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Balasubramani, L.; Brown, B.H.; Healey, J.; Tidy, J.A. (2009)
Publisher: Elsevier
Languages: English
Types: Article
Objective. To evaluate the efficacy of an electrical impedance probe (Epitheliometer) in the diagnosis of high grade cervical intraepithelial neoplasia (CIN) in women referred with cervical smear abnormalities and to assess the effect of acetic acid (AA) and tissue boundaries on the measurements.\ud \ud Methods. A prospective observational study was undertaken in the colposcopy clinic. One hundred and sixty-five women, either with a clinical indication or abnormal cervical cytology, were recruited into the study. A pencil type probe was used to record impedance spectra from 12 points on the cervix before and after the application of 5% AA. Spectra were also recorded from tissue boundaries. Colposcopic examinations, including probe positioning, were video recorded to allow for correlations between histopathological diagnosis of colposcopically directed biopsies, colposcopic impression and the diagnosis based on impedance measurements.\ud \ud Results. Receiver operating characteristic (ROC) curves were derived. The areas under the curves (AUCs) to discriminate original squamous from high grade CIN were 0.80 (pre AA) and 0.79 (post AA). Comparison of these curves showed no significant difference, indicating that application of AA does not produce a large change in spectra. The probe Could distinguish tissue boundaries from homogeneous tissue points.\ud \ud Conclusion. The Epitheliometer has the potential to be used as an adjunct to colposcopy in the diagnosis of high grade CIN. It has the advantage of real time results, decreasing the need for diagnostic cervical biopsies, and facilitates a wider use of the 'see and treat' policy without the risk of overtreatment. (C) 2009 Elsevier Inc. All rights reserved.\ud
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 1. Quinn M, Babb P, Jones J, Allen E. Effect of screening on incidence of and mortality from cancer of cervix in England: evaluation based on routinely collected statistics. Br Med J (Clinical research ed). 1999 Apr 3;318(7188):904-8.
    • 2. Nanda K, McCrory DC, Myers ER, Bastian LA, Hasselblad V, Hickey JD, et al. Accuracy of the Papanicolaou test in screening for and follow-up of cervical cytologic abnormalities: a systematic review. Annals Int Med. 2000 May 16;132(10):810-9.
    • 3. Arbyn M, Bergeron C, Klinkhamer P, Martin-Hirsch P, Siebers AG, Bulten J. Liquid Compared With Conventional Cervical Cytology: A Systematic Review and Metaanalysis. Obstet Gynecol. 2008 Jan;111(1):167-77.
    • 4. Louwers JA, Kocken M, ter Harmsel WA Verheijen RHM. Digital colposcopy:ready for use? An overview of literature. Br J Obstet Gynaecol 2009; 116:220-29
    • 5. Wang SS, Walker JL, Schiffman M, Solomon D. Evaluating the risk of cervical precancer with a combination of cytologic, virologic, and visual methods. Cancer Epidemiol Biomarkers Prev. 2005 Nov;14(11 Pt 1):2665-8.
    • 6. Walker DC, Brown BH, Blackett AD, Tidy J, Smallwood RH. A study of the morphological parameters of cervical squamous epithelium. Physiological measurement. 2003 Feb;24(1):121-35.
    • 7. Walker DC, Brown BH, Smallwood RH, Hose DR, Jones DM. Modelled current distribution in cervical squamous tissue. Physiol Meas. 2002 Feb;23(1):159-68.
    • 8. Brown BH, Tidy JA, Boston K, Blackett AD, Smallwood RH, Sharp F. Relation between tissue structure and imposed electrical current flow in cervical neoplasia. Lancet. 2000 Mar 11;355(9207):892-5.
    • 9. Brown BH, Milnes P, Abdul S, Tidy JA. Detection of cervical intraepithelial neoplasia using impedance spectroscopy: a prospective study Br J Obstet Gynaecol. 2005 Jun;112(6):802-6.
    • 10. Abdul S, Brown BH, Milnes P, Tidy JA. The use of electrical impedance spectroscopy in the detection of cervical intraepithelial neoplasia. Int J Gynecol Cancer. 2006 Sep-Oct;16(5):1823-32.
    • 12. Gonzalez-Correa CA, Brown BH, Smallwood RH, Walker DC, Bardhan KD. Electrical bioimpedance readings increase with higher pressure applied to the measuring probe. Physiological measurement. 2005 Apr;26(2):S39-47.
    • 13. Balas C PG, Potirakis A. in Vivo molecular imaging of cervical neoplasia using acetic acid as biomarker. IEEE Journal of selected topics in quantum electronics. 2008;14:29-42.
    • 14. White FH, Gohari K. Alterations in the volume of the intercellular space between epithelial cells of the hamster cheek-pouch: quantitative studies of normal and carcinogen-treated tissues. J Oral Pathol. 1984 Jun;13(3):244-54.
    • 15. Abdul S, Brown BH, Milnes P, Tidy JA. A clinical study of the use of impedance spectroscopy in the detection of cervical intraepithelial neoplasia (CIN). Gynecol Oncol. 2005 Dec;99(3 Suppl 1):S64-6.
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