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fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Publisher: BioMed Central
Journal: Reproductive Biology and Endocrinology : RB&E
Languages: English
Types: Article
Subjects: In vitro fertilization (IVF), Diminished ovarian reserve (DOR), Review, Poor ovarian response, Dehydroepiandrosterone (DHEA)

Classified by OpenAIRE into

mesheuropmc: hormones, hormone substitutes, and hormone antagonists, endocrine system
Women with diminished ovarian reserve often respond poorly to controlled ovarian stimulation resulting in retrieval of fewer oocytes and reduced pregnancy rates. It has been proposed that pre-IVF Dehydroepiandrosterone (DHEA) adjuvant therapy may improve ovarian response and pregnancy rates in women with diminished ovarian reserve. This meta-analysis aims to investigate efficacy of DHEA as an adjuvant to improve ovarian response and IVF outcome in women with diminished ovarian reserve. Electronic databases were searched under the following terms: (DHEA) and (diminished ovarian reserve) and/or (poor response). Studies were included if they reported at least one of the following outcomes; clinical pregnancy rate, number of oocytes retrieved, miscarriage rate. We identified 22 publications determining effects of DHEA in clinical trials. Only 3 controlled studies were eligible for meta-analysis. There was no significant difference in the clinical pregnancy rate and miscarriage rates between women pre-treated with DHEA compared to those without DHEA pre-treatment (RR 1.87, 95% CI 0.96-3.64; and RR 0.59, 95% CI 0.21-1.65, respectively). The number of oocytes retrieved (WMD -1.88, 95% CI -2.08, 1.67; P?
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

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