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Mohammed, Khalfan A; Deb, Rinki M; Stanton, Michelle C; Molyneux, David H (2012)
Publisher: BioMed Central
Journal: Parasites & Vectors
Languages: English
Types: Article
Subjects: qx_200, qx_475, d67ea616, qx_20, Infectious Diseases, wa_395, wc_900, wc_885, wr_365, Research, wc_880, RC109-216, wx_173, Infectious and parasitic diseases, Parasitology

Classified by OpenAIRE into

mesheuropmc: parasitic diseases



Ivermectin and albendazole are used in annual mass drug administration (MDA) for the lymphatic filariasis elimination programmes in African countries co-endemic for onchocerciasis, but have additional impact on soil transmitted helminths and the ectoparasitic mite which causes scabies. Assessing these collateral impacts at scale is difficult due to the insensitivity of available parasite detection techniques.


The numbers of cases diagnosed with intestinal helminths and scabies and who received prescriptions for treatment were evaluated in 50 health centres in Zanzibar. Records were examined from 2000, prior to the initiation of MDA to 2005, after six rounds of MDA for lymphatic filariasis had taken place.


Health centre records showed a consistent decline in the number of cases of intestinal helminths and scabies diagnosed by community health workers in Zanzibar and the number of prescriptions issued across five age groups. A 90-98% decline in soil transmitted helminths and 68-98% decline in scabies infections were recorded. Poisson regression models aggregated to both the island-level and district-level indicated that the decline was statistically significant.


The described method of examining health centre records has the potential for use on a large scale, despite limitations, as a rapid method to evaluate the impacts resulting from both lymphatic filariasis and onchocerciasis MDA. This would result in a reduction in the need for parasitological evaluations to determine prevalence and intensity.

  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

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    The results below are discovered through our pilot algorithms. Let us know how we are doing!

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