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Goggs, R A; Chan, D L; Benigni, L; Hirst, C; Kellet-Gregory, L M; Fuentes, V L
Publisher: John Wiley & Sons, Ltd
Journal: The Journal of Small Animal Practice
Languages: English
Types: Article
Subjects: Petsavers Papers
Objectives To evaluate the feasibility of CT pulmonary angiography for identification of naturally occurring pulmonary thromboembolism in dogs using predefined diagnostic criteria and to assess the ability of echocardiography, cardiac troponins, D-dimers and kaolin-activated thromboelastography to predict the presence of pulmonary thromboembolism in dogs. Methods Twelve dogs with immune-mediated haemolytic anaemia and evidence of respiratory distress were prospectively evaluated. Dogs were sedated immediately before CT pulmonary angiography using intravenous butorphanol. Spiral CT pulmonary angiography was performed with a 16 detector-row CT scanner using a pressure injector to infuse contrast media through peripheral intravenous catheters. Pulmonary thromboembolism was diagnosed using predefined criteria. Contemporaneous tests included echocardiography, arterial blood gas analysis, kaolin-activated thromboelastography, D-dimers and cardiac troponins. Results Based on predefined criteria, four dogs were classified as pulmonary thromboembolism positive, three dogs were suspected to have pulmonary thromboembolism and the remaining five dogs had negative scans. The four dogs identified with pulmonary thromboembolism all had discrete filling defects in main or lobar pulmonary arteries. None of the contemporaneous tests was discriminant for pulmonary thromboembolism diagnosis, although the small sample size was limiting. Clinical Significance CT pulmonary angiography can be successfully performed in dogs under sedation, even in at-risk patients with respiratory distress and can both confirm and rule out pulmonary thromboembolism in dogs.
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    • Baumwart, R. D., Meurs, K. M. & Bonagura, J. D. (2005) Tei index of myocardial performance applied to the right ventricle in normal dogs. Journal of Veterinary Internal Medicine 19, 828-832
    • Becattini, C., Vedovati, M. C. & Agnelli, G. (2007) Prognostic value of troponins in acute pulmonary embolism - a meta-analysis. Circulation 116, 427-433
    • Ben, S. Q., Ni, S. S., Shen, H. H., et al. (2007) The dynamic changes of LDH isoenzyme 3 and D-dimer following pulmonary thromboembolism in canine. Thrombosis Research 120, 575-583
    • Büller, H.R., Prins, M.H., Lensin, A.W., et al. (2012) Oral rivaroxaban for the treatment of symptomatic pulmonary embolism. New England Journal of Medicine 366, 1287-1297
    • Bunch, S. E., Metcalf, M. R., Crane, S. W., et al. (1989) Idiopathic pleural effusion and pulmonary thromboembolism in a dog with autoimmune hemolytic anemia. Journal of the American Veterinary Medical Association 195, 1748-1753
    • Carr, A. P., Panciera, D. L. & Kidd, L. (2002) Prognostic factors for mortality and thromboembolism in canine immune-mediated hemolytic anemia: a retrospective study of 72 dogs. Journal of Veterinary Internal Medicine 16, 504-509
    • Cassel, N., Carstens, A. & Becker, P. (2013) The comparison of bolus tracking and test bolus techniques for computed tomography thoracic angiography in healthy beagles. Journal of the South African Veterinary Association 84, E1-E9
    • Cronin, P., Weg, J. G. & Kazerooni, E. A. (2008) The role of multidetector computed tomography angiography for the diagnosis of pulmonary embolism. Seminars in Nuclear Medicine 38, 418-431
    • Dewhurst, E., Cue, S., Crawford, E., et al. (2008) A retrospective study of canine D-dimer concentrations measured using an immunometric “Point-of-Care” test. Journal of Small Animal Practice 49, 344-348
    • Drees, R., Frydrychowicz, A., Keuler, N. S., et al. (2011) Pulmonary angiography with 64-multidetector-row computed tomography in normal dogs. Veterinary Radiology & Ultrasound 52, 362-367
    • Fenty, R. K., Delaforcade, A. M., Shaw, S. E., et al. (2011) Identification of hypercoagulability in dogs with primary immune-mediated hemolytic anemia by means of thromboelastography. Journal of the American Veterinary Medical Association 238, 463-467
    • Ferrari, E., Moceri, P., Crouzet, C., et al. (2012) Timing of troponin I measurement in pulmonary embolism. Heart 98, 732-735
    • Fesmire, F. M., Brown, M. D., Espinosa, J. A., et al. (2011) Critical issues in the evaluation and management of adult patients presenting to the emergency department with suspected pulmonary embolism. Annals of Emergency Medicine 57, 628-652 e675
    • Ghaye, B. (2007) Peripheral pulmonary embolism on multidetector CT pulmonary angiography. Belgian Journal of Radiology 90, 100-108
    • Goggs, R., Benigni, L., Fuentes, V. L., et al. (2009) Pulmonary thromboembolism. Journal of Veterinary Emergency and Critical Care 19, 30-52
    • Goggs, R., Wiinberg, B., Kjelgaard-Hansen, M., et al. (2012) Serial assessment of the coagulation status of dogs with immune-mediated haemolytic anaemia using thromboelastography. Veterinary Journal 191, 347-353
    • Goodman, L. R., Curtin, J. J., Mewissen, M. W., et al. (1995) Detection of pulmonary-embolism in patients with unresolved clinical and scintigraphic diagnosis - helical CT versus angiography. American Journal of Roentgenology 164, 1369-1374
    • Habing, A., Coelho, J. C., Nelson, N., et al. (2011) Pulmonary angiography using 16 slice multidetector computed tomography in normal dogs. Veterinary Radiology & Ultrasound 52, 173-178
    • Hall, K. & Lee, J. A. (2009) Nonrespiratory look-alikes. In: Small Animal Critical Care Medicine. 1st edn. Eds D. C. Silverstein and K. Hopper. Saunders, St. Louis, MO, USA. pp 141-144
    • Huisman, M. V. & Klok, F. A. (2013) Diagnostic management of acute deep vein thrombosis and pulmonary embolism. Journal of Thrombosis and Haemostasis 11, 412-422
    • Janata, K., Holzer, M., Laggner, A. N., et al. (2003) Cardiac troponin T in the severity assessment of patients with pulmonary embolism: cohort study. British Medical Journal 326, 312-313
    • Johnson, L. R., Lappin, M. R. & Baker, D. C. (1999) Pulmonary thromboembolism in 29 dogs: 1985-1995. Journal of Veterinary Internal Medicine 13, 338-345
    • Jones, S. E. & Wittram, C. (2005) The indeterminate CT pulmonary angiogram: imaging characteristics and patient clinical outcome. Radiology 237, 329-337
    • Jung, J., Chang, J., Oh, S., et al. (2010) Computed tomography angiography for evaluation of pulmonary embolism in an experimental model and heartworm infested dogs. Veterinary Radiology & Ultrasound 2010 51, 288-293
    • Jung, J. I., Kim, K. J., Ahn, M. I., et al. (2011) Detection of pulmonary embolism using 64-slice multidetector-row computed tomography: accuracy and reproducibility on different image reconstruction parameters. Acta Radiologica 52, 417-421
    • Kidd, L. & Mackman, N. (2013) Prothrombotic mechanisms and anticoagulant therapy in dogs with immune-mediated hemolytic anemia. Journal of Veterinary Emergency and Critical Care 23, 3-13
    • Kirberger, R. M. & Zambelli, A. (2007) Imaging diagnosis - aortic thromboembolism associated with spirocercosis in a dog. Veterinary Radiology & Ultrasound 48, 418-420
    • Klein, M. K., Dow, S. W. & Rosychuk, R. A. (1989) Pulmonary thromboembolism associated with immune-mediated hemolytic anemia in dogs: ten cases (1982- 1987). Journal of the American Veterinary Medical Association 195, 246-250
    • McConnell, M. V., Solomon, S. D., Rayan, M. E., et al. (1996) Regional right ventricular dysfunction detected by echocadiography in acute pulmonary embolism. American Journal of Cardiology 78, 469-473
    • McIntyre, K. M. & Sasahara, A. A. (1971) Hemodynamic response to pulmonary embolism in patients without prior cardiopulmonary disease. American Journal of Cardiology 28, 288-294
    • Pariaut, R., Saelinger, C., Strickland, K. N., et al. (2012) Tricuspid annular plane systolic excursion (TAPSE) in dogs: reference values and impact of pulmonary hypertension. Journal of Veterinary Internal Medicine 26, 1148-1154
    • Park, J. -H., Park, Y. S., Park, S. J., et al. (2008) Midventricular peak systolic strain and Tei index of the right ventricle correlated with decreased right ventricular systolic function in patients with acute pulmonary thromboembolism. International Journal of Cardiology 125, 319-324
    • Park, J. -H., Kim, J. H., Lee, J. -H., et al. (2012) Evaluation of right ventricular systolic function by the analysis of tricuspid annular motion in patients with acute pulmonary embolism. Journal of Cardiovascular Ultrasound 20, 181-188
    • Piek, C. J., Brinkhof, B., Teske, E., et al. (2011) High intravascular tissue factor expression in dogs with idiopathic immune-mediated haemolytic anaemia. Veterinary Immunology and Immunopathology 144, 346-354
    • Prosek, R. & Ettinger, S. J. (2010) Biomarkers of cardiovascular disease. In: Textbook of Veterinary Internal Medicine. 7th edn. Eds S. J. Ettinger and E. C. Feldman. Saunders Elsevier, St. Louis, MO, USA. pp 1187-1195
    • Reimer, M. E., Troy, G. C. & Warnick, L. D. (1999) Immune-mediated hemolytic anemia: 70 cases (1988-1996). Journal of the American Animal Hospital Association 35, 384-391
    • Rydman, R., Soderberg, M., Larsen, F., et al. (2010) Echocardiographic evaluation of right ventricular function in patients with acute pulmonary embolism: a study using tricuspid annular motion. Echocardiography 27, 286-293
    • Scott-Moncrieff, J. C., Treadwell, N. G., McCullough, S. M., et al. (2001) Hemostatic abnormalities in dogs with primary immune-mediated hemolytic anemia. Journal of the American Animal Hospital Association 37, 220-227
    • Sharifi, M., Bay, C., Skrocki, L., et al. (2013) Moderate pulmonary embolism treated with thrombolysis (from the “MOPETT” Trial). American Journal of Cardiology 111, 273-277
    • Sinnott, V. B. & Otto, C. M. (2009) Use of thromboelastography in dogs with immune-mediated hemolytic anemia: 39 cases (2000-2008). Journal of Veterinary Emergency and Critical Care 19, 484-488
    • Spratt, D. P., Mellanby, R. J., Drury, N., et al. (2005) Cardiac troponin I: evaluation I of a biomarker for the diagnosis of heart disease in the dog. Journal of Small Animal Practice 46, 139-145
    • Suter, P. F. (1984) Lower airway and pulmonary parenchymal diseases. In: Thoracic Radiography: A Text Atlas of Thoracic Diseases of the Dog and Cat. Ed P. F. Suter. Wettswil, Basel, Switzerland. pp 517-682
    • Takahashi, A., Yamada, K., Kishimoto, M., et al. (2008) Computed tomography (CT) observation of pulmonary emboli caused by long-term administration of ivermectin in dogs experimentally infected with heartworms. Veterinary Parasitology 155, 242-248
    • Teshima, K., Asano, K., Iwanaga, K., et al. (2006) Evaluation of right ventricular Tei index (index of myocardial performance) in healthy dogs and dogs with tricuspid regurgitation. Journal of Veterinary Medical Science 68, 1307-1313
    • Tidwell, S.A., Graham, J.P., Peck, J.N., Berry, C.R. (2007) Incidence of pulmonary embolism after non-cemented total hip arthroplasty in eleven dogs: computed tomographic pulmonary angiography and pulmonary perfusion scintigraphy. Veterinary Surgery 36, 37-42
    • Torbicki, A., Perrier, A., Konstantinides, S., et al. (2008) Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). European Heart Journal 29, 2276-2315
    • Venco, L., Calzolari, D. & Morini, S. (1998) Pulmonary thromboembolism in a dog with renal amyloidosis. Veterinary Radiology & Ultrasound 39, 564-565
    • Weiss, D. J. & Brazzell, J. L. (2006) Detection of activated platelets in dogs with primary immune-mediated hemolytic anemia. Journal of Veterinary Internal Medicine 20, 682-686
    • Wells, P. S., Anderson, D. R., Rodger, M., et al. (2000) Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: Increasing the models utility with the SimpliRED D-dimer. Thrombosis and Haemostasis 83, 416-420
    • Wiinberg, B., Jensen, A. L., Rojkjaer, R., et al. (2005) Validation of human recombinant tissue factor-activated thromboelastography on citrated whole blood from clinically healthy dogs. Veterinary Clinical Pathology 34, 389-393
    • Wittram, C., Maher, M. M., Yoo, A. J., et al. (2004) CT angiography of pulmonary embolism: diagnostic criteria and causes of misdiagnosis. Radiographics 24, 1219-1238
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