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fbtwitterlinkedinvimeoflicker grey 14rssslideshare1
Languages: English
Types: Doctoral thesis
Subjects: RE
The outcome of higher order aberrations (HOAs) prior to, and following, age-related cataract extraction and intra-ocular lens (IOL) implantation was explored using placido disc skiaoscopy aberrometry. Ninety-nine individuals (median age 73.0, IQR 67.0, 80.5) underwent comprehensive ophthalmic examination including contrast sensitivity, endothelial cell imaging and aberrometry (Nidek OPD ARK-10000) at approximately 4 weeks pre-operatively (median 3.9, IQR 2.9, 4.8) 10 weeks (median 7.1, IQR 5.64, 11.71) (67 individuals) and 80 weeks (median 85.1, IQR 80.0, 89.6) (41 individuals) post-operatively. Linear relationships between thirteen demographical, functional and structural variables and each of three components, Total (TC), Corneal (CC) and Internal (IC), for each of eight HOAs, were separately explored, using Analysis of Variance, for each examination and for the pre- and post-operative differences, respectively. The TC and IC of all HOAs decreased post-operatively (p≤68%). Preoperatively, the TC and IC of the Total HOA decreased as the spherical equivalent (SE) became less negative (both p<0.001, R2=0.56 and 0.53). Both components of the Total HOA also decreased as the difference in SE between baseline and each follow-up became less negative (all p≤0.008, R2=0.45-0.61); the magnitude of the reduction varied between IOL type (p≤0.008). The IC of the Tilt, T.Sph and HiAstig HOAs increased with increase in severity of posterior subcapsular (p=0.018), of cortical (p=0.013) and of combined nuclear colour and cortical cataract (p=0.003), respectively. The relationship between cataract type and severity and reduction in post-operative HOA was not statistically significant at either follow-up examination. Slight associations, presumably due to post-operative corneal oedema, were present between increase in CCs of five HOAs and decreasing endothelial cell density at the first follow-up, only, (all p≤0.030, R2=0.09-0.14). Pre-operative TCs and ICs were larger, respectively, than those of 22 individuals with ‘less severe’ cataract and post-operatively than those of 49 individuals with clear media, obtained from retrospective data.
  • The results below are discovered through our pilot algorithms. Let us know how we are doing!

    • 3.5.1.12.1 Total Component of the Total HOA 122
    • 3.5.1.12.2 Total Component of the Tilt (S1) HOA 123
    • 3.5.1.12.3 Total Component of the High HOA 124
    • 3.5.1.12.4 Total Component of the T.Coma HOA 125
    • 3.5.1.12.5 Total Component of the T.Trefoil HOA 126
    • 3.5.1.12.6 Total Component of the T.4Foil HOA 127
    • 3.5.1.12.7 Total Component of the T.Sph HOA 128
    • 3.5.1.12.8 Total Component of the HiAstig HOA 129 3.5.2 Explanatory Analysis of Associations between the 130
    • 3.5.2.1 Age and Gender 131
    • 3.5.2.2 Distance Visual Acuity 133
    • 3.5.2.3 Near Visual Acuity 133
    • 3.5.2.4 Contrast Sensitivity 133
    • 3.5.2.5 Dilated Pupil Diameter 138
    • 3.5.2.6 Mean Corneal Curvature 138
    • 3.5.2.7 Flattest Corneal Curvature 140
    • 3.5.2.8 Corneal Endothelial Cell Density 140
    • 3.5.2.9 Spherical Equivalent Refraction 141
    • 3.5.2.10 Axial Length 141
    • 3.5.2.11 Cataract Type 144 Discussion 151
    • 4.5.2.11.3 Total Component of the High HOA 177
    • 4.5.2.11.4 Total Component of the T.Coma HOA 178
    • 4.5.2.11.5 Total Component of the T.Trefoil HOA 179
    • 4.5.2.11.6 Total Component of the T.4Foil HOA 179
    • 4.5.2.11.7 Total Component of the T.Sph HOA 181
    • 4.5.2.11.8 The Total Component of the HiAstig 181 Explanatory Analysis of Associations between the 182 Demographic, Structural and Functional Variables and each of the Three Components of each of the Eight HOAs Obtained at the First Follow-up Examination 4.5.3.1 Age 183 4.5.3.2 Distance Visual Acuity 183 4.5.3.3 Near Visual Acuity 184 4.5.3.4 Contrast Sensitivity 184 4.5.3.5 Dilated Pupil Diameter 184 4.5.3.6 Mean Corneal Curvature 186 4.5.3.7 Flattest Corneal Curvature 187 4.5.3.8 Corneal Endothelial Cell Density 188 4.5.3.9 Spherical Equivalent Refraction 191 Characteristics of the Case Series for the Investigation of the 191 Change in the HOAs from the Pre-operative to the First Follow-up Examinations 4.5.4.1 Spherical Equivalent Refraction 191 4.5.4.2 Distance Visual Acuity 192 4.5.4.3 Near Visual Acuity 193 4.5.4.4 Contrast Sensitivity 195 4.5.4.5 Dilated Pupil Diameter 198 4.5.4.6 Mean Corneal Curvature 199 4.5.4.7 Flattest Corneal Curvature 201 4.5.4.8 Corneal Endothelial Cell Density 203 4.5.4.9 Higher Order Aberrations 204
    • 4.5.4.9.1 Total Component of the Total HOA 204
    • 4.5.4.9.2 Total Component of the Tilt (S1) HOA 204
    • 4.5.4.9.3 Total Component of the High HOA 206
    • 4.5.4.9.4 Total Component of the T.Coma HOA 208
    • 4.5.4.9.5 Total Component of the T.Trefoil HOA 208
    • 4.5.4.9.6 Total Component of the T.4Foil HOA 209
    • 4.5.4.9.7 Total Component of the T.Sph HOA 210
    • 4.5.4.9.8 Total Component of the HiAstig HOA 212 Explanatory Analysis of Associations between the 214 Confounding Variables, the Change in the Appropriate Demographic, Structural and Functional Variables from the Pre-operative to the First Follow-up Examination and the Corresponding Change in each of the Three Components of each of the Eight HOAs 4.5.5.1 Age and Gender 214 4.5.5.2 Surgeon 214 4.5.5.3 Type of Intra Ocular Lens 216 4.5.5.4 Interval from the Pre-operative Examination 217
    • to the First Follow-up Examination 4.5.5.5 Interval from the Pre-operative Examination 217
    • to Surgery 4.5.5.6 Distance Visual Acuity 220 4.5.5.7 Near Visual Acuity 220 4.5.5.8 Contrast Sensitivity 220 5.5.2.6 Contrast Sensitivity 257 5.5.2.7 Dilated Pupil Diameter 259 5.5.2.8 Mean Corneal Curvature 259 5.5.2.9 Flattest Corneal Curvature 260 5.5.2.10 Corneal Endothelial Cell Density 261 5.5.2.11 Higher Order Aberrations 261
    • 5.5.2.11.1 Total Component of the Total HOA 262
    • 5.5.2.11.2 Total Component of the Tilt (S1) HOA 263
    • 5.5.2.11.3 Total Component of the High HOA 263
    • 5.5.2.11.4 Total Component of the T.Coma HOA 264
    • 5.5.2.11.5 Total Component of the T.Trefoil HOA 264
    • 5.5.2.11.6 Total Component of the T.4Foil HOA 265
    • 5.5.2.11.7 Total Component of the T.Sph HOA 265
    • 5.5.2.11.8 Total Component of the HiAstig HOA 267 Explanatory Analysis of Associations between the 268 Demographic, Structural and Functional Variables and each of the Three Components of each of the Eight HOAs Obtained at the Second Follow-up Examination 5.5.3.1 Age 268 5.5.3.2 Distance Visual Acuity 270 5.5.3.3 Near Visual Acuity 271 5.5.3.4 Contrast Sensitivity 272 5.5.3.5 Dilated Pupil Diameter 273 5.5.3.6 Mean Corneal Curvature 273 5.5.3.7 Flattest Corneal Curvature 274 5.5.3.8 Corneal Endothelial Cell Density 274 5.5.3.9 Spherical Equivalent Refraction 275
    • 6.4.1.2.3 Spherical Equivalent Refraction
    • 6.4.1.2.4 Distance Visual Acuity
    • 6.4.1.2.5 Near Visual Acuity
    • 6.4.1.2.6 Mean Corneal Curvature
    • 6.4.1.2.7 Flattest Corneal Curvature 6.4.1.3 Clear Media Case Series
    • 6.4.1.3.1 Age and Gender
    • 6.4.1.3.2 Spherical Equivalent Refraction
    • 6.4.1.3.3 Distance Visual Acuity
    • 6.4.1.3.4 Near Visual Acuity
    • 6.4.1.3.5 Mean Corneal Curvature
    • 6.4.1.3.6 Flattest Corneal Curvature Higher Order Aberrations Comparison of the HOAs between Case Series 6.4.3.1 Pre- and Post-operative Case Series 6.4.3.2 Pre-operative and 'Less Severe' Cataract
    • Case Series 6.4.3.3 Post-operative and Clear Media Case Series 6.4.3.4 Post-operative and 'Less Severe' Cataract
    • Case Series 6.4.3.5 Pre-operative and Clear Media Case Series 6.4.3.6 'Less Severe' Cataract and Clear Media
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