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fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Lee, Chi
Languages: English
Types: Doctoral thesis
Subjects: RK

Classified by OpenAIRE into

mesheuropmc: stomatognathic system, stomatognathic diseases
Dental pulp stem cells (DPSCs) play an integral role during dentine injury where they migrate towards the injury site, proliferate, differentiate into odontoblast-like\ud cells and secrete a mineralised matrix, protecting the vital pulp tissue and preserving the tooth organ. Dentine matrix proteins (DMP) may have a role in stimulating this\ud reparative dentine formation. Multiple adult stem cells make up the DPSC population. Within this study progenitor\ud cells were isolated from dental pulp by preferential fibronectin adherence (FNA) or using magnetic activated cell sorting (MACS) to isolate P75 expressing neural crest\ud cells. Clonally expanded colonies were established. The proliferative FNA and P75-sorted populations were shown to be distinct progenitors with differing morphology\ud and stem cell marker expression. One FNA clonal population was differentiated into mesenchymal lineages that established it as a multipotent DPSC population.\ud Clonal populations were supplemented with DMP in vitro to examine the potential role of DMP in modulating cell behaviour during dentine injury. Supplementing with\ud DMP had a dose dependent response on DPSC viability, increased cell numbers,reduced apoptosis and promoted cell migration, suggesting that the growth factors in\ud DMP may have a positive synergistic effect on DPSC behaviour. Fluorescently stained DPSCs were microinjected into transverse tooth slices and placed in culture to develop an ex vivo model to study DPSC behaviour in a tooth\ud environment. Injected cells remained viable after 7 days of culture, providing proof of concept data that DPSCs can be localised for study in situ. This thesis was successful in the isolation of clonal populations representing\ud progenitor cells with different characteristics. Supplementing DPSCs with DMP promoted cell behaviour facilitating reparative dentinogenesis, indicating a potential clinical application for DMP in restorative therapy. The study of DPSCs using the ex\ud vivo model will be important in further development of these novel therapies for dental tissue regeneration.
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    • Downer, M. C. 1993. Changing trends in dental caries experience in Great Britain. Adv Dent Res 7(1), pp. 19-24.
    • Dowthwaite, G. P. et al. 2004. The surface of articular cartilage contains a progenitor cell population. J Cell Sci 117(Pt 6), pp. 889-897.
    • Driessens, F. C. M. and Woltgens, J. H. M. 1986. Tooth Development and Caries. Florida, USA: CRC Press Inc.
    • Ducy, P. et al. 1996. Increased bone formation in osteocalcin-deficient mice. Nature 382(6590), pp. 448-452.
    • Dung, S. Z. et al. 1995. Effect of lactic acid and proteolytic enzymes on the release of organic matrix components from human root dentin. Caries Res 29(6), pp. 483-489.
    • Dupin, E. et al. 2007. Neural crest progenitors and stem cells. C R Biol 330(6-7), pp. 521-529.
    • Dupin, E. et al. 2000. Endothelin 3 induces the reversion of melanocytes to glia through a neural crest-derived glial-melanocytic progenitor. Proc Natl Acad Sci U S A 97(14), pp. 7882-7887.
    • Dupin, E. et al. 1998. The avian embryo as a model in developmental studies: chimeras and in vitro clonal analysis. Curr Top Dev Biol 36, pp. 1-35.
    • Duque, C. et al. 2006. Reactionary dentinogenesis after applying restorative materials and bioactive dentin matrix molecules as liners in deep cavities prepared in nonhuman primate teeth. J Oral Rehabil 33(6), pp. 452-461.
    • Echelard, Y. et al. 1994. Cis-acting regulatory sequences governing Wnt-1 expression in the developing mouse CNS. Development 120(8), pp. 2213-2224.
    • Embery, G. et al. 2001. Proteoglycans in dentinogenesis. Crit Rev Oral Biol Med 12(4), pp. 331-349.
    • Eriksen, H. M. 1998. Has caries merely been postponed? Acta Odontol Scand 56(3), pp. 173-175.
    • Evans, M. J. and Kaufman, M. H. 1981. Establishment in culture of pluripotential cells from mouse embryos. Nature 292(5819), pp. 154-156.
    • Fang, J. et al. 2009. Changes of the unique odontogenic properties of rat apical bud cells under the developing apical complex microenvironment. Int J Oral Sci 1(1), pp. 26-33.
    • Farrington-Rock, C. et al. 2004. Chondrogenic and adipogenic potential of microvascular pericytes. Circulation 110(15), pp. 2226-2232.
    • Fellenberg, J. et al. 2010. Overexpression of inosine 5'-monophosphate dehydrogenase type II mediates chemoresistance to human osteosarcoma cells. PLoS One 5(8), p. e12179.
    • Ferrari, G. et al. 1998. Muscle regeneration by bone marrow-derived myogenic progenitors. Science 279(5356), pp. 1528-1530.
    • Finkelman, R. D. et al. 1990. Quantitation of growth factors IGF-I, SGF/IGF-II, and TGF-beta in human dentin. J Bone Miner Res 5(7), pp. 717-723.
    • Fitzgerald, M. et al. 1990. Autoradiographic analysis of odontoblast replacement following pulp exposure in primate teeth. Arch Oral Biol 35(9), pp. 707-715.
    • Flores, I. et al. 2006. Telomerase regulation and stem cell behaviour. Curr Opin Cell Biol 18(3), pp. 254-260.
    • Foreman, P. C. 1988. Fluorescent microstructure of mineralized dental tissues. Int Endod J 21(4), pp. 251-256.
    • Fuchs, E. and Segre, J. A. 2000. Stem cells: a new lease on life. Cell 100(1), pp. 143- 155.
    • Fuchs, E. et al. 2004. Socializing with the neighbors: stem cells and their niche. Cell 116(6), pp. 769-778.
    • Fujii, S. et al. 2008. Investigating a clonal human periodontal ligament progenitor/stem cell line in vitro and in vivo. J Cell Physiol 215(3), pp. 743-749.
    • Gallato, A. et al. 2005. Long-term monitoring of microleakage of different amalgams with different liners. J Prosthet Dent 93(6), pp. 571-576.
    • Gang, E. J. et al. 2007. SSEA-4 identifies mesenchymal stem cells from bone marrow. Blood 109(4), pp. 1743-1751.
    • Gao, X. and Nie, S. 2003. Molecular profiling of single cells and tissue specimens with quantum dots. Trends Biotechnol 21(9), pp. 371-373.
    • Gatto, M. et al. 2008. Insulin-like growth factor-1 isoforms in rat hepatocytes and cholangiocytes and their involvement in protection against cholestatic injury. Lab Invest 88(9), pp. 986-994.
    • Gay, I. C. et al. 2007. Isolation and characterization of multipotent human periodontal ligament stem cells. Orthod Craniofac Res 10(3), pp. 149-160.
    • Geiger, H. et al. 1998. Globin gene expression is reprogrammed in chimeras generated by injecting adult hematopoietic stem cells into mouse blastocysts. Cell 93(6), pp. 1055-1065.
    • George, A. et al. 1994. In situ localization and chromosomal mapping of the AG1 (Dmp1) gene. J Histochem Cytochem 42(12), pp. 1527-1531.
    • Gerashchenko, B. I. 2011. Choosing a cell sorting option to study the fate of bystander cells: FACS or MACS? Cytometry A.
    • Godovikova, V. and Ritchie, H. H. 2007. Dynamic processing of recombinant dentin sialoprotein-phosphophoryn protein. J Biol Chem 282(43), pp. 31341-31348.
    • Goldberg, M. and Lasfargues, J. J. 1995. Pulpo-dentinal complex revisited. J Dent 23(1), pp. 15-20.
    • Goldberg, M. et al. 2003. Immunohistochemical localization of MMP-2, MMP-9, TIMP-1, and TIMP-2 in the forming rat incisor. Connect Tissue Res 44(3-4), pp. 143-153.
    • Goldberg, M. et al. 2009. Dentin extracellular matrix molecules implanted into exposed pulps generate reparative dentin: a novel strategy in regenerative dentistry. J Dent Res 88(5), pp. 396-399.
    • Gonzales, M. et al. 2001. Structure and function of a vimentin-associated matrix adhesion in endothelial cells. Mol Biol Cell 12(1), pp. 85-100.
    • Gorter de Vries, I. et al. 1987. Immunocytochemical localization of osteocalcin in developing rat teeth. J Dent Res 66(3), pp. 784-790.
    • Gould, T. R. et al. 1980. Migration and division of progenitor cell populations in periodontal ligament after wounding. J Periodontal Res 15(1), pp. 20-42.
    • Graham, A. 2003. The neural crest. Curr Biol 13(10), pp. R381-384.
    • Graham, L. et al. 2006. The effect of calcium hydroxide on solubilisation of bioactive dentine matrix components. Biomaterials 27(14), pp. 2865-2873.
    • Grando Mattuella, L. et al. 2007. Vascular endothelial growth factor and its relationship with the dental pulp. J Endod 33(5), pp. 524-530.
    • Gronthos, S. et al. 2002. Stem cell properties of human dental pulp stem cells. J Dent Res 81(8), pp. 531-535.
    • Gronthos, S. et al. 2000. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A 97(25), pp. 13625-13630.
    • Gronthos, S. and Zannettino, A. C. 2008. A method to isolate and purify human bone marrow stromal stem cells. Methods Mol Biol 449, pp. 45-57.
    • Grottkau, B. E. et al. 2010. Multilineage differentiation of dental pulp stem cells from green fluorescent protein transgenic mice. Int J Oral Sci 2(1), pp. 21-27.
    • Guimarães, E. T. et al. 2011. Mesenchymal and embryonic characteristics of stem cells obtained from mouse dental pulp. Arch Oral Biol.
    • Hahn, C. L. et al. 1989. A study of T and B cells in pulpal pathosis. J Endod 15(1), pp. 20-26.
    • Harada, H. et al. 1999. Localization of putative stem cells in dental epithelium and their association with Notch and FGF signaling. J Cell Biol 147(1), pp. 105-120.
    • Hascall, V. C. and Sajdera, S. W. 1970. Physical properties and polydispersity of proteoglycan from bovine nasal cartilage. J Biol Chem 245(19), pp. 4920-4930.
    • Hasegawa, N. 1989. Effects of various culture conditions on matrix formative functions of rat incisor odontoblasts in a pulp-dentin slice culture system. Shika Kiso Igakkai Zasshi 31(4), pp. 392-403.
    • He, G. et al. 2003. Dentin matrix protein 1 initiates hydroxyapatite formation in vitro. Connect Tissue Res 44 Suppl 1, pp. 240-245.
    • He, W. X. et al. 2005. Smad protein mediated transforming growth factor beta1 induction of apoptosis in the MDPC-23 odontoblast-like cell line. Arch Oral Biol 50(11), pp. 929-936.
    • Henion, P. D. and Weston, J. A. 1997. Timing and pattern of cell fate restrictions in the neural crest lineage. Development 124(21), pp. 4351-4359.
    • Horst, O. V. et al. 2009. TGF-beta1 Inhibits TLR-mediated odontoblast responses to oral bacteria. J Dent Res 88(4), pp. 333-338.
    • Hu, G. et al. 2011. Supernatant of bone marrow mesenchymal stromal cells induces peripheral blood mononuclear cells possessing mesenchymal features. Int J Biol Sci 7(3), pp. 364-375.
    • Huang, A. H. et al. 2009a. Isolation and characterization of human dental pulp stem/stromal cells from nonextracted crown-fractured teeth requiring root canal therapy. J Endod 35(5), pp. 673-681.
    • Huang, G. T. et al. 2009b. Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine. J Dent Res 88(9), pp. 792-806.
    • Huang, G. T. et al. 2008. The hidden treasure in apical papilla: the potential role in pulp/dentin regeneration and bioroot engineering. J Endod 34(6), pp. 645-651.
    • Huang, X. P. et al. 2010. Differentiation of allogeneic mesenchymal stem cells induces immunogenicity and limits their long-term benefits for myocardial repair. Circulation 122(23), pp. 2419-2429.
    • Hung, C. N. et al. 2011a. A comparison between adipose tissue and dental pulp as sources of MSCs for tooth regeneration. Biomaterials 32(29), pp. 6995-7005.
    • Hung, S. P. et al. 2011b. Hypoxia promotes proliferation and osteogenic differentiation potentials of human mesenchymal stem cells. J Orthop Res.
    • Hynes, R. O. 1992. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69(1), pp. 11-25.
    • Ikeda, H. et al. 2010. Engineering Bone Formation from Human Dental Pulp- and Periodontal Ligament-Derived Cells. Ann Biomed Eng.
    • Iohara, K. et al. 2004. Dentin regeneration by dental pulp stem cell therapy with recombinant human bone morphogenetic protein 2. J Dent Res 83(8), pp. 590- 595.
    • Iohara, K. et al. 2009. Regeneration of dental pulp after pulpotomy by transplantation of CD31(-)/CD146(-) side population cells from a canine tooth. Regen Med 4(3), pp. 377-385.
    • Iohara, K. et al. 2006. Side population cells isolated from porcine dental pulp tissue with self-renewal and multipotency for dentinogenesis, chondrogenesis, adipogenesis, and neurogenesis. Stem Cells 24(11), pp. 2493-2503.
    • Itota, T. et al. 2001. Alteration of odontoblast osteonectin expression following dental cavity preparation. Arch Oral Biol 46(9), pp. 829-834.
    • Izumi, T. et al. 1995. Immunohistochemical study on the immunocompetent cells of the pulp in human non-carious and carious teeth. Arch Oral Biol 40(7), pp. 609- 614.
    • Jäger, M. et al. 2008. Dexamethasone modulates BMP-2 effects on mesenchymal stem cells in vitro. J Orthop Res 26(11), pp. 1440-1448.
    • Jaiswal, J. K. et al. 2003. Long-term multiple color imaging of live cells using quantum dot bioconjugates. Nat Biotechnol 21(1), pp. 47-51.
    • Jaiswal, J. K. and Simon, S. M. 2004. Potentials and pitfalls of fluorescent quantum dots for biological imaging. Trends Cell Biol 14(9), pp. 497-504.
    • Javelet, J. et al. 1985. Comparison of two pH levels for the induction of apical barriers in immature teeth of monkeys. J Endod 11(9), pp. 375-378.
    • Jernvall, J. and Thesleff, I. 2000. Reiterative signaling and patterning during mammalian tooth morphogenesis. Mech Dev 92(1), pp. 19-29.
    • Johnstone, B. et al. 1998. In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res 238(1), pp. 265-272.
    • Jones, E. A. et al. 2002. Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells. Arthritis Rheum 46(12), pp. 3349-3360.
    • Jones, P. H. and Watt, F. M. 1993. Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell 73(4), pp. 713-724.
    • Kadar, K. et al. 2009. Differentiation potential of stem cells from human dental origin - promise for tissue engineering. J Physiol Pharmacol 60 Suppl 7, pp. 167-175.
    • Kahler, B. et al. 2003. Fracture-toughening mechanisms responsible for differences in work to fracture of hydrated and dehydrated dentine. J Biomech 36(2), pp. 229-237.
    • Kardos, T. B. et al. 1998. Odontoblast differentiation: a response to environmental calcium? Endod Dent Traumatol 14(3), pp. 105-111.
    • Kitamura, H. et al. 1992. Color Atlas of Human Oral Histology. St Louis and Tokyo: Ishiyaku EuroAmerica Inc.
    • Kolf, C. M. et al. 2007. Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation. Arthritis Res Ther 9(1), p. 204.
    • Kota, B. P. et al. 2005. An overview on biological mechanisms of PPARs. Pharmacol Res 51(2), pp. 85-94.
    • Kotobuki, N. et al. 2004. Enhancement of in vitro osteoblastic potential after selective sorting of osteoblasts with high alkaline phosphatase activity from human osteoblast-like cells. Cell Transplant 13(4), pp. 377-383.
    • Lacerda-Pinheiro, S. et al. 2008. An In vivo Model for Short-Term Evaluation of the Implantation Effects of Biomolecules or Stem Cells in the Dental Pulp. Open Dent J 2, pp. 67-72.
    • Laino, G. et al. 2006. An approachable human adult stem cell source for hard-tissue engineering. J Cell Physiol 206(3), pp. 693-701.
    • Le Douarin, N. M. and Dupin, E. 2003. Multipotentiality of the neural crest. Curr Opin Genet Dev 13(5), pp. 529-536.
    • Lee, J. et al. 2006. The human OCT-4 isoforms differ in their ability to confer selfrenewal. J Biol Chem 281(44), pp. 33554-33565.
    • Lei, G. et al. 2011. Dentinogenic capacity: immature root papilla stem cells versus mature root pulp stem cells. Biol Cell 103(4), pp. 185-196.
    • Lesot, H. et al. 1986. Cell-matrix interactions: influence of noncollagenous proteins from dentin on cultured dental cells. J Embryol Exp Morphol 96, pp. 195-209.
    • Levin, L. G. et al. 1999. Expression of IL-8 by cells of the odontoblast layer in vitro. Eur J Oral Sci 107(2), pp. 131-137.
    • Li, L. and Xie, T. 2005. Stem cell niche: structure and function. Annu Rev Cell Dev Biol 21, pp. 605-631.
    • Li, M. et al. 2010. A novel function for vimentin: the potential biomarker for predicting melanoma hematogenous metastasis. J Exp Clin Cancer Res 29, p. 109.
    • Liao, S. M. 2005. Rescuing human embryonic stem cell research: the Blastocyst Transfer Method. Am J Bioeth 5(6), pp. 8-16.
    • Lin, P. Y. et al. 2010. Imaging carious dental tissues with multiphoton fluorescence lifetime imaging microscopy. Biomed Opt Express 2(1), pp. 149-158.
    • Linde, A. and Goldberg, M. 1993. Dentinogenesis. Crit Rev Oral Biol Med 4(5), pp. 679-728.
    • Liu, P. et al. 1999. Requirement for Wnt3 in vertebrate axis formation. Nat Genet 22(4), pp. 361-365.
    • Liu, X. and Ma, P. X. 2004. Polymeric scaffolds for bone tissue engineering. Ann Biomed Eng 32(3), pp. 477-486.
    • Liu, X. and Ma, P. X. 2009. Phase separation, pore structure, and properties of nanofibrous gelatin scaffolds. Biomaterials 30(25), pp. 4094-4103.
    • Liu, Y. et al. 1998a. Inosine-5'-monophosphate dehydrogenase is a rate-determining factor for p53-dependent growth regulation. Mol Biol Cell 9(1), pp. 15-28.
    • Liu, Y. et al. 1998b. Comparison of bax, waf1, and IMP dehydrogenase regulation in response to wild-type p53 expression under normal growth conditions. J Cell Physiol 177(2), pp. 364-376.
    • Lovschall, H. et al. 2001. Pulp-capping with recombinant human insulin-like growth factor I (rhIGF-I) in rat molars. Adv Dent Res 15, pp. 108-112.
    • Lovschall, H. et al. 2005. Activation of the Notch signaling pathway in response to pulp capping of rat molars. Eur J Oral Sci 113(4), pp. 312-317.
    • Ma, D. et al. 2009. Effect of age and extrinsic microenvironment on the proliferation and osteogenic differentiation of rat dental pulp stem cells in vitro. J Endod 35(11), pp. 1546-1553.
    • McGonnell, I. M. and Graham, A. 2002. Trunk neural crest has skeletogenic potential. Curr Biol 12(9), pp. 767-771.
    • Meissner, A. et al. 2007. Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat Biotechnol 25(10), pp. 1177-1181.
    • Messier, B. and Leblond, C. P. 1960. Cell proliferation and migration as revealed by radioautography after injection of thymidine-H3 into male rats and mice. Am J Anat 106, pp. 247-285.
    • Metcalf, D. 2003. The unsolved enigmas of leukemia inhibitory factor. Stem Cells 21(1), pp. 5-14.
    • Milan, A. M. et al. 2004. Dentinal proteoglycans demonstrate an increasing order of affinity for hydroxyapatite crystals during the transition of predentine to dentine. Calcif Tissue Int 75(3), pp. 197-204.
    • Milan, A. M. et al. 2005. Modulation of collagen fibrillogenesis by dentinal proteoglycans. Calcif Tissue Int 76(2), pp. 127-135.
    • Mimeault, M. and Batra, S. K. 2006. Concise review: recent advances on the significance of stem cells in tissue regeneration and cancer therapies. Stem Cells 24(11), pp. 2319-2345.
    • Mitsiadis, T. A. et al. 1999. Reactivation of Delta-Notch signaling after injury: complementary expression patterns of ligand and receptor in dental pulp. Exp Cell Res 246(2), pp. 312-318.
    • Mitsiadis, T. A. et al. 2003. Notch2 protein distribution in human teeth under normal and pathological conditions. Exp Cell Res 282(2), pp. 101-109.
    • Miura, M. et al. 2003. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci U S A 100(10), pp. 5807-5812.
    • Morrison, S. J. et al. 1996. Telomerase activity in hematopoietic cells is associated with self-renewal potential. Immunity 5(3), pp. 207-216.
    • Murakami, Y. et al. 2003. Novel isolation of alkaline phosphatase-positive subpopulation from periodontal ligament fibroblasts. J Periodontol 74(6), pp. 780-786.
    • Murray, J. J. 2011. Adult Dental Health Surveys: 40 years on. Br Dent J 211(9), pp. 407-408.
    • Murray, P. E. et al. 2002. Hierarchy of variables correlated to odontoblast-like cell numbers following pulp capping. J Dent 30(7-8), pp. 297-304.
    • Murray, P. E. et al. 2000. Tooth slice organ culture for cytotoxicity assessment of dental materials. Biomaterials 21(16), pp. 1711-1721.
    • Mutoh, N. et al. 2009. Expression of Toll-like receptor 2 and 4 in inflamed pulp in severe combined immunodeficiency mice. J Endod 35(7), pp. 975-980.
    • Nakao, K. et al. 2004. FGF-2 potently induces both proliferation and DSP expression in collagen type I gel cultures of adult incisor immature pulp cells. Biochem Biophys Res Commun 325(3), pp. 1052-1059.
    • Nishikawa, S. and Osawa, M. 2007. Generating quiescent stem cells. Pigment Cell Res 20(4), pp. 263-270.
    • Niswander, L. 2002. Interplay between the molecular signals that control vertebrate limb development. Int J Dev Biol 46(7), pp. 877-881.
    • Niyibizi, C. and Eyre, D. R. 1994. Structural characteristics of cross-linking sites in type V collagen of bone. Chain specificities and heterotypic links to type I collagen. Eur J Biochem 224(3), pp. 943-950.
    • Ofek, G. et al. 2008. Matrix development in self-assembly of articular cartilage. PLoS One 3(7), p. e2795.
    • Ohshima, H. et al. 2005. The eternal tooth germ is formed at the apical end of continuously growing teeth. Arch Oral Biol 50(2), pp. 153-157.
    • Oswald, F. et al. 2001. p300 acts as a transcriptional coactivator for mammalian Notch-1. Mol Cell Biol 21(22), pp. 7761-7774.
    • Pashley, D. H. 1996. Dynamics of the pulpo-dentin complex. Crit Rev Oral Biol Med 7(2), pp. 104-133.
    • Patel, M. et al. 2009. Phenotype and behaviour of dental pulp cells during expansion culture. Arch Oral Biol 54(10), pp. 898-908.
    • Pääkkönen, V. et al. 2007. Effects of TGF-beta 1 on interleukin profile of human dental pulp and odontoblasts. Cytokine 40(1), pp. 44-51.
    • Qin, C. et al. 2006. A chondroitin sulfate chain attached to the bone dentin matrix protein 1 NH2-terminal fragment. J Biol Chem 281(12), pp. 8034-8040.
    • Sadaghiani, L. et al. Effects of Adhesive Restorative Agents on Solubilising Dentine Matrix Proteins. In: IADR/AADR 88th General Session. Barcelona, Spain. J Dent Res 89 (Spec Iss B): 2957. 2010. (www.dentalresearch.org).
    • Scadden, D. T. 2006. The stem-cell niche as an entity of action. Nature 441(7097), pp. 1075-1079.
    • Schwab, K. E. and Gargett, C. E. 2007. Co-expression of two perivascular cell markers isolates mesenchymal stem-like cells from human endometrium. Hum Reprod 22(11), pp. 2903-2911.
    • Seo, B. M. et al. 2004. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 364(9429), pp. 149-155.
    • Sherley, J. L. 2002. Asymmetric cell kinetics genes: the key to expansion of adult stem cells in culture. Stem Cells 20(6), pp. 561-572.
    • Sloan, A. J. and Smith, A. J. 2007. Stem cells and the dental pulp: potential roles in dentine regeneration and repair. Oral Dis 13(2), pp. 151-157.
    • Sloan, A. J. and Waddington, R. J. 2009. Dental pulp stem cells: what, where, how? Int J Paediatr Dent 19(1), pp. 61-70.
    • Smith, A. J. et al. 1995. Reactionary dentinogenesis. Int J Dev Biol 39(1), pp. 273- 280.
    • Smith, A. J. and Lesot, H. 2001. Induction and regulation of crown dentinogenesis: embryonic events as a template for dental tissue repair? Crit Rev Oral Biol Med 12(5), pp. 425-437.
    • Smith, A. J. et al. 2005. Dentine regeneration: key roles for stem cells and molecular signalling. Oral Biosciences Medicine 2(2/3), pp. 127-132.
    • Smith, A. J. et al. 1998. Transforming growth factor-beta1 (TGF-beta1) in dentine matrix. Ligand activation and receptor expression. Eur J Oral Sci 106 Suppl 1, pp. 179-184.
    • Smith, A. J. et al. 1994. Odontoblast stimulation in ferrets by dentine matrix components. Arch Oral Biol 39(1), pp. 13-22.
    • Smith, A. J. et al. 1990. In vivo morphogenetic activity of dentine matrix proteins. J Biol Buccale 18(2), pp. 123-129.
    • Smith, C. E. and Warshawsky, H. 1976. Movement of entire cell populations during renewal of the rat incisor as shown by radoioautography after labeling with 3Hthymidine. The concept of a continuously differentiating cross-sectional segment. (With an appendix on the development of the periodontal ligament). Am J Anat 145(2), pp. 225-259.
    • Smith, E. L. et al. 2010. An ex vivo rodent mandible culture model for bone repair. Tissue Eng Part C Methods 16(6), pp. 1287-1296.
    • Stanulis-Praeger, B. M. 1987. Cellular senescence revisited: a review. Mech Ageing Dev 38(1), pp. 1-48.
    • Stefanovic, S. et al. 2009. Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate. J Cell Biol 186(5), pp. 665-673.
    • Tucker, A. S. et al. 1998. Interactions between Bmp-4 and Msx-1 act to restrict gene expression to odontogenic mesenchyme. Dev Dyn 212(4), pp. 533-539.
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