects in vivo. Electronic supplementary material The online version of this article (doi:10.1007/s00394-016-1188-y) contains supplementary material, which is available to authorized users.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

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